A High‐Performance Magnetic Resonance Imaging T₂ Contrast Agent

Heat dissipation and magnetic properties of surface-coated Fe3O4 nanoparticles for biomedical applications

“…Then, PO chain of Pluronic F-127, which is in the middle of the Pluronic F-127 molecule, gets associated with the alkyl tails of oleic acid molecules through hydrophobic interactions. The hydrophilicity of two EO chains thereby solubilized the particles in the aqueous media [7].…”

“…Pluronic has a synonymous chemical structure and higher molecular weight than poly(ethylene glycol), which is expected for drug delivery systems. Pluronic has attractive characteristics for drug delivery systems, such as biocompatibility [7] and prolonged blood-circulation time [8].…”

Dual targeting strategy of magnetic nanoparticle-loaded and RGD peptide-activated stimuli-sensitive polymeric micelles for delivery of paclitaxel

“…Carboxylic acid-coated SPIONs, with average diameter of 10 nm, were prepared by a one-pot thermolysis with strictly controlled molar ratio of Fe salts and OA (Lin and Kim 2012;Yang et al 2009;Qin et al 2009a). The hydrophobic carbon chain of OASPIONs form an interstitial layer with PLA segment via hydrophobic interaction, in which hydrophobic low Mw drug PTX resides, and the PNA forms a hydrated corona surrounding the hydrophobic core (Qin et al 2007(Qin et al , 2009b. The freeze-drying process is essential to remove the trace amount of chloroform solvent, which may be present in the hydrophobic core of the small micelle-like structure and cause further harmful reaction.…”

“…In this study, OA-SPIONs were transferred into water with the assistance of the amphiphilic polymer PNAL, in which OA-SPIONs and low Mw drug PTX are encapsulated in the hydrophobic PLA segments and hydrophilic PNA forms a hydrated corona surrounding the PLA core (Qin et al 2007(Qin et al , 2009b. However, instead of forming small micelle-like nanostructures that contain only the water-free hydrophobic aggregates formed by the single iron oxide nanocrystals, usually one micelle-like particle encapsulates hundreds of SPIONs.…”

“…Superparamagnetic iron oxide nanoparticles (SPIONs) are promising candidates for multifunctional nanocarriers in cancer-oriented diagnosis and therapy, because of their unique and fascinating superparamagnetism Li et al 2014). SPIONs have demonstrated significant improvement as T 2 contrast agents over conventional Gd complexes, (Qin et al 2007) and they also showed promising potentials as targeted drug carriers for in vivo drug delivery, attributed to the capability of being localized and concentrated at the target site by the applied magnetic field once injected systematically (Yoon et al 2005).…”