2024
DOI: 10.1002/psc.3628
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A high hydrophobic moment arginine‐rich peptide screened by a machine learning algorithm enhanced ADC antitumor activity

Ruo‐Long Su,
Xue‐Wei Cao,
Jian Zhao
et al.

Abstract: Cell‐penetrating peptides (CPPs) with better biomolecule delivery properties will expand their clinical applications. Using the MLCPP2.0 machine algorithm, we screened multiple candidate sequences with potential cellular uptake ability from the nuclear localization signal/nuclear export signal database and verified them through cell‐penetrating fluorescent tracing experiments. A peptide (NCR) derived from the Rev protein of the caprine arthritis‐encephalitis virus exhibited efficient cell‐penetrating activity,… Show more

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