A high-fat diet during pregnancy impairs memory acquisition and increases leptin receptor expression in the hippocampus of rat offspring

Cortés-Álvarez, Nadia Yanet; Vuelvas-Olmos, César Rubén; Pinto-González, María Fernanda; Guzmán-Muñiz, Jorge; González-Pérez, Óscar; Moy-López, Norma Angélica

doi:10.1080/1028415x.2020.1728473

Cited by 11 publications

(6 citation statements)

References 59 publications

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“…Maternal hyperleptinemia has been suggested to induce leptin withdrawal in the fetal brain, resulting in the downregulation of leptin receptors and leptin signaling leading to cognitive impairment (Ding et al, 2018). Leptin receptors are expressed across multiple brain regions, such as the cortex, amygdala, hippocampus, thalamus, and hypothalamus, and it has been postulated that aberrant leptin signaling during development may negatively impact functions associated with these brain areas, such as memory, attention, or emotional control (Valleau and Sullivan, 2014;Cortes-Alvarez et al, 2020). However, some clinical studies did not find any effect on the cognitive abilities of the children of women with increased levels of leptin in the plasma (Li et al, 2019).…”

Section: Evidence Of Maternal Adipose Tissuefetal Brain Adipokine Axismentioning

confidence: 99%

The impact of maternal high-fat diet on offspring neurodevelopment

et al. 2022

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A maternal high-fat diet affects offspring neurodevelopment with long-term consequences on their brain health and behavior. During the past three decades, obesity has rapidly increased in the whole human population worldwide, including women of reproductive age. It is known that maternal obesity caused by a high-fat diet may lead to neurodevelopmental disorders in their offspring, such as autism spectrum disorder, attention deficit hyperactivity disorder, anxiety, depression, and schizophrenia. A maternal high-fat diet can affect offspring neurodevelopment due to inflammatory activation of the maternal gut, adipose tissue, and placenta, mirrored by increased levels of pro-inflammatory cytokines in both maternal and fetal circulation. Furthermore, a maternal high fat diet causes gut microbial dysbiosis further contributing to increased inflammatory milieu during pregnancy and lactation, thus disturbing both prenatal and postnatal neurodevelopment of the offspring. In addition, global molecular and cellular changes in the offspring’s brain may occur due to epigenetic modifications including the downregulation of brain-derived neurotrophic factor (BDNF) expression and the activation of the endocannabinoid system. These neurodevelopmental aberrations are reflected in behavioral deficits observed in animals, corresponding to behavioral phenotypes of certain neurodevelopmental disorders in humans. Here we reviewed recent findings from rodent models and from human studies to reveal potential mechanisms by which a maternal high-fat diet interferes with the neurodevelopment of the offspring.

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Section: Evidence Of Maternal Adipose Tissuefetal Brain Adipokine Axismentioning

confidence: 99%

The impact of maternal high-fat diet on offspring neurodevelopment

et al. 2022

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“…KD is also associated with the reduced protein intake. The lack of these macromolecules during pregnancy in rats reveal in persistent or reversible anatomical and functional changes to the brain of their pups, and may lead to the delay in the appearance of reflexes. , There is also a number of studies showing that a mother nutrition during pregnancy, especially high-fat diet, may affect the development of the progeny. − The numerous papers report negative effects of the exposure to such a diet at the prenatal stage. − However, there is also study suggesting that in utero exposure to high-fat diet may play a protective role for offspring brain health later in the adulthood …”

Section: Introductionmentioning

confidence: 99%

Does Ketogenic Diet Used in Pregnancy Affect the Nervous System Development in Offspring?─FTIR Microspectroscopy Study

Rugieł

Setkowicz-Janeczko

Kosiek

et al. 2023

ACS Chem. Neurosci.

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Anti-seizure medications used during pregnancy may have transient or long-lasting impact on the nervous system of the offspring. Therefore, there is a great need to search for alternative therapies for pregnant women suffering from seizures. One of the solutions may be the use of the ketogenic diet (KD), which has been successfully applied as a treatment of drug-resistant epilepsy in children and adults. However, the risks associated with the use of this dietary therapy during pregnancy are unknown and more investigation in this area is needed. To shed some light on this problem, we attempted to determine the potential abnormalities in brain biomolecular composition that may occur in the offspring after the prenatal exposure to KD. To achieve this, the female Wistar rats were, during pregnancy, fed with either ketogenic or standard laboratory diet, and for further studies, their male offspring at 2, 6, or 14 days of age were used. Fourier transform infrared microspectroscopy was applied for topographic and quantitative analysis of main biological macromolecules (proteins, lipids, compounds containing phosphate and carbonyl groups, and cholesterol) in brain samples. Performed chemical mapping and further semi-quantitative and statistical analysis showed that the use of the KD during pregnancy, in general, does not lead to the brain biochemical anomalies in 2 and 6 days old rats. The exception from this rule was increased relative (comparing to proteins) content of compounds containing phosphate groups in white matter and cortex of 2 days old rats exposed prenatally to KD. Greater number of abnormalities was found in brains of the 14 days old offspring of KD-fed mothers. They included the increase of the relative level of compounds containing carbonyl groups (in cortex as well as multiform and molecular cells of the hippocampal formation) as well as the decrease of the relative content of lipids and their structural changes (in white matter). What is more, the surface of the internal capsule (structure of the white matter) determined for this age group was smaller in animals subjected to prenatal KD exposure. The observed changes seem to arise from the elevated exposition to ketone bodies during a fetus life and the disturbance of lipid metabolism after prenatal exposure to the KD. These changes may be also associated with the processes of compensation of mother organism, which slowly began to make up for the deficiencies in carbohydrates postpartum.

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“…Meanwhile, some in vitro data also indicated that the proliferation and differentiation of offspring DG neural progenitors decreased under the influence of maternal HFD prior to and during pregnancy [ 20 ]. The offspring in adulthood exhibited decreased neurogenesis, apoptosis and neuronal differentiation [ 21 , 22 , 23 ] and impaired synaptic plasticity and memory [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal High-Fat Diet Reduces Type-2 Neural Stem Cells and Promotes Premature Neuronal Differentiation during Early Postnatal Development

et al. 2022

Nutrients

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Maternal obesity or exposure to a high-fat diet (HFD) has an irreversible impact on the structural and functional development of offspring brains. This study aimed to investigate whether maternal HFD during pregnancy and lactation impairs dentate gyrus (DG) neurogenesis in offspring by altering neural stem cells (NSCs) behaviors. Pregnant Sprague-Dawley rats were fed a chow diet (CHD) or HFD (60% fat) during gestation and lactation. Pups were collected on postnatal day 1 (PND 1), PND 10 and PND 21. Changes in offspring body weight, brain structure and granular cell layer (GCL) thickness in the hippocampus were analyzed. Hippocampal NSCs behaviors, in terms of proliferation and differentiation, were investigated after immunohistochemical staining with Nestin, Ki67, SOX2, Doublecortin (DCX) and NeuN. Maternal HFD accelerated body weight gain and brain structural development in offspring after birth. It also reduced the number of NSCs and their proliferation, leading to a decrease in NSCs pool size. Furthermore, maternal HFD intensified NSCs depletion and promoted neuronal differentiation in the early postnatal development period. These findings suggest that maternal HFD intake significantly reduced the amount and capability of NSCs via reducing type–2 NSCs and promoting premature neuronal differentiation during postnatal hippocampal development.

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A high-fat diet during pregnancy impairs memory acquisition and increases leptin receptor expression in the hippocampus of rat offspring

Cited by 11 publications

References 59 publications

The impact of maternal high-fat diet on offspring neurodevelopment

The impact of maternal high-fat diet on offspring neurodevelopment

Does Ketogenic Diet Used in Pregnancy Affect the Nervous System Development in Offspring?─FTIR Microspectroscopy Study

Maternal High-Fat Diet Reduces Type-2 Neural Stem Cells and Promotes Premature Neuronal Differentiation during Early Postnatal Development

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