A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD

Hawi, Ziarih; Matthews, Natasha; Barry, Edwina; Kirley, Aiveen; Wagner, Joe; Wallace, Robyn H.; Heussler, Helen; Vance, Alasdair; Gill, Michael; Bellgrove, Mark A.

doi:10.1007/s00213-012-2875-x

Cited by 30 publications

(24 citation statements)

References 30 publications

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“…This result is reported for the first time in the study by Brookes et al (2006). The association of MAO rs3027407 in this study was similar to the results of Brookes et al (2006) and Guan et al (2009), but was not similar to the result of Hawi et al (2013).…”

Section: Discussioncontrasting

confidence: 57%

“…ADHD, along with inattention, is known to demonstrate features of impulsivity and hyperactivity clinically (Brunner et al, 1993). Hawi et al (2013) conducted a large-scale study with 270 subjects having ADHD and 540 family members residing in Ireland and Australia. The result showed that MAOA rs3027407 single-nucleotide polymorphism (SNP) did not have a significant correlation with ADHD.…”

Section: Introductionmentioning

confidence: 99%

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Association Between Monoamine Oxidase Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children

Kwon

Jin²,

Lim³

2014

Genetic Testing and Molecular Biomarkers

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Attention deficit hyperactivity disorder (ADHD) is a common disorder of the school-age population. ADHD is familial and genetic studies estimate heritability at 80-90%. The aim of the present study was to investigate the association between the genetic type and alleles for the monoamine oxidase (MAO) gene in Korean children with ADHD. The sample consisted of 180 ADHD children and 159 control children. We diagnosed ADHD according to DSM-IV. ADHD symptoms were evaluated with Conners' Parent Rating Scales and Dupaul Parent ADHD Rating Scales. Blood samples were taken from the 339 subjects, DNA was extracted from blood lymphocytes, and polymerase chain reaction was performed for MAO polymorphism. Allele and genotype frequencies were compared using the chi-square test. We compared the allele and genotype frequencies of MAO gene polymorphism in the ADHD and control groups. This study showed that there was a significant correlation among the frequencies of the rs5906883 (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.08-2.00, p = 0.014) and the rs3027407 (OR = 1.41, 95% CI = 1.03-1.91, p = 0.029) alleles of MAO, but the final conclusions are not definite. Follow-up studies with larger patient or pure subgroups are expected. These results suggested that MAO might be related to ADHD symptoms.

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Section: Discussioncontrasting

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Association Between Monoamine Oxidase Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children

Kwon

Jin²,

Lim³

2014

Genetic Testing and Molecular Biomarkers

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“…The findings with regard to rs3785157 and ADHD diagnosis are in line with those of Bobb et al (2005), who reported the T allele to be preferentially transmitted in ADHD trios as compared to controls. Most recently, Hawi et al (2013) showed an increased transmission of the T allele just missing significance after permutation adjustment. However, several previous studies failed to replicate these findings (Brookes et al, 2006;Kim et al, 2008b), with one group detecting a trend for an association with ADHD, albeit for the C allele (Xu et al, 2005).…”

Section: Discussionmentioning

confidence: 98%

Association of norepinephrine transporter (NET, SLC6A2) genotype with ADHD-related phenotypes: Findings of a longitudinal study from birth to adolescence

Hohmann

Hohm

Treutlein

et al. 2015

Psychiatry Research

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“…Our recent work has indicated a significant association between the Irish ADHD sample and a SLC6A2 haplotype (Hawi et al 2013). We elected, therefore, to examine whether the investigated CES1 markers (of this study) were also associated with ADHD, as a consequence of potential linkage disequilibrium (LD) between two genes.…”

Section: Introductionmentioning

confidence: 97%

Methylphenidate Side Effect Profile Is Influenced by Genetic Variation in the Attention-Deficit/Hyperactivity Disorder-Associated CES1 Gene

Johnson

Barry

Lambert

et al. 2013

Journal of Child and Adolescent Psychopharmacology

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A high density linkage disequilibrium mapping in 14 noradrenergic genes: evidence of association between SLC6A2, ADRA1B and ADHD

Cited by 30 publications

References 30 publications

Association Between Monoamine Oxidase Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children

Association Between Monoamine Oxidase Gene Polymorphisms and Attention Deficit Hyperactivity Disorder in Korean Children

Association of norepinephrine transporter (NET, SLC6A2) genotype with ADHD-related phenotypes: Findings of a longitudinal study from birth to adolescence

Methylphenidate Side Effect Profile Is Influenced by Genetic Variation in the Attention-Deficit/Hyperactivity Disorder-Associated CES1 Gene

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