A High-Sensitivity Benchtop X-Ray Fluorescence Emission Tomography (XFET) System With a Full-Ring of X-Ray Imaging-Spectrometers and a Compound-Eye Collimation Aperture

Mandot, Shubham; Zannoni, Elena M.; Cai, Ling; Nie, Xingchen; Rivière, Patrick J. La; Wilson, Matthew D.; Meng, Ling Jian

doi:10.1109/tmi.2023.3348791

Cited by 3 publications

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

High-sensitivity and spatial resolution benchtop cone beam XFCT imaging system with pixelated photon counting detectors using enhanced multipixel events correction method

Pu,

Song,

et al. 2024

Phys. Med. Biol.

View full text Add to dashboard Cite

Objective. High atomic number element nanoparticles have shown potential in tumor diagnosis and therapy. X-ray fluorescence computed tomography (XFCT) technology enables quantitative imaging of high atomic number elements by specifically detecting characteristic X-ray signals. The potential for further biomedical applications of XFCT depends on balancing sensitivity, spatial resolution, and imaging speed in existing XFCT imaging systems. Approach. In this study, we utilized a high-energy resolution pixelated photon-counting detector for XFCT imaging. We tackled degradation caused by multi-pixel events in the photon-counting detector through energy and interaction position corrections. Sensitivity and spatial resolution imaging experiments were conducted using PMMA phantoms to validate the effectiveness of the multi-pixel events correction algorithm. Main results. After correction, the system's sensitivity and spatial resolution have both improved. Furthermore, XFCT/CBCT dual-modality imaging of gadolinium nanoparticles within mice subcutaneous tumor was successfully achieved. Significance. These results demonstrate the preclinical research application potential of the XFCT/CBCT dual-modality imaging system in high atomic number nanoparticle-based tumor diagnosis and therapy.

show abstract

High-sensitivity and spatial resolution benchtop cone beam XFCT imaging system with pixelated photon counting detectors using enhanced multipixel events correction method

Pu,

Song,

et al. 2024

Phys. Med. Biol.

View full text Add to dashboard Cite

show abstract

Full-field multimodal imaging technology of x-ray transmission, fluorescence, and scattering tomography (PI-CT) with polychromatic source

Li,

Song,

2024

Developments in X-Ray Tomography XV

View full text Add to dashboard Cite

This paper introduces and discusses the development of an interesting multimodal CT imaging technique, called full Xray particle information CT (PI-CT), which combines X-ray transmission, fluorescence, and scattering tomography using a polychromatic X-ray source. The PI-CT allows for the simultaneous reconstruction of high-resolution tissue structure images, quantitative imaging of high-Z element concentrations, and electron density distributions. During X-ray photons passing through an object, photoelectric effects and Compton scattering may occur, resulting in X-ray attenuation and the generation of scattering and fluorescent photons. All these interaction information is innovatively utilized in PI-CT to detect and image different physical quantities inside the object. X-ray transmission CT could image the object's highresolution structure. X-ray fluorescence CT could realize the quantitative imaging of high-Z agents. Compton scattering CT could reconstruct the electron density information, which may have better contrast in weak absorption radiation imaging cases, such as lung imaging. Therefore, with the help of functional imaging nanoparticles, PI-CT can provide both high-resolution tissue structure images and highly sensitive molecular functional images of living animals, which provides a new multimodal tool for tumor diagnosis and treatment. Experimental results demonstrate the potential of PI-CT in enhancing multimodal CT imaging, particularly in tumor diagnosis and treatment applications.

show abstract

A study on position and energy correction of multi-pixel events in pixelated semiconductor detector for XFCT imaging

Pu,

Song,

2024

Developments in X-Ray Tomography XV

View full text Add to dashboard Cite

X-ray fluorescence computed tomography (XFCT) is an emerging imaging modality that enables quantification of the distribution of high-Z elements, including gold, gadolinium, and iodine, in diverse biomedical applications, by specifically detecting the X-ray fluorescence (XRF) emitted from the target element. Pixelated semiconductor detectors such as Cadmium Telluride (CdTe) and Cadmium Zinc Telluride (CZT) sensors are particularly suited for XFCT imaging due to their high energy and spatial resolution capabilities. However, their performance degrades because of multi-pixel events, which occur when an incident photon deposits energy across multiple adjacent pixels. In this study, we implement corrections for the energy loss during charge sharing. Furthermore, for bi-pixel events occurring within the gadolinium K α energy and caused by the escape and re-capture of detector elements' x-ray fluorescence, we correct the interaction location. To validate the efficacy of the charge sharing energy loss correction and fluorescence escape events location correction, we utilized a PMMA phantom filled with Gadolinium saline solutions at concentrations ranging from 0 to 1.2mg/ml for XFCT imaging. The implemented corrections enhanced the contrast noise ratio in the gadolinium region. These improvements in XFCT imaging quality are useful for the preclinical investigation of precise tumor diagnosis and treatment using high atomic number element nanoparticles, and for other semiconductor detector-based imaging modalities.

show abstract

A High-Sensitivity Benchtop X-Ray Fluorescence Emission Tomography (XFET) System With a Full-Ring of X-Ray Imaging-Spectrometers and a Compound-Eye Collimation Aperture

Cited by 3 publications

References 67 publications

High-sensitivity and spatial resolution benchtop cone beam XFCT imaging system with pixelated photon counting detectors using enhanced multipixel events correction method

High-sensitivity and spatial resolution benchtop cone beam XFCT imaging system with pixelated photon counting detectors using enhanced multipixel events correction method

Full-field multimodal imaging technology of x-ray transmission, fluorescence, and scattering tomography (PI-CT) with polychromatic source

A study on position and energy correction of multi-pixel events in pixelated semiconductor detector for XFCT imaging

Contact Info

Product

Resources

About