A high monocyte-to-lymphocyte ratio predicts poor prognosis in patients with radical cystectomy for bladder cancer

Shi, Heng; Wang, Keyi; Yuan, Jing; Mao, Weipu; Wu, Zong-Lin; Liu, Qunlong; Xie, Jinbo; Peng, Bo

doi:10.21037/tcr-20-1060

Cited by 5 publications

(2 citation statements)

References 37 publications

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“…The variation in RHOJ expression across different immune cell populations indicates its potential impact on the tumor immune microenvironment, highlighting its significance in cancer immunotherapy. Notably, patients undergoing radical cystectomy for bladder cancer with a high monocyte to lymphocyte ratio are likely to have a poorer prognosis [ 45 , 46 ]. Overexpression of RHOJ can elevate the mRNA and protein levels of the pro-inflammatory vascular cell adhesion molecule 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1) in endothelial cells (ECs).…”

Section: Discussionmentioning

confidence: 99%

Elucidating the Associated Biological Function and Clinical Significance of RHOJ Expression in Urothelial Carcinoma

Lu,

Lai,

et al. 2023

IJMS

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Urothelial cancer, a common urinary system malignancy, often presents treatment challenges due to metastasis and chemotherapy side effects. Angiogenesis, crucial for tumor growth, has become a target for drug development. This study explores the expression, prognostic value, and clinical correlation of RHOJ in the TCGA BLCA, GSE31684, and GSE32894 datasets. We identify common differentially expressed genes across these databases and utilize g:Profiler and Cytoscape ClueGO for functional assessment. Further, we perform a gene set enrichment analysis (GSEA) using Hallmark gene sets and use the imsig package for immune cell infiltration analysis. Our analysis indicates that RHOJ expression levels significantly impact survival rates, tumor progression, and immune response in urothelial tumors. High RHOJ expression correlated with poor prognosis, advanced disease stages, and an increase in monocyte population within the tumor microenvironment. This aligns with current literature indicating a key role of immune infiltration in bladder cancer progression and treatment response. Moreover, the GSEA and imsig results further suggest a potential mechanistic link between RHOJ expression and immune-related pathways. Considering the increasing emphasis on immunotherapeutic strategies in bladder cancer management, our findings on RHOJ’s potential as a diagnostic biomarker and its association with immune response open new avenues for therapeutic interventions.

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Section: Discussionmentioning

confidence: 99%

Elucidating the Associated Biological Function and Clinical Significance of RHOJ Expression in Urothelial Carcinoma

Lu,

Lai,

et al. 2023

IJMS

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“…The monocyte-to-lymphocyte ratio (MLR) is a novel inflammatory biomarker that integrates the effects of both inflammatory markers. It has high predictive and prognostic value in various cancers, including hepatocellular carcinoma, gastrointestinal stromal tumor, endometrial cancer, bladder cancer, and breast cancer (Cananzi et al, 2019;Shi et al, 2020;Song et al, 2021;Tiainen et al, 2021;Wang Q. et al, 2022). To our interest, the significance of MLR in PCa has also been confirmed.…”

Section: Introductionmentioning

confidence: 99%

Association between monocyte-to-lymphocyte ratio and prostate cancer in the U.S. population: a population-based study

Wang,

Li,

Liu

et al. 2024

Front. Cell Dev. Biol.

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Introduction:Monocyte-to-lymphocyte ratio (MLR) is a convenient and noninvasive inflammatory biomarker, and inflammation has been reported to be associated with prostate cancer (PCa). Our objective was to ascertain any possible correlation between PCa and MLR.Methods:We utilized data from the 1999–2020 cycles of the National Health and Nutrition Examination Survey (NHANES) regarding MLR and PCa. The independent associations of MLR and other inflammatory biomarkers (platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), system inflammation response index (SIRI), and aggregate index of systemic inflammation (AISI)) with PCa was investigated using weighted multivariate logistic regression and generalized additive models. Receiver operating characteristic (ROC) curves were conducted to evaluate and contrast their diagnostic capabilities.Results:The analysis we conducted comprised 25,367 persons in total. The mean MLR was 0.31 ± 0.14. The prevalence of PCa was 3.1%. A positive association was found between MLR and PCa (OR = 2.28; 95% CI: 1.44, 3.62). According to the interaction tests, age, body mass index (BMI), hypertension, diabetes, and smoking status did not significantly impact the relationship between MLR and PCa (all p for interaction >0.05). ROC analysis showed that MLR had a stronger discriminative ability and accuracy in predicting PCa than other inflammatory biomarkers (NLR, SII, AISI, PLR, and SIRI).Conclusion:MLR might be better than other inflammatory biomarkers (NLR, SIRI, AISI, PLR, and SII) in predicting PCa. American adults who have elevated levels of MLR, NLR, PLR, SII, and AISI should be aware that they have a greater risk of PCa.

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Preoperative monocyte-to-lymphocyte ratio as a potential predictor of bladder cancer

Napolitano

Barone

Reccia

et al. 2022

Journal of Basic and Clinical Physiology and Pharmacology

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Objectives The aim of this study was to investigate the role of preoperative Monocyte-to-Lymphocyte ratio (MLR) as a potential predictor of bladder cancer (BC). Methods Clinical data of patients who underwent TURBT at our institution between 2017 and 2021 were collected and retrospectively analysed. MLR was obtained from preoperative blood analyses performed within 1 month from hospital admission. The association of MLR with different clinic-pathological features obtained from histological reports was further analysed. Statistical analysis was performed using the Kruskal Wallis test for non-parametric variables, assuming p<0.05 as statistically significant. Results 510 patients were included in the study (81% males, 19% females), with a mean age of 71.66 ± 11.64 years. Mean MLR was higher in patients with any-type bladder cancer, reporting an MLR of 0.41 ± 0.11 compared to 0.38 ± 0.43 in patients without bladder cancer (p=0.043). In the subsequent comparison among low-grade and high-grade bladder cancer, MLR did not report statistically significant differences, with 0.29 ± 0.12 for low-grade BC and 0.51 ± 0.81 for high-grade BC (p=0.085) Conclusions Our findings reported elevated preoperative MLR should be considered a potential biomarker predicting malignancy for bladder tumours. Furthermore, research are necessary to assess its role in discerning low-grade from high-grade patients.

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A high monocyte-to-lymphocyte ratio predicts poor prognosis in patients with radical cystectomy for bladder cancer

Cited by 5 publications

References 37 publications

Elucidating the Associated Biological Function and Clinical Significance of RHOJ Expression in Urothelial Carcinoma

Elucidating the Associated Biological Function and Clinical Significance of RHOJ Expression in Urothelial Carcinoma

Association between monocyte-to-lymphocyte ratio and prostate cancer in the U.S. population: a population-based study

Preoperative monocyte-to-lymphocyte ratio as a potential predictor of bladder cancer

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