A high-fat diet is deleterious to mice under glycolysis restriction

Abstract

It is debated whether carbohydrate restriction has metabolic advantage for its variable weight loss. Five-week-old male mice fed a high-fat diet receiving a glycolytic inhibitor, 2-deoxyglucose, led to an absolute mortality within 9 days. They exhibited greater decreases in rectal temperature, appetite and decline in body weight accompanied by increasing total cholesterol level than the other groups. This study suggests that carbohydrate is necessary for adequate physical and metabolic performance when lipid-rich diet is loaded.

Every-Other-Day Feeding Decreases Glycolytic and Mitochondrial Energy-Producing Potentials in the Brain and Liver of Young Mice

“…A third version of DR may place organisms on an intermittent fasting schedule, on feeding days they are not given food ad libitum , but receive lower amounts of food than the amount consumed on the AL regimen. Interestingly, although the first two approaches to DR mentioned above look different, they frequently result in similar changes in parameters such as body mass, temperature, heart rate, blood pressure, and levels of glucose and insulin (Le Couteur et al, 2016; Hao et al, 2018; Matyi et al, 2018). Diverse molecular mechanisms are supposed to be responsible for the beneficial DR effects, including down-regulation of insulin signaling, activation of metabolic processes and biogenesis of mitochondria, a decrease in steady-state levels of reactive oxygen species (ROS), and induction of cytoprotective stress responses (Gouspillou and Hepple, 2013; Pani, 2015).…”

A Low-Protein High-Fat Diet Leads to Loss of Body Weight and White Adipose Tissue Weight via Enhancing Energy Expenditure in Mice

“…It was reported that glucose metabolism was necessary for adequate metabolic performance when consuming a high-fat diet [ 68 ]. In soleus muscle, a HPHF diet increased glucose metabolism capacity by upregulating Hk2 and Pparγ .…”