A high intake of dietary fiber influences C-reactive protein and fibrinogen, but not glucose and lipid metabolism, in mildly hypercholesterolemic subjects

Abstract

Our study suggests that a 5-week high dietary fiber intake of oat bran, rye bran, and sugar beet fiber might reduce the low-grade inflammatory response measured as CRP which could, together with reduced fibrinogen, help to prevent the risk of cardiovascular disease.

Effect of dietary fiber on circulating C-reactive protein in overweight and obese adults: a meta-analysis of randomized controlled trials

“…Analyses examining the influence of an individual trial on the overall effect size by omitting one trial in each turn yielded a range of À0.47 (95% CI À0.85, À0.08) to À0.23 (95% CI À0.66 to 0.20). The overall effect size became non-significant after excluding the study of King et al (2007), Katcher et al (2008), or Johansson-Persson (2014, which had an obvious reduction of CRP after fiber intervention.…”

“…Despite the significant reduction in CRP levels after dietary fiber intake, clinical benefits that are related to such small absolute CRP changes are difficult to assess. The sensitivity analysis also showed that the significant result was dependent on some studies that reported obvious reduction in CRP, particularly the study of Johansson-Persson (2014) showing the highest weight in metaanalysis. This study had a relatively high design quality (Jadad score ¼ 4) and had the greatest total fiber difference between the intervention and control groups (17.8 g/d).…”

“…Most were excluded by screening abstracts or titles. After assessing the full text of 35 eligible studies, we finally yielded 14 RCTs ( Figure 1) (Andersson et al, 2007;Brownlee et al, 2010;Dall'Alba et al, 2013;de Mello et al, 2011;Georg Jensen et al, 2012;Jenkins et al, 2002;Johansson-Persson et al, 2014;Katcher et al, 2008;King et al, 2007King et al, , 2008Kohl et al, 2009;Kristensen et al, 2012;Rhee & Brunt, 2011;Wood et al, 2006). The main reasons for further exclusion were as follows: (1) the participants were not overweight/obese adults; (2) the study design was not RCT; and (3) the data were insufficient to calculate CRP changes.…”

Short-chain fatty acids, prebiotics, synbiotics, and systemic inflammation: a systematic review and meta-analysis

“…Of the 2 studies investigating the effect of resistant starch supplementation (58, 81), 1 reported a significant decrease in inflammation (TNF-a and IL-6) (58). A significant decrease in CRP was reported following a high-(10.7 g) compared with low-soluble fiber (2.5 g) diet (31), with an inverse association between soluble fiber intake and systemic inflammation (IL-6: P = 0.004 and TNF-a-R2: P = 0.02) observed in the crosssectional study by Ma et al (2).…”

Cereal bran fortified-functional foods for obesity and diabetes management: Triumphs, hurdles and possibilities

“…The controlled, randomized study spanning 5 weeks revealed significant reduction in C-reactive protein and fibrinogen. It was suggested that the fibre combination might reduce the low-grade inflammatory response and prevent the risk of cardiovascular disease (Johansson-Persson et al, 2014). Heat pretreatment and enzymatic hydrolysis of rye bran yielded arabinoxylanoligosaccharides with functional food potential (Falck et al, 2014).…”