A High-Fat Diet Induces Lower Systemic Inflammation than a High-Carbohydrate Diet in Mice

Almeida-Souza, C.B. de; Antunes, Marina Masetto; Carbonera, Fabiana; Godoy, Guilherme; Silva, Maria A R C P da; Masi, Laureane Nunes; Visentainer, Jesuı́ V.; Curi, Rui; Bazotte, Roberto Barbosa

doi:10.1089/met.2020.0116

Cited by 9 publications

(5 citation statements)

References 42 publications

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“…On the other hand, a high-fat diet with caloric restriction had a positive effect on plasma adipokine levels, glucose tolerance, lipid profile, and inflammation and oxidative stress in rats [6]. Other studies also confirm that the type of diet is one of the most important factors that can influence inflammation, metabolic responses, and behavior, including dietary habits [7][8][9][10].…”

Section: Introductionmentioning

confidence: 84%

Influence of Maternal Diet and Intergenerational Change in Diet Type on Ovarian and Adipose Tissue Morphology in Female Rat Offspring

et al. 2022

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Background and Objectives: A high-fat diet causes inflammation in the organism and many metabolic disorders. Adipose tissue secretes adipokines that affect the function of many organs. The health status of the mother before and during pregnancy affects the health of the offspring. The aim of this study was to determine how the type of maternal diet and the change in the type of diet in the offspring affects the histological characteristics of the ovaries and subcutaneous and perigonadal adipose tissue in female rat offspring. Materials and Methods: Ten female rats were divided into two groups. One group was fed standard laboratory chow, and the other was fed a high-fat diet and mated with a male of the same breed. The offspring of both groups of dams were divided into four subgroups with different feeding protocols. At 22 weeks of age, the offspring were sacrificed. Ovaries and subcutaneous and perigonadal adipose tissue were isolated. In the ovaries, the presence of cystic formations was investigated. Histomorphometric analysis was performed in two types of adipose tissue. Results: The weight of the ovaries of the offspring of mothers fed a high-fat diet was significantly higher than that of the offspring of mothers fed standard laboratory diets. Cystic formations were found in the ovaries of the offspring of mothers fed a high-fat diet. In subcutaneous adipose tissue, the percentage of small-sized adipocytes was significantly higher in the offspring of mothers fed standard laboratory diets. There were no significant differences in adipocyte surface area and adipocyte number between groups. Conclusion: Maternal diet influences the morphology of the ovaries and adipose tissue of the offspring.

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Section: Introductionmentioning

confidence: 84%

Influence of Maternal Diet and Intergenerational Change in Diet Type on Ovarian and Adipose Tissue Morphology in Female Rat Offspring

et al. 2022

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“…CSF2 is an important factor in the progression of liver fibrosis, and anti-CSF2 has been shown to ameliorate liver fibrosis [ 122 ]. CSF2 is increased in NASH patients and animal models of NASH [ 93 , 123 , 124 , 125 ]. Curcumin was reported to repress CSF2 in a concentration-dependent manner in allergic diseases [ 126 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Effect of Curcumin on Protein Targets in NAFLD Using Bioinformatic Analysis

et al. 2022

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BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder. Defects in function/expression of genes/proteins are critical in initiation/progression of NAFLD. Natural products may modulate these genes/proteins. Curcumin improves steatosis, inflammation, and fibrosis progression. Here, bioinformatic tools, gene–drug and gene-disease databases were utilized to explore targets, interactions, and pathways through which curcumin could impact NAFLD. METHODS: Significant curcumin–protein interaction was identified (high-confidence:0.7) in the STITCH database. Identified proteins were investigated to determine association with NAFLD. gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were analyzed for significantly involved targets (p < 0.01). Specificity of obtained targets with NAFLD was estimated and investigated in Tissue/Cells–gene associations (PanglaoDB Augmented 2021, Mouse Gene Atlas) and Disease–gene association-based EnrichR algorithms (Jensen DISEASES, DisGeNET). RESULTS: Two collections were constructed: 227 protein–curcumin interactions and 95 NAFLD-associated genes. By Venn diagram, 14 significant targets were identified, and their biological pathways evaluated. Based on gene ontology, most targets involved stress and lipid metabolism. KEGG revealed chemical carcinogenesis, the AGE-RAGE signaling pathway in diabetic complications and NAFLD as the most common significant pathways. Specificity to diseases database (EnrichR algorithm) revealed specificity for steatosis/steatohepatitis. CONCLUSION: Curcumin may improve, or inhibit, progression of NAFLD through activation/inhibition of NAFLD-related genes.

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“…Over the past few years, evidence has been accumulating that the emergence of cancer could be suppressed, or at least delayed by systematically controlling the amount of dietary CHOs, and the proliferation of already existing tumor cells could be slowed down 85‐87 . Relative to dietary fat, carbohydrate diets are more likely to cause inflammation 88 . And many cancers arise from sites of infection, chronic irritation and inflammation 89,90 .…”

Section: Carbohydratementioning

confidence: 99%

“…[85][86][87] Relative to dietary fat, carbohydrate diets are more likely to cause inflammation. 88 And many cancers arise from sites of infection, chronic irritation and inflammation. 89,90 These concepts promote CHO restriction instead of fat restriction to ameliorate harmful low-grade inflammation.…”

Section: Carbohydratementioning

confidence: 99%

The effect of diet and nutrition on T cell function in cancer

Zhou,

Wang,

Yuan

2023

Intl Journal of Cancer

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Cancer can be considered one of the most threatening diseases to human health, and immunotherapy, especially T‐cell immunotherapy, is the most promising treatment for cancers. Diet therapy is widely concerned in cancer because of its safety and fewer side effects. Many studies have shown that both the function of T cells and the progression of cancer can be affected by nutrients in the diet. In fact, it is challenging for T cells to infiltrate and eliminate cancer cells in tumor microenvironment, because of the harsh metabolic condition. The intake of different nutrients has a great influence on the proliferation, activation, differentiation and exhaustion of T cells. In this review, we summarize the effects of typical amino acids, lipids, carbohydrates and other nutritional factors on T cell functions and provide future perspectives for dietary treatment of cancer based on modifications of T cell functions.

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A High-Fat Diet Induces Lower Systemic Inflammation than a High-Carbohydrate Diet in Mice

Cited by 9 publications

References 42 publications

Influence of Maternal Diet and Intergenerational Change in Diet Type on Ovarian and Adipose Tissue Morphology in Female Rat Offspring

Influence of Maternal Diet and Intergenerational Change in Diet Type on Ovarian and Adipose Tissue Morphology in Female Rat Offspring

Investigation of the Effect of Curcumin on Protein Targets in NAFLD Using Bioinformatic Analysis

The effect of diet and nutrition on T cell function in cancer

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