2019
DOI: 10.1002/cti2.1043
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A high burden of cytomegalovirus marks poor vascular health in transplant recipients more clearly than in the general population

Abstract: ObjectivesMeta‐analyses have now confirmed that persistent infections with cytomegalovirus (CMV) can accelerate the onset of diseases of ageing, notably cardiovascular pathologies. We address the circumstances in which the association may be strong enough to warrant intervention to reduce the viral burden.ResultsWe compare markers of the burden of CMV with established indices of vascular pathology in healthy adults (n = 82) and in renal transplant recipients (RTR; n = 81). Levels of all inflammatory and vascul… Show more

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Cited by 16 publications
(17 citation statements)
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“…HCMV has long been associated with cardiovascular complications (17). HCMVassociated cardiovascular dysfunction includes increased morbidity during atherosclerosis, myocarditis, and transplant vasculopathy (20,32,34,41). Myocarditis is defined as inflammation of the heart muscle caused by infiltrating immune cells, which results in dysfunction of the heart.…”
Section: Introductionmentioning
confidence: 99%
“…HCMV has long been associated with cardiovascular complications (17). HCMVassociated cardiovascular dysfunction includes increased morbidity during atherosclerosis, myocarditis, and transplant vasculopathy (20,32,34,41). Myocarditis is defined as inflammation of the heart muscle caused by infiltrating immune cells, which results in dysfunction of the heart.…”
Section: Introductionmentioning
confidence: 99%
“…In this cohort, levels of CMV antibody were an independent marker of reduced FMD [27] and CMV DNA in both saliva and plasma aligned weakly with impaired FMD. FMD is an assessment of endothelial function based on the ability of the artery to respond to shear stress [28].…”
Section: Discussionmentioning
confidence: 99%
“…As described previously, 14 RTR ( n = 81) were recruited from the renal clinics at Royal Perth Hospital, Western Australia in 2014. This is defined as the baseline.…”
Section: Methodsmentioning
confidence: 99%
“…Coefficients of variance were 6.1% (CMV lysate), 2.9% (gB), and 4.8% (IE‐1). Results are presented as arbitrary units (AU)/mL based on a standard plasma pool 14 . This strategy permits comparisons between volunteers but not between antigens.…”
Section: Methodsmentioning
confidence: 99%