2016
DOI: 10.1016/j.biomaterials.2016.06.002
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A high capacity polymeric micelle of paclitaxel: Implication of high dose drug therapy to safety and in vivo anti-cancer activity

Abstract: The poor solubility of paclitaxel (PTX), the commercially most successful anticancer drug, has long been hampering the development of suitable formulations. Here, we present translational evaluation of a nanoformulation of PTX, which is characterized by a facile preparation, extraordinary high drug loading of 50 % wt. and PTX solubility of up to 45 g/L, excellent shelf stability and controllable, sub-100 nm size. We observe favorable in vitro and in vivo safety profiles and a higher maximum tolerated dose comp… Show more

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Cited by 171 publications
(196 citation statements)
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“…30 Such low drug loadings are very unfavorable for drug delivery of chemotherapeutic agents to treat cancer. 9 In the present study, however, the highly loaded ETO-containing POx micelles displayed elongated morphology, which was sustained for the ETO/C 6 CP PM even though the single drug micelles of C 6 CP were spherical. It is amazing that the elongated morphology was observed at drug loadings as high as ~43% for single drug ETO PM and ~52% for co-loaded C 6 CP/ETO PM.…”
Section: Discussioncontrasting
confidence: 48%
See 1 more Smart Citation
“…30 Such low drug loadings are very unfavorable for drug delivery of chemotherapeutic agents to treat cancer. 9 In the present study, however, the highly loaded ETO-containing POx micelles displayed elongated morphology, which was sustained for the ETO/C 6 CP PM even though the single drug micelles of C 6 CP were spherical. It is amazing that the elongated morphology was observed at drug loadings as high as ~43% for single drug ETO PM and ~52% for co-loaded C 6 CP/ETO PM.…”
Section: Discussioncontrasting
confidence: 48%
“…8,9 ETO was purchased from LC Laboratories (Woburn, MA). Cisplatin was purchased from Sigma, and Toposar was purchased from UNC Hospital Pharmacy.…”
Section: Methodsmentioning
confidence: 99%
“…44,45 OA has also drawn extensive attention owing to its biological Abbreviations: Nsclc, non-small-cell lung cancer; Oa, oleanolic acid. β β β activity in cancer therapy.…”
Section: Discussionmentioning
confidence: 99%
“…30 However, the major problem for the clinical efficacy of PTX is compromised by its poor water solubility, low permeability, and serious adverse effects. 31 Therefore, to improve the anticancer efficacy, Ag@PEI@PTX was synthesized by PEI-conjugated AgNPs to induce cancer cell apoptosis.…”
Section: Introductionmentioning
confidence: 99%