A High Molecular Mucopolysaccharide Peptide Complex Stimulating Connective Tissue Metabolism

Kalbhen, D.A.; Karzel, K; Domenjoz, R

doi:10.1159/000135941

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…, Comparable results were reported by other authors using different experimental systems [Domenjoz, 1966], In further publications it was shown that a cartilage extract seems to exert stimulating influences on mucopolysaccharide release by fibroblasts cultured in vitro [Karzel and D omenjoz, 1963; Karzel et al, 1966;Kalbhen et al, 1966Kalbhen et al, , 1968.…”

mentioning

confidence: 59%

Effects of Hexosamine Derivatives and Uronic Acid Derivatives on Glycosaminoglycane Metabolism of Fibroblast Cultures

Karzel¹,

Domenjoz²

1971

Pharmacology

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The influence of glucosamine, galactosamine, glucuronic acid and of some derivatives of these compounds on mucopolysaccharide metabolism and on protein metabolism of primary fibroblast monolayer cultures was studied. Glucosamine, glucosamine · HC1, glucosamine · HJ and glucosamine sulfate (in concentrations of 100 µg/ml each) caused a considerable, statistically highly significant increase of the secretion of mucopolysaccharides by the fibroblasts. N-Acetylglucosamine and N-acetylgalactosamine were effective too, though to a lesser degree. Glucuronic acid was without any influence on mucopolysaccharide production. The protein content of the cultures was not affected by the 7 compounds mentioned so far in concentrations of up to 100 µg/ml. Galactosamine and betaineglucuronate induced a certain depression of a mucopolysaccharide production and simultaneously a decrease of the cellular protein content.

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mentioning

confidence: 59%

Effects of Hexosamine Derivatives and Uronic Acid Derivatives on Glycosaminoglycane Metabolism of Fibroblast Cultures

Karzel¹,

Domenjoz²

1971

Pharmacology

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“…It has been shown to stimulate anabolism in cartilage tissue of normal animals [2,3] and mucopolysaccharide biosynthesis by fibroblasts [4]. Certainly there are no known agents which have been shown conclusively to influence joint repair in such degenerative conditions.…”

Section: Editorial On: Restorative Chemotherapy In Degenerative Hip Dmentioning

confidence: 99%

Editorial

1978

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Pharmakologische Studien über experimentell ausgelöste Gelenkdegenerationen (Arthrosen) beim Versuchstier und ihre Therapie mit einem Mucopolysaccharid-Peptid Komplex

Altwein¹

1980

Die Experimentelle Arthrose Und Ihre Verwendung in Der Pharmakologie

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A High Molecular Mucopolysaccharide Peptide Complex Stimulating Connective Tissue Metabolism

Cited by 7 publications

References 5 publications

Effects of Hexosamine Derivatives and Uronic Acid Derivatives on Glycosaminoglycane Metabolism of Fibroblast Cultures

Effects of Hexosamine Derivatives and Uronic Acid Derivatives on Glycosaminoglycane Metabolism of Fibroblast Cultures

Editorial

Pharmakologische Studien über experimentell ausgelöste Gelenkdegenerationen (Arthrosen) beim Versuchstier und ihre Therapie mit einem Mucopolysaccharid-Peptid Komplex

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