“…HSP60, an important mitochondrial stress protein, has been shown to play key roles in the protein synthesis, folding, and delivery of misfolded proteins to proteolytic enzymes in the mitochondrial matrix (Tatsuta 2009, Haynes & Ron 2010, Hu & Liu 2011, Marino Gammazza et al 2018. Recent studies have showed that mitochondrial stress is associated with mitochondrial dysfunction and metabolic disorders such as hepatic steatosis, insulin resistance, and type 2 diabetes (Venojarvi et al 2008, Hu & Liu 2011, Comert et al 2019, Einer et al 2019. ER and mitochondria have partially overlapping functions, and there is strong crosstalk between the two organelles to regulate hepatic steatosis (Haynes & Ron 2010, Hu & Liu 2011, Ghemrawi et al 2018.…”