A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer

Williams, Christina D.; Whitley, Brian; Hoyo, Cathrine; Grant, Delores J.; Iraggi, Jared; Newman, Kathryn A.; Gerber, Leah; Taylor, Loretta; McKeever, Madeline G.; Freedland, Stephen J.

doi:10.1016/j.nutres.2011.01.002

Cited by 160 publications

(121 citation statements)

References 38 publications

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“…According to Russo (2009) and Williams et al (2011), lowering linoleic:linolenic acid value in human diets towards one increases protection against certain degenerative pathologies, but since some of the most common oils in human diets such as soybean, corn, sunflower and safflower are all rich in linoleic acid, the balance between linoleic and linolenic acids can be achieved by incorporating more dietary sources abundant in linolenic acid, such as linseed and rapeseed oil, as well as fish and shellfish (Russo, 2009). As a result of all aforementioned, the changes occurring in consumer preferences for soybean oil and the world market for oilseed products becoming ever more competitive, the emphasis in breeding soybean should be put not only on increasing seed yield as the main objective for all breeding programmes, but also on increasing soybean oil quality and modifying the fatty acid composition to meet the demands of industry and end-users alike (Hemingway et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Screening of early maturing soybean genotypes for production of high quality edible oil

Kočar

Sudarić

Sudar

et al. 2018

Zemdirbyste-Agriculture

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The usage and value of soybean (Glycine max (L.) Merr.) seed oil are mainly determined by its fatty acid composition, which affects physical, chemical and nutritional properties. In order to assess genotypes' suitability for edible oil production and determine the variability in phenotypic expression of the amount of oil and fatty acid composition in the seed, three-year (2010-2012) trials were set up with eight early maturing advanced soybean lines. As a result, we determined the amount of seed oil and composition of seed fatty acids (palmitic, stearic, oleic, linoleic and linolenic). After analysis of variance (ANOVA), we calculated the saturated fatty acid (SFA) amount, monounsaturated fatty acid (MUFA) and polyunsaturated fatty acid (PUFA) ratio (MUFA:PUFA) as an indicator of the oxidative stability of the oil, and linoleic and linolenic acids ratio as an indicator of nutritional quality. To give further insight into divergence of given set of genotypes, cluster analysis was performed, while correlation analysis was used to better understand the relationships between all the traits investigated in this research, which play an important role in breeding procedures. The experimental and biometric results indicate the existence of variability in phenotypic expression of investigated traits with significant year and genotype effects, while cluster analysis divided genotypes into two main groups confirming the results of ANOVA. The amount of oil was higher than that obtained in earlier researches conducted in the same geographical region and all averages of five fatty acids coincided with the average values for commercial soybean varieties. MUFA:PUFA was lower than recommended for all tested genotypes, and linoleic and linolenic acids ratio values were higher than the recommended limits for vegetable oils. The results of the correlation study showed the significant and positive relationship between oil and oleic acid, while the significant and negative correlation between oil and both polyunsaturated fatty acids. According to the overall conclusions, the most suitable as a parental component in breeding programs aimed at creating genotypes for the production of edible oil was genotype OS-L-774, while genotypes OS-L-806 and OS-L-805 were the least suitable for the same purpose.

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Section: Introductionmentioning

confidence: 99%

Screening of early maturing soybean genotypes for production of high quality edible oil

Kočar

Sudarić

Sudar

et al. 2018

Zemdirbyste-Agriculture

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“…Epidemiologic studies have generated conflicting results. Some studies show that a high dietary intake of w-3 fatty acids may reduce the risk of prostate cancer (7)(8)(9)(10)(11), whereas others have seen either no association (12)(13)(14), or an increased risk of prostate cancer in people with a high intake of w-3 fatty acids (15,16). Moreover epidemiologic data suggest that fish or marine-derived w-3 fatty acids may have a more pronounced effect on biologically aggressive tumors or on their progression, and a less pronounced effect on initiation of more benign or earlier-stage tumors often detected by screening (4).…”

Section: Introductionmentioning

confidence: 99%

Prostatic and Dietary Omega-3 Fatty Acids and Prostate Cancer Progression during Active Surveillance

Moreel

Allaire

Léger

et al. 2014

Cancer Prevention Research

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The association between omega-3 (w-3) fatty acids and prostate cancer has been widely studied. However, little is known about the impact of prostate tissue fatty acid content on prostate cancer progression. We hypothesized that compared with the estimated dietary w-3 fatty acids intake and the w-3 fatty acids levels measured in red blood cells (RBC), the prostate tissue w-3 fatty acid content is more strongly related to prostate cancer progression. We present the initial observations from baseline data of a phase II clinical trial conducted in a cohort of 48 untreated men affected with low-risk prostate cancer, managed under active surveillance. These men underwent a first repeat biopsy session within 6 months after the initial diagnosis of low-risk prostate cancer, at which time 29% of the men had progressed from a Gleason score of 6 to a Gleason score of 7. At the first repeat biopsy session, fatty acid levels were assessed with a food-frequency questionnaire, and determined in the RBC and in the prostate tissue biopsy. We found that eicosapentaenoic acid (EPA) was associated with a reduced risk of prostate cancer progression when measured directly in the prostate tissue. Thus, this initial interim study analysis suggests that prostate tissue w-3 fatty acids, especially EPA, may be protective against prostate cancer progression in men with low-risk prostate cancer. Cancer Prev Res; 7(7); 766-76. Ó2014 AACR.

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“…In addition, compared to flaxseed and perilla oils, P. volubilis seed oil have high α-linolenic acid content, which is converted to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in living organisms (Kayama, 1995;Wada, 2008). The oil is thought to have anti-inflammatory properties and offers protection against blood clots, coronary heart disease and high blood pressure (Sawai, 2009;Williams, 2011;Okuyama, 2001;Ogawa et al, 2009;Albelt et al, 2005;Hu et al, 1999). Individuals who either cannot or do not eat fish on a daily basis, or who only eat fish infrequently, can supplement their n-3 fatty acid intake with flaxseed oil or perilla oil (Editorial Department, 2005, i).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Properties of Plukenetia volubilis L. Seeds and Oxidative Stability of Cold-pressed Oil (Green Nut Oil)

Takeyama

Fukushima

2013

FSTR

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Cold-pressed oil from the seeds of Plukenetia volubilis L. (green nut oil, GNO) has been shown to be rich in n-3 fatty acid content, similar to flaxseed and perilla oils. These fatty acids are readily oxidized at high temperatures and under UV irradiation, limiting their potential applications. We therefore set out to clarify the physicochemical properties of green nuts. In addition, to explore means of the degradation process, we investigated the oxidation characteristics of GNO and the effects of oxidation on fatty acids. Results showed that GNO was stable up to 140℃ and exhibited greater UV resistance than the other oils. This may be related to the 10% lower α-linolenic acid content of GNO, compared to the other oils, as well as the presence of γ-and δ-tocopherols. GNO was capable of tolerating a certain degree of heat processing.

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A high ratio of dietary n-6/n-3 polyunsaturated fatty acids is associated with increased risk of prostate cancer

Cited by 160 publications

References 38 publications

Screening of early maturing soybean genotypes for production of high quality edible oil

Screening of early maturing soybean genotypes for production of high quality edible oil

Prostatic and Dietary Omega-3 Fatty Acids and Prostate Cancer Progression during Active Surveillance

Physicochemical Properties of Plukenetia volubilis L. Seeds and Oxidative Stability of Cold-pressed Oil (Green Nut Oil)

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