A hierarchy of event-related potential markers of auditory processing in disorders of consciousness

Beukema, Steve; González-Lara, Laura E.; Finoia, Paola; Kamau, Evelyn; Allanson, Judith; Chennu, Srivas; Gibson, Raechelle M.; Pickard, John D.; Owen, Adrian M.; Cruse, D. Alan

doi:10.1016/j.nicl.2016.08.003

Cited by 56 publications

(53 citation statements)

References 52 publications

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“…Applying this model to speech comprehension, Rohaut et al (2015) proposed a two-stage ERP profile, with an initial unconscious semantic prediction error in response to each word (the N400, typically onsetting around 200ms post-stimulus) and a late positive complex (LPC; in this case onsetting around 600ms post-stimulus) reflecting the ignition of meaning into conscious access. In support of this proposal, the N400 ERP has been observed in states of relative unawareness such as sleep, coma, and vegetative state (or unresponsive wakefulness syndrome) (Beukema et al, 2016;Ibáñez et al, 2006;Kotchoubey et al, 2005;Rämä et al, 2010) while the LPC has only been reported in conscious individuals, or in those who were conscious of and subsequently could report target words (Rohaut et al, 2015;Sergent et al, 2005;van Gaal et al, 2014).…”

Section: Introductionmentioning

confidence: 86%

Event-related potentials reflect prediction errors and pop-out during comprehension of degraded speech

Banellis

Sokoliuk

Wild

et al. 2020

Preprint

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Comprehension of degraded speech requires higher-order expectations informed by prior-knowledge. Accurate top-down expectations of incoming degraded speech cause a subjective semantic "pop-out" or conscious breakthrough experience. Indeed, the same stimulus can be perceived as meaningless when no expectations are made in advance. We investigated the ERP correlates of these top-down expectations, their error signals, and the subjective pop-out experience in healthy participants. We manipulated expectations in a word-pair priming noise-vocoded speech task and investigated the role of top-down expectation with a between-groups attention manipulation. Consistent with the role of expectations in comprehension, repetition priming significantly enhanced perceptual intelligibility of the noise-vocoded degraded targets for attentive participants. An early ERP was larger for mismatched (i.e. unexpected) targets than matched targets, indicative of an initial error signal not reliant on top-down expectations. Subsequently, a P3a-like ERP was larger to matched targets than mismatched targets only for attending participants -i.e. a pop-out effect. Rather than relying on complex post hoc interactions between prediction error and precision to explain this apredictive pattern, we consider our data to be consistent with prediction error minimisation accounts for early stages of processing followed by Global Neuronal Workspace-like breakthrough and processing in service of task goals.

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Section: Introductionmentioning

confidence: 86%

Event-related potentials reflect prediction errors and pop-out during comprehension of degraded speech

Banellis

Sokoliuk

Wild

et al. 2020

Preprint

Self Cite

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“…Attempts to discriminate auditory attention and processing in these MCS patients with electroencephalography (EEG) have focused on event‐related potential paradigms utilizing single words and repeated sound sequences 9, 10, 11, 12, 13. While such EEG measures appear to index cognitive processes, it is not clear that ERPs capture the type of auditory attention required to comprehend speech in everyday environments.…”

Section: Introductionmentioning

confidence: 99%

Divergent neural responses to narrative speech in disorders of consciousness

Iotzov

Fidali

Petroni

et al. 2017

Ann Clin Transl Neurol

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ObjectiveClinical assessment of auditory attention in patients with disorders of consciousness is often limited by motor impairment. Here, we employ intersubject correlations among electroencephalography responses to naturalistic speech in order to assay auditory attention among patients and healthy controls.MethodsElectroencephalographic data were recorded from 20 subjects with disorders of consciousness and 14 healthy controls during of two narrative audio stimuli, presented both forwards and time‐reversed. Intersubject correlation of evoked electroencephalography signals were calculated, comparing responses of both groups to those of the healthy control subjects. This analysis was performed blinded and subsequently compared to the diagnostic status of each patient based on the Coma Recovery Scale‐Revised.ResultsSubjects with disorders of consciousness exhibit significantly lower intersubject correlation than healthy controls during narrative speech. Additionally, while healthy subjects had higher intersubject correlation values in forwards versus backwards presentation, neural responses did not vary significantly with the direction of playback in subjects with disorders of consciousness. Increased intersubject correlation values in the backward speech condition were noted with improving disorder of consciousness diagnosis, both in cross‐sectional analysis and in a subset of patients with longitudinal data.InterpretationIntersubject correlation of neural responses to narrative speech audition differentiates healthy controls from patients and appears to index clinical diagnoses in disorders of consciousness.

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“…As we hypothesise that the neural representations of motor and non-motor verbs are not entirely overlapping, we also tested for differences in the scalp topographies across conditions with a randomisation test of global dissimilarity (see 51 ). For each time-window of interest, we calculated the global dissimilarity (i.e.…”

Section: Sensor Analyses: Erpsmentioning

confidence: 99%

Dissociable electrophysiological correlates of semantic access of motor and non-motor concepts

Sokoliuk

Calzolari

Cruse

2019

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The notion of semantic embodiment posits that concepts are represented in the same neural sensorimotor systems that were involved in their acquisition. However, evidence in support of embodied semantics -in particular the hypothesised contribution of motor and premotor cortex to the representation of action concepts -is varied. Here, we tested the hypothesis that, consistent with semantic embodiment, sensorimotor cortices will rapidly become active while healthy participants access the meaning of visually-presented motor and non-motor action verbs. Event-related potentials revealed early differential processing of motor and nonmotor verbs (164-203ms) within distinct regions of cortex likely reflecting rapid cortical activation of differentially distributed semantic representations. However, we found no evidence for a specific role of sensorimotor cortices in supporting these representations. Moreover, we observed a later modulation of the alpha band (8-12Hz) from 555-785ms over central electrodes, with estimated generators within the left superior parietal lobule, which may reflect post-lexical activation of the object-directed features of the motor action concepts. In conclusion, we find no evidence for a specific role of sensorimotor cortices when healthy participants judge the meaning of visually-presented action verbs. However, the relative contribution of sensorimotor cortices to action comprehension may vary as a function of task goals.

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A hierarchy of event-related potential markers of auditory processing in disorders of consciousness

Cited by 56 publications

References 52 publications

Event-related potentials reflect prediction errors and pop-out during comprehension of degraded speech

Event-related potentials reflect prediction errors and pop-out during comprehension of degraded speech

Divergent neural responses to narrative speech in disorders of consciousness

Dissociable electrophysiological correlates of semantic access of motor and non-motor concepts

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