A high fructose diet impairs spatial memory in male rats

Ross, Amy P.; Bartness, Timothy J.; Mielke, John G.; Parent, Marise B.

doi:10.1016/j.nlm.2009.05.007

Cited by 132 publications

(87 citation statements)

References 69 publications

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“…It is not wise to administer sugary beverages to dogs for the purposes of increasing persistence on a regular basis, as the chronic consumption of sugars has been linked to long-term neurodegeneration and decreased executive function (van der Borght et al, 2011;Ross et al, 2009). Thus, it would be useful if the results obtained here motivated research on the effects of other nutrients (that similarly activate the vagus nerve) on replenishment.…”

Section: Discussionmentioning

confidence: 99%

Self-regulatory depletion in dogs: Insulin release is not necessary for the replenishment of persistence

Miller

Pattison

Laude

et al. 2015

Behavioural Processes

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It has been hypothesized that self-control is constrained by a limited energy resource that can be depleted through exertion. Once depleted, this resource can be replenished by the consumption or even the taste of glucose. For example, the need to inhibit reduces subsequent persistence at problem solving by humans and dogs, an effect that is not observed when a glucose drink (but not placebo) is administered following initial inhibition. The mechanism for replenishment by glucose is currently unknown. Energy transfer is not necessary, though insulin secretion may be involved. This possibility was investigated in the current study by having dogs exert self-control (sit-stay) and subsequently giving them (1) glucose that causes the release of insulin, (2) fructose that does not result in the release of insulin nor does it affect glucose levels (but is a carbohydrate), or (3) a calorie-free drink. Persistence measures indicated that both glucose and fructose replenished canine persistence, whereas the calorie-free drink did not. These results indicate that insulin release is probably not necessary for the replenishment that is presumed to be responsible for the increase in persistence.(182 words)

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Section: Discussionmentioning

confidence: 99%

Self-regulatory depletion in dogs: Insulin release is not necessary for the replenishment of persistence

Miller

Pattison

Laude

et al. 2015

Behavioural Processes

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“…However it is well known that industrial fructose usage causes serious health problems in living organism. It is reported that fructose is taken into the body without being controlled by insulin, which creates dependency, causes cell aging, impairs spatial memory, metabolic syndrome, obesity and many pathologic illness [11][12][13] .…”

Section: Introductionmentioning

confidence: 99%

Endüstriyel Ticari Şekerlerin Farklı Şerbet Seviyeleri İle Beslenen Bal Arısı (Apis mellifera L.) Kolonilerinden Üretilmiş Katkılı ve Saf Balların Biyokimyasal Özellikler Yönünden Karşılaştırılması

Güler¹,

Garipoğlu²,

Önder³

et al. 2017

Kafkas Univ Vet Fak Derg

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In the present study, 100 pure and adulterated honey samples produced by feeding colonies with different levels (5, 20 and 100 L/colony) of various commercial industrial sugar syrups such as High Fructose Corn Syrup 85 (HFCS-85), High Fructose Corn Syrup 55 (HFCS-55), Glucose Monohydrate Sugar (GMS), Bee Feeding Syrup (BFS) and Sucrose Syrup (SS) were evaluated in terms of sugar ingredients, physicochemical, mineral matter, vitamin and enzyme contents. Proline, electrical conductivity, free acidity, vitamin, mineral and enzyme content of honey were significantly affected by sugar origin and syrup levels. Fructose and glucose content of honey were not reliable criteria for distinguishing adulterated honey obtained by overfeeding honey bees (100 L/colony syrup) with sugar having balanced monosaccharide fraction. For pure blossom honey having EC value below 0.20 mS/cm should be evaluated as indirect adulterated with commercial industrial sugars originating from both C3 and C4 plants. In addition, proline content of pure blossom honey below 300 mg/kg might be an indicator for overfeeding honey bee colonies with HFCS-85 and SS. It is clear that the important biochemical and biological degradation occurred in honey when the colonies overfed with industrial sugars syrup during the main nectar flow. The values of biochemical properties found in the present study are important references to be used for revision of national and international standards. şurupları ile glukoz monohydrate (GMS) ve sukroz (SS) şekerlerinin 5, 20 ve 100 litre/koloni şerbet seviyeleri ile üretilmiş hileli ve saf (PBH) 100 bal örneğinin biyokimyasal özellikleri değerlendirilmiştir. 100 bal örneği su, fruktoz, glukoz, F/G, F+G, Glukoz/Su, maltoz, laktoz, sukroz, kül, serbest asitlik, viskozite, hydroxymethyfurfural (HMF), diyastaz, invertaz, α-glukosidaz, glukoz oksidaz, proline, elektriki iletkenlik, Na, K, K/Na, vitamin B5 ve vitamin C yönünden karşılaştırılmıştır. Laktoz, maltoz ve glukosidaz enzimi dışındaki biyokimyasal özellikleri şeker çeşidi ve şerbet seviyesine göre önemli (P<0,001) farklılık göstermişlerdir. Arılar saf glukozmonohidrat şekerinden yararlanamamış fakat sukroz şekerini aşırı düzeyde severek tüketmişlerdir. Şeker içeriğinde monosakkarit yapıdaki fruktoz miktarı arttığında arı bunu izomerize edememiştir. Koloniye verilen şerbet miktarı arttıkça arılar daha fazla enzim üretememişlerdir. Şerbet miktarı arttıkça balın protein, enzim, vitamin, mineral madde ve şeker yapısı gibi çok önemli düzeyde biyokimyasal değişim ve biyolojik kayıp meydana gelmiştir. Prolin, asitlik, iletkenlik ve K/Na oranı aşırı besleme ile üretilen hileli balları tanımlamada önemli özelliklerdir. Biyokimyasal özelliklerin belirlenen değerleri mevcut ulusal ve uluslararası standartların düzenlenmesi için önemli referanslardır.

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“…A high fructose (HF) diet causes a number of pathological changes, including oxidative stress, obesity, metabolic syndrome, glucose intolerance, insulin resistance, type II diabetes, liver disease, hypertension and cardiovascular disease (CVD) (2). Unhealthy dietary habits can result in damage to brain health.…”

Section: Introductionmentioning

confidence: 99%

A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats

Madani

Malaisse²,

Ait-Yahia

2015

Biomedical Reports

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Abstract. The present study explored the potential of fish proteins to counteract high glucose levels and oxidative stress induced by fructose in the brain. A total of 24 male Wistar rats consumed sardine protein or casein with or without high fructose (64%). After 2 months, brain tissue was used for analyses. The fructose rats exhibited an increase in body mass index (BMI), body weight, absolute and relative brain weights and brain glucose; however, there was a decrease in food and water intake. Fructose disrupts membrane homeostasis, as evidenced by an increase in the brain hydroperoxides and a decrease in catalase (CAT) and glutathione peroxidase (GSH-Px) compared to the control. The exposure to the sardine protein reduced BMI, food intake, glucose and hydroperoxides, and increased CAT and GSH-Px in the brain. In conclusion, the metabolic dysfunctions associated with the fructose treatment were ameliorated by the presence of sardine protein in the diet by decreasing BMI, brain glucose and lipid peroxidation, and increasing CAT and GSH-Px activities.

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A high fructose diet impairs spatial memory in male rats

Cited by 132 publications

References 69 publications

Self-regulatory depletion in dogs: Insulin release is not necessary for the replenishment of persistence

Self-regulatory depletion in dogs: Insulin release is not necessary for the replenishment of persistence

Endüstriyel Ticari Şekerlerin Farklı Şerbet Seviyeleri İle Beslenen Bal Arısı (Apis mellifera L.) Kolonilerinden Üretilmiş Katkılı ve Saf Balların Biyokimyasal Özellikler Yönünden Karşılaştırılması

A comparison between the impact of two types of dietary protein on brain glucose concentrations and oxidative stress in high fructose-induced metabolic syndrome rats

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