A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy

Zhao, Wei; Fu, Chao; Gao, Hanyi; Zhou, Yizhao; Yan, Caihong; Yin, Yuli; Hu, Rong; Tang, Ben Zhong

doi:10.1039/d3qm00842h

Cited by 6 publications

(3 citation statements)

References 30 publications

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“…These sonosensitizers are nontoxic without ultrasound treatment but exhibit cell cytotoxicity through ROS production or other means. Some representative small-molecular organic sonosensitizers include (Scheme ): (1) porphyrin derivatives such as protoporphyrin IX (PPIX), ,− hematoporphyrin monomethyl ether (HMME), , Chlorin e6 (Ce6), and ATX-70; (2) xanthene-based sensitizers such as Rose Bengal (RB) and its derivatives; , (3) indocyanine-based structures such as IR-780 and indocynine green (ICG); (4) aggregation-induced emission (AIE) molecules; , (5) conjugated polymers; (6) others compounds such as methylene blue, and hypocrellin B . Moreover, inorganic nanomaterials-based sonosensitizers such as TiO 2 nanoparticles have also been reported to generate ROS under ultrasound irradiation .…”

Section: Sonodynamic Therapy Approaches Toward Prodrug Activationmentioning

confidence: 99%

Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy

Fu,

2024

ACS Appl. Bio Mater.

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Ultrasound has gained prominence in biomedical applications due to its noninvasive nature and ability to penetrate deep tissue with spatial and temporal resolution. The burgeoning field of ultrasound-responsive prodrug systems exploits the mechanical and chemical effects of ultrasonication for the controlled activation of prodrugs. In polymer mechanochemistry, materials scientists exploit the sonomechanical effect of acoustic cavitation to mechanochemically activate force-sensitive prodrugs. On the other hand, researchers in the field of sonodynamic therapy adopt fundamentally distinct methodologies, utilizing the sonochemical effect (e.g., generation of reactive oxygen species) of ultrasound in the presence of sonosensitizers to induce chemical transformations that activate prodrugs. This crossdisciplinary review comprehensively examines these two divergent yet interrelated approaches, both of which originated from acoustic cavitation. It highlights molecular and materials design strategies and potential applications in diverse therapeutic contexts, from chemotherapy to immunotherapy and gene therapy methods, and discusses future directions in this rapidly advancing domain.

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Section: Sonodynamic Therapy Approaches Toward Prodrug Activationmentioning

confidence: 99%

Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy

Fu,

2024

ACS Appl. Bio Mater.

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“…Notably, noncovalent π−π stacking is also instrumental in drug loading for delivery systems 681−683 and in the selfassembly of micro-/nanoscale systems. 684 Anticancer compounds, 685 sonosensitizers, 686 and biomacromolecules 687,688 have been effectively encapsulated into delivery systems through π−π interactions. This interaction has also been harnessed for the self-assembly of novel delivery systems using diverse materials like graphene-based materials, carbon-based substances, micelles, and hydrogels.…”

Section: π−π Stackingmentioning

confidence: 99%

“…This finding revises the conventional understanding of noncovalent π–π stacking interactions, extending the substrates beyond carbon-based materials to transition metal oxides, and proposes a novel approach to leverage the surface chemistry of micro-/nanomaterials via noncovalent π–π stacking. Notably, noncovalent π–π stacking is also instrumental in drug loading for delivery systems − and in the self-assembly of micro-/nanoscale systems . Anticancer compounds, sonosensitizers, and biomacromolecules , have been effectively encapsulated into delivery systems through π–π interactions.…”

Section: Synthesis and Construction Of Ultrasound-based Micro-/nanosy...mentioning

confidence: 99%

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Huang,

Zheng,

Chang

et al. 2024

Chem. Rev.

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Due to the intrinsic non-invasive nature, cost-effectiveness, high safety, and real-time capabilities, besides diagnostic imaging, ultrasound as a typical mechanical wave has been extensively developed as a physical tool for versatile biomedical applications. Especially, the prosperity of nanotechnology and nanomedicine invigorates the landscape of ultrasound-based medicine. The unprecedented surge in research enthusiasm and dedicated efforts have led to a mass of multifunctional micro-/nanosystems being applied in ultrasound biomedicine, facilitating precise diagnosis, effective treatment, and personalized theranostics. The effective deployment of versatile ultrasound-based micro-/nanosystems in biomedical applications is rooted in a profound understanding of the relationship among composition, structure, property, bioactivity, application, and performance. In this comprehensive review, we elaborate on the general principles regarding the design, synthesis, functionalization, and optimization of ultrasound-based micro-/nanosystems for abundant biomedical applications. In particular, recent advancements in ultrasound-based micro-/nanosystems for diagnostic imaging are meticulously summarized. Furthermore, we systematically elucidate state-of-the-art studies concerning recent progress in ultrasound-based micro-/nanosystems for therapeutic applications targeting various pathological abnormalities including cancer, bacterial infection, brain diseases, cardiovascular diseases, and metabolic diseases. Finally, we conclude and provide an outlook on this research field with an in-depth discussion of the challenges faced and future developments for further extensive clinical translation and application.

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Sonodynamic Therapy‐Driven Immunotherapy: Constructing AIE Organic Sonosensitizers Using an Advanced Receptor‐Regulated Strategy

Tian,

Li,

et al. 2024

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Benefit from the deeper penetration of mechanical wave, ultrasound (US)‐based sonodynamic therapy (SDT) executes gratifying efficacy in treating deep‐seated tumors. Nevertheless, the complicated mechanism of SDT undeniably hinders the exploration of ingenious sonosensitizers. Herein, a receptor engineering strategy of aggregation‐induced emission (AIE) sonosensitizers (TPA‐Tpy) with acceptor (A)‐donor (D)‐A’ structure is proposed, which inspects the effect of increased cationizations on US sensitivity. Under US stimulation, enhanced cationization in TPA‐Tpy improves intramolecular charge transfer (ICT) and accelerates charge separation, which possesses a non‐negligible promotion in type I reactive oxygen species (ROS) production. Moreover, abundant ROS‐mediated mitochondrial oxidative stress triggers satisfactory immunogenic cell death (ICD), which further promotes the combination of SDT and ICD. Subsequently, subacid pH‐activated nanoparticles (TPA‐Tpy NPs) are constructed with charge‐converting layer (2,3‐dimethylmaleic anhydride‐poly (allylamine hydrochloride)‐polyethylene glycol (DMMA‐PAH‐PEG)) and TPA‐Tpy, achieving the controllable release of sonosensitizers. In vivo, TPA‐Tpy‐mediated SDT effectively initiates the surface‐exposed of calreticulin (ecto‐CRT), dendritic cells (DCs) maturation, and CD8+ T cell infiltration rate through enhanced ROS production, achieving suppression and ablation of primary and metastatic tumors. This study provides new opinions in regulating acceptors with eminent US sensitization, and brings a novel ICD sono‐inducer based on SDT to realize superior antitumor effect.

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A high performance AIE-active sonosensitizer for efficient sonodynamic tumor therapy

Abstract: An organic sonosensitizer bearing a low-energy gap and aggregation-induced emission features was constructed for efficient tumor therapy based on ultrasound irradiation triggered-ROS generation.

Cited by 6 publications

References 30 publications

Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy

Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy

Ultrasound-Based Micro-/Nanosystems for Biomedical Applications

Sonodynamic Therapy‐Driven Immunotherapy: Constructing AIE Organic Sonosensitizers Using an Advanced Receptor‐Regulated Strategy

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