A High Monocyte-to-Lymphocyte Ratio Predicts Poor Prognosis in Patients with Advanced Gallbladder Cancer Receiving Chemotherapy

Choi, Yong‐Kook; Lee, Jae Woo; Lee, Sang Hyub; Kang, Jong Won; Lee, Ban Seok; Paik, Woo Hyun; Ryu, Ji Kon; Kim, Yong Tae

doi:10.1158/1055-9965.epi-18-1066

Cited by 36 publications

(38 citation statements)

References 31 publications

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“…The results above strongly suggest that stromal NNMT plays an important role in the progression of CRC. With the exception of a recent study in ovarian cancer, previous studies have not clarified the relationship between stromal NNMT expression and progression of cancer patients. With a cut‐off value of 106 for the IHC‐score of stromal NNMT, we classified 967 CRC patients into two subgroups with high or low stromal NNMT tumors.…”

Section: Discussionmentioning

confidence: 92%

“…The Maxstat package was used to identify the optimal cut-off value of the IHC score to define risk subgroups. 21 The Kaplan-Meier curves were used to estimate the DSS and DFS, and the survival curves was compared by the log-rank test. The hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were estimated by Cox proportional hazards models.…”

Section: Discussionmentioning

confidence: 99%

“…A descriptive summary of the clinicopathological features was performed using independent Student t test (for continuous variables) and Pearson Chi‐square test (for categorical variables). The Maxstat package was used to identify the optimal cut‐off value of the IHC score to define risk subgroups . The Kaplan‐Meier curves were used to estimate the DSS and DFS, and the survival curves was compared by the log‐rank test.…”

Section: Methodsmentioning

confidence: 99%

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High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer

Song

Miao

et al. 2020

Cancer Medicine

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Purpose Nicotinamide n‐methyltransferase (NNMT) has good biochemical activity and epigenetic regulation, and has been reported as a major metabolic regulator of cancer. The goal of this study was to investigate the significance of stromal NNMT expression in colorectal cancer (CRC). Patients and methods Stromal expression of NNMT in primary CRC, metastasis CRC, and their non‐cancerous tissues from 1088 CRC patients was examined by immunohistochemistry. The associations between stromal NNMT expression and survival outcomes in 967 patients with stage I‐III CRC were further evaluated with Kaplan‐Meier curve and Cox model analyses. Results NNMT expression was mainly sourced from stromal compartments and also elevated in CRC. Patients with high stromal NNMT (IHC‐score ≥ 106) have a worse survival than those patients with low stromal NNMT. In multiple Cox analyses, high expression of stromal NNMT remained as an independent risk factor in CRC for disease‐free survival with a hazard ratio (HR) of 1.415 (95% confidence interval [CI], 1.015‐1.972) and disease‐specific survival with a HR of 5.004 (95% CI, 2.301‐10.883). In addition, high stromal NNMT expression in CRC also indicates the poor survival outcomes in patients with early stage CRC (stage I and II) and in patients who undergo chemotherapy. Conclusion NNMT is mainly located in CRC stromal compartment. High stromal NNMT expression predicts an unfavorable postoperative prognosis.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer

Song

Miao

et al. 2020

Cancer Medicine

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“…Accumulating evidence implies that inflammation acts an absolutely required part in the formation of neoplasm possibly via all kinds of transcription factors, chemokines, as well as cytokines [10,11]. In many published knowledges, the roles of inflammatory factors like neutrophil-to-lymphocyte ratio (NLR) [48], monocyte-to-lymphocyte ratio (MLR) [49], and C-reactive protein (CRP) [50] have always been delineated in patients who suffered from cancer. Given that, we turned our attention on the association between another inflammatory immune factors, platelet-to-lymphocyte ratio (PLR), and gynecological cancer.…”

Section: Discussionmentioning

confidence: 99%

Prognostic function of platelet-to-lymphocyte ratio in gynecologic cancers: A systematic review and meta-analysis

Fan

Dai

Wang

et al. 2019

Preprint

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Background: Although along with the diagnosis and treatment level enhanced, current situation of the gynecologic malignancies improved, the risk of gynecologic tumor remains high. Nowadays, inflammatory markers increasingly employed as a tumor predictive factor. Herein, we focused on the association between the platelet-to-lymphocyte ratio (PLR) and gynecological cancers, including cervical, ovarian, and endometrial cancer. Methods: In this meta-analysis, we searched systematically on the EMBASE and PubMed databases from June 1, 1989 to May 31, 2019. After excluded some unqualified articles, we calculated the pooled hazard ratio (HR) with 95% confidence interval (CI) mainly to detect the relationship between PLR and prognostic survival, including overall survival (OS) and progression-free survival (PFS). Random-effect model was adopted when I 2 >50% after Higgins I 2 test. Subgroup analysis and funnel plot were used to seek for the possible source of heterogeneity and publication bias, respectively. All statistical tests were two-sided. Results: After a series of searching and selection, twenty-eight literatures containing 8290 participants totally. Among those recruited trials, 26 studies comprising 8109 patients reported HR for OS and 15 researches enrolled 4283 patients for PFS. Overall, a high value of PLR means a worse OS and PFS in women with gynecologic cancer except those with endometrial cancer for OS (pooled HR =1.35, 95% CI =0.73 to 2.53, P =0.33). Subgroup analyses indicated that the source of heterogeneity may be primarily from the sample size, PLR cut-off, study location, published year, and the cut-off year for the study. Publication bias manifested that bias was not evident. Conclusion: Elevated pretreatment PLR portends a poor prognosis among patients with gynecological tumor, as well as in women with cervical and ovarian malignancies for both OS and PFS. However, in patients with endometrial cancer, this connection is broken for OS but still available for PFS.

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“…Recently, various serum markers, including the leukocyte differentials and neutrophil/lymphocyte ratio (NLR) have been evaluated as surrogate markers for predictive and prognostic values in various entities, such as rheumatoid arthritis, pancreatitis, and several malignancies [10][11][12][13]. Recent research focusing on cost-effective biomarkers in IBD has reinvigorated the examination of white blood cell patterns, and a few studies have showed the potential of neutrophil and lymphocyte counts and their ratio to assess the disease activity either in UC or CD [14,15].…”

Section: Introductionmentioning

confidence: 99%

Correlation between Serological Biomarkers and Disease Activity in Patients with Inflammatory Bowel Disease

Cen

Chen

et al. 2019

BioMed Research International

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Background. Current biomarkers have been routinely used noninvasive methods for assessing disease activity of inflammatory bowel disease (IBD), but none of them are specific. This study was aimed to determine the performance of the serological biomarkers for detecting disease activity in patients with IBD. Methods. A prospective study that included 73 ulcerative disease (UC) subjects, 141 Crohn’s disease (CD) subjects, and 30 of them complicated with C. difficile infection (CDI) were diagnosed at a single-institution IBD center. Disease activity was assessed using by Truelove and Witts criteria for UC and Harvey Bradshaw Simple Index for CD. Serological inflammatory biomarkers were compared in different severity groups. Receiver operator curve analyses assessed the performance of each biomarker in discriminating disease states. Results. For UC patients, elevated monocyte counts, C-reactive protein (CRP), and decreased lymphocyte counts and lymphocyte/monocyte ratio (LMR) significantly differed between subjects with active and inactive UC. LMR of 3.1 was 76% sensitive and had a specificity of 67% for active UC. For CD patients, higher values of neutrophils, monocytes, neutrophil/lymphocyte ratio, CRP, fibrinogen, and lower values of LMR and hemoglobin were significantly different between subjects with active and inactive CD. None of the biomarkers included had a good correlation with disease activity (area under the ROC Curve < 0.70). Conclusions. A low LMR represents an inexpensive, readily available test with a promising value to identify disease activity in UC patients, whereas none of the inflammatory biomarkers showed a discriminative value in disease activity of CD.

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A High Monocyte-to-Lymphocyte Ratio Predicts Poor Prognosis in Patients with Advanced Gallbladder Cancer Receiving Chemotherapy

Cited by 36 publications

References 31 publications

High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer

High stromal nicotinamide N‐methyltransferase (NNMT) indicates poor prognosis in colorectal cancer

Prognostic function of platelet-to-lymphocyte ratio in gynecologic cancers: A systematic review and meta-analysis

Correlation between Serological Biomarkers and Disease Activity in Patients with Inflammatory Bowel Disease

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