A hierarchically designed nanocomposite hydrogel with multisensory capabilities towards wearable devices for human-body motion and glucose concentration detection

Garg, Vivek; Gupta, Tanmay; Rani, Seema; Bandyopadhyay‐Ghosh, Sanchita; Ghosh, Subrata Bandhu; Qiao, Laicong; Liu, Guozhen

doi:10.1016/j.compscitech.2021.108894

Cited by 43 publications

(32 citation statements)

References 64 publications

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“…The thermally exfoliated graphene oxide (TEGO) helps in the formation of additional crosslink, thereby increasing electrochemical property. The sensor exhibits glucose detection range of 0.2 μM–10 mM with limit of detection of 0.2 μM [ 190 ]. Furthermore, it was well noted that graphene doped with gold and combined with a gold mesh has improved electrochemical activity over bare graphene which was sufficient to form a wearable patch for sweat-based diabetes.…”

Section: Classification Of Graphene-based Wearable Biosensorsmentioning

confidence: 99%

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

et al. 2022

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Given the huge economic burden caused by chronic and acute diseases on human beings, it is an urgent requirement of a cost-effective diagnosis and monitoring process to treat and cure the disease in their preliminary stage to avoid severe complications. Wearable biosensors have been developed by using numerous materials for non-invasive, wireless, and consistent human health monitoring. Graphene, a 2D nanomaterial, has received considerable attention for the development of wearable biosensors due to its outstanding physical, chemical, and structural properties. Moreover, the extremely flexible, foldable, and biocompatible nature of graphene provide a wide scope for developing wearable biosensor devices. Therefore, graphene and its derivatives could be trending materials to fabricate wearable biosensor devices for remote human health management in the near future. Various biofluids and exhaled breath contain many relevant biomarkers which can be exploited by wearable biosensors non-invasively to identify diseases. In this article, we have discussed various methodologies and strategies for synthesizing and pattering graphene. Furthermore, general sensing mechanism of biosensors, and graphene-based biosensing devices for tear, sweat, interstitial fluid (ISF), saliva, and exhaled breath have also been explored and discussed thoroughly. Finally, current challenges and future prospective of graphene-based wearable biosensors have been evaluated with conclusion. Graphical abstract Graphene is a promising 2D material for the development of wearable sensors. Various biofluids (sweat, tears, saliva and ISF) and exhaled breath contains many relevant biomarkers which facilitate in identify diseases. Biosensor is made up of biological recognition element such as enzyme, antibody, nucleic acid, hormone, organelle, or complete cell and physical (transducer, amplifier), provide fast response without causing organ harm.

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Section: Classification Of Graphene-based Wearable Biosensorsmentioning

confidence: 99%

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

et al. 2022

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“…[19,[32][33][34] Hydrogen bonds and boric acid ester bonds are reversible bonds that have been widely studied and successfully proposed for a wide range application of selfhealing systems. [35][36][37] In addition, polyvinyl alcohol (PVA) with non-toxic, harmless, inexpensive, and good biocompatibility, is a common polymer material [38][39][40][41] and attracts a myriad of research interest in recent years. [42][43][44][45] For example, starch-based composite gel with automatic and rapid self-healing and reusability was prepared by building new PVA network.…”

Section: Introductionmentioning

confidence: 99%

A Chewing Gum Residue‐Based Gel with Superior Mechanical Properties and Self‐Healability for Flexible Wearable Sensor

Zhao

Zeng

et al. 2022

Macromol. Rapid Commun.

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Chewing gum residue is hard to decompose and easy to cause pollution, which is highly desirable to realize recycling. In this paper, a chewing gum gel with enhanced mechanical properties and self‐healing properties is prepared by using polyvinyl alcohol (PVA) as the backbone in chewing gum residue. The hydrogen bond and the borax ester bond are employed to construct reversible interaction to enhance the self‐healing ability. The physical crosslinking is realized by further freeze‐thaw treatment to improve its mechanical properties. The gel demonstrates high elongation at break of 610% and strength of 0.11 MPa, as well as excellent self‐healing performance and recyclable properties. In particular, the gel with a fast signal response is successfully applied as a wearable strain sensor to monitor different types of human motion. The gel as a sensor exhibits self‐healing properties suggesting superior safety and stability, and displays wide linear sensitivity (the gauge factor is 0.417 and 0.170). The gel can be further served to explore temperature changes, implying the application in temperature monitoring. This study develops a novel approach for the recycle and reuse of chewing gum residue. The obtained gel may be a promising candidate for the fabrication of flexible wearable sensor.

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“…The current COVID-19 pandemic facilitates the market demand for tools for disease diagnosis, prevention and management. It also boosts the development of wearable sensing technology which is evidenced as an exciting and emerging field of the research field and is matching proudly forward from monitoring of physical exercise activity to health conditions (Kim et al, 2019;Garg, et al, 2021). Due to its non-invasive and point-of-care nature, wearables win their wide applications in healthcare service.…”

Section: Introductionmentioning

confidence: 99%

Advances in Biosensors for Continuous Glucose Monitoring Towards Wearables

Johnston

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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104

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Continuous glucose monitors (CGMs) for the non-invasive monitoring of diabetes are constantly being developed and improved. Although there are multiple biosensing platforms for monitoring glucose available on the market, there is still a strong need to enhance their precision, repeatability, wearability, and accessibility to end-users. Biosensing technologies are being increasingly explored that use different bodily fluids such as sweat and tear fluid, etc., that can be calibrated to and therefore used to measure blood glucose concentrations accurately. To improve the wearability of these devices, exploring different fluids as testing mediums is essential and opens the door to various implants and wearables that in turn have the potential to be less inhibiting to the wearer. Recent developments have surfaced in the form of contact lenses or mouthguards for instance. Challenges still present themselves in the form of sensitivity, especially at very high or low glucose concentrations, which is critical for a diabetic person to monitor. This review summarises advances in wearable glucose biosensors over the past 5 years, comparing the different types as well as the fluid they use to detect glucose, including the CGMs currently available on the market. Perspectives on the development of wearables for glucose biosensing are discussed.

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A hierarchically designed nanocomposite hydrogel with multisensory capabilities towards wearable devices for human-body motion and glucose concentration detection

Cited by 43 publications

References 64 publications

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

Advanced wearable biosensors for the detection of body fluids and exhaled breath by graphene

A Chewing Gum Residue‐Based Gel with Superior Mechanical Properties and Self‐Healability for Flexible Wearable Sensor

Advances in Biosensors for Continuous Glucose Monitoring Towards Wearables

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