A Hierarchy of Cell Intrinsic and Target-Derived Homeostatic Signaling

Abstract

Homeostatic control of neural function can be mediated by the regulation of ion channel expression, neurotransmitter receptor abundance, or modulation of presynaptic release. These processes can be implemented through cell autonomous or intercellular signaling. It remains unknown whether different forms of homeostatic regulation can be coordinated to achieve constant neural function. One way to approach this question is to confront a simple neural system with conflicting perturbations and determine whether the outcome reflects a coordinated, homeostatic response. Here we demonstrate that two A-type potassium channel genes, shal and shaker, are reciprocally, transcriptionally coupled to maintain A-type channel expression. We then demonstrate that this homeostatic control of A-type channel expression prevents target-dependent, homeostatic modulation of synaptic transmission. Thus, we uncover a novel homeostatic mechanism that reciprocally regulates A-type potassium channels and we define a hierarchical relationship between cell-intrinsic control of ion channel expression and target-derived homeostatic control of synaptic transmission.

Rapid Active Zone Remodeling during Synaptic Plasticity

“…Synaptic homeostasis at the Drosophila NMJ has become an extensively studied model system to analyze the molecular mechanisms of synaptic plasticity (Petersen et al, 1997;DiAntonio et al, 1999;Goda and Davis, 2003;Frank et al, 2006;Goold and Davis, 2007;Dickman and Davis, 2009;Frank et al, 2009;Bergquist et al, 2010). In this study, we aimed at resolving changes in p vr and N during synaptic plasticity at the Drosophila NMJ.…”

Fuzzy Logic and S‐Lagrangian Dynamics of Living Systems: Theory of Homeostasis

“…In theoretical research, the problem is often evaluated by the introduction of positive-and negative-feedback loops between the sensor and the metabolic flaw (e.g., [6,7]). Attempts to model homeostatic regulation consider only simple homeostasis, with regulation of each variable described by the introduction of specific individual controllers.…”

“…Note that S-Lagrangian is not an invariant under the addition of a function which is a total derivative with respect to time. 6 It should be emphasized that the derivation of these equations in Ref. [17] does not depend on any specific properties of the system or its Lagrangian.…”

“…5 In the classical mechanics, S-variable is nothing more than common mechanical action. 6 In the classical mechanics, S-variable is nothing more than common mechanical action.…”

Roles of somatic A-type K+ channels in the synaptic plasticity of hippocampal neurons

“…Genetic identification in Drosophila has revealed that several channel proteins encoded by the Shal family of K + channels (Kv4 channels) underlie the major I A in the somatodendritic compartment of neurons and show a more hyperpolarized voltage-dependence of gating properties [11,12] , while Shaker channels (Kv1) are localized exclusively to muscle cells [13] . For a decade, the Kv subunits contributing to I A in neurons have been the focus to explain the functions that modulate dendritic signal processing, AP propagation, synaptic integration, and the filtering of fast synaptic potentials [14][15][16][17][18][19] .…”