A High-Sensitive Fiber Specklegram Refractive Index Sensor With Microfiber Adjustable Sensing Area

Zain, Mostafa AL; Karimi–Alavijeh, Hamidreza; Moallem, Payman; Khorsandi, Alireza; Ahmadi, Keyvan

doi:10.1109/jsen.2023.3278608

Cited by 10 publications

(3 citation statements)

References 23 publications

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“…By subtracting the local mean, the ZNCC algorithm compensates for the brightness changes of the obtained pattern, making it more robust to linear and uniform brightness conversions. The specific expression is [25]…”

Section: Working Principle and Experimental Setupmentioning

confidence: 99%

A Multimode Microfiber Specklegram Biosensor for Measurement of CEACAM5 through AI Diagnosis

Liu,

Lin,

Zhao

et al. 2024

Biosensors

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Carcinoembryonic antigen (CEACAM5), as a broad-spectrum tumor biomarker, plays a crucial role in analyzing the therapeutic efficacy and progression of cancer. Herein, we propose a novel biosensor based on specklegrams of tapered multimode fiber (MMF) and two-dimensional convolutional neural networks (2D-CNNs) for the detection of CEACAM5. The microfiber is modified with CEA antibodies to specifically recognize antigens. The biosensor utilizes the interference effect of tapered MMF to generate highly sensitive specklegrams in response to different CEACAM5 concentrations. A zero mean normalized cross-correlation (ZNCC) function is explored to calculate the image matching degree of the specklegrams. Profiting from the extremely high detection limit of the speckle sensor, variations in the specklegrams of antibody concentrations from 1 to 1000 ng/mL are measured in the experiment. The surface sensitivity of the biosensor is 0.0012 (ng/mL)−1 within a range of 1 to 50 ng/mL. Moreover, a 2D-CNN was introduced to solve the problem of nonlinear detection surface sensitivity variation in a large dynamic range, and in the search for image features to improve evaluation accuracy, achieving more accurate CEACAM5 monitoring, with a maximum detection error of 0.358%. The proposed fiber specklegram biosensing scheme is easy to implement and has great potential in analyzing the postoperative condition of patients.

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Section: Working Principle and Experimental Setupmentioning

confidence: 99%

A Multimode Microfiber Specklegram Biosensor for Measurement of CEACAM5 through AI Diagnosis

Liu,

Lin,

Zhao

et al. 2024

Biosensors

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“…In recent years, significant attention has been paid to specklegram chemical-and biosensors involving various specialty fibers or standard fiber pre-processing, allowing light interaction with surrounding media. The applications of chemical sensors include salinity sensors [125,126], refractive index sensors [103,[127][128][129][130][131][132], biosensors [133], and even DNA-related sensors [134].…”

Section: Group A-physical Group B-mentioning

confidence: 99%

Advances in Optical Fiber Speckle Sensing: A Comprehensive Review

Chapalo,

Stylianou,

Mégret

et al. 2024

Photonics

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Optical fiber sensors have been studied, developed, and already used in the industry for more than 50 years due to their multiplexing capabilities, lightweight design, compact form factors, and electromagnetic field immunity. The scientific community continuously studies new materials, schemes, and architectures aiming to improve existing technologies. Navigating through diverse sensor technologies, including interferometry, intensity variation, nonlinear effects, and grating-based sensors, fiber specklegram sensors (FSSs) emerge as promising alternatives due to their simplicity and low cost. This review paper, emphasizing the potential of FSSs, contributes insights to the present state and future prospects for FSSs, providing a holistic view of advancements propelling FSSs to new frontiers of innovation. Subsequent sections explore recent research, technological trends, and emerging applications, contributing to a deeper understanding of the intricacies shaping the future of FFS sensor technologies.

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“…There is high demand for such sensors in the biological, chemical, environmental, defense, transport, and food industries, both for the detection of specific targets and also in the area of process control. − Refractive index sensors typically employ the overlap of the evanescent tail of a guided mode with the analyte to detect small changes, either with or without a binder molecule attached to the surface for increased specificity. , The implementation of such sensors in a real industrial environment is limited, however, by their sensitivity to other external influences such as mechanical vibrations and temperature variations; these external influences generate significant noise, which may easily screen the desired signal(s). For example, mechanical vibrations often limit the use of sensors to vibration-free environments, − which are impractical for applications in the field such as in industrial plants. Some sensor architectures such as photonic crystal fiber grating refractive index sensors achieve very high refractive index sensitivity, in the 1 × 10 –6 range, and mechanical tolerance, but they are not temperature compensated and require the analyte to be infiltrated into the fiber as well as a high performance spectrometer for the readout, which limits these sensors to laboratory research.…”

mentioning

confidence: 99%

Noise Tolerant Photonic Bowtie Grating Environmental Sensor

Li,

Suliali,

Sahoo

et al. 2024

ACS Sens.

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Resonant photonic refractive index sensors have made major advances based on their high sensitivity and contact-less readout capability, which is advantageous in many areas of science and technology. A major issue for the technological implementation of such sensors is their response to external influences, such as vibrations and temperature variations; the more sensitive a sensor, the more susceptible it also becomes to external influences. Here, we introduce a novel bowtieshaped sensor that is highly responsive to refractive index variations while compensating for temperature changes and mechanical (linear and angular) vibrations. We exemplify its capability by demonstrating the detection of salinity to a precision of 0.1%, corresponding to 2.3 × 10 −4 refractive index units in the presence of temperature fluctuations and mechanical vibrations. As a second exemplar, we detected bacteria growth in a pilot industrial environment. Our results demonstrate that it is possible to translate high sensitivity resonant photonic refractive index sensors into real-world environments.

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A High-Sensitive Fiber Specklegram Refractive Index Sensor With Microfiber Adjustable Sensing Area

Cited by 10 publications

References 23 publications

A Multimode Microfiber Specklegram Biosensor for Measurement of CEACAM5 through AI Diagnosis

A Multimode Microfiber Specklegram Biosensor for Measurement of CEACAM5 through AI Diagnosis

Advances in Optical Fiber Speckle Sensing: A Comprehensive Review

Noise Tolerant Photonic Bowtie Grating Environmental Sensor

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