2022
DOI: 10.3389/fnut.2022.801667
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A High Serum Phosphate and Calcium-Phosphate Product Is Associated With Cerebral Small Vascular Disease in Patients With Stroke: A Real-World Study

Abstract: Cerebral small vessel disease (CSVD) is a slowly progressive disease, often accompanied by stroke, and results in dementia, depression, and cognitive impairment. It was already known that calcium and phosphorus metabolism (CPM) disorders were associated with vascular-related adverse events. The risk factors of CSVD and the relationship between serum calcium (Ca), phosphorus (P), calcium-phosphate product (Ca × P), and CSVD in patients with stroke without CPM disorders are still obscure. In our study, 528 patie… Show more

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Cited by 3 publications
(2 citation statements)
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“…Subclinical atherosclerosis is associated with impaired cognitive function and atherosclerotic events with significant cognitive impairment [18]. Lastly, a current report that showed that high serum P and calciumphosphate product are potential risk factors for cerebral small vessel disease of all subtypes, including lacunes, white matter hyperintensities, and cerebral microbleeds [19].…”
Section: Epidemiology and Etiopathogenesis Of Cognitive Impairment In...mentioning
confidence: 84%
“…Subclinical atherosclerosis is associated with impaired cognitive function and atherosclerotic events with significant cognitive impairment [18]. Lastly, a current report that showed that high serum P and calciumphosphate product are potential risk factors for cerebral small vessel disease of all subtypes, including lacunes, white matter hyperintensities, and cerebral microbleeds [19].…”
Section: Epidemiology and Etiopathogenesis Of Cognitive Impairment In...mentioning
confidence: 84%
“…The disorder of calcium and phosphorus metabolism may give rise to vascular calcification and endothelial dysfunction, which in turn lead to an increase in the incidence of cerebrovascular diseases and related cognitive impairment [55,56]. The disorder of calcium and phosphorus metabolism is also related to cerebral small vessel disease, which is a risk factor for cerebral small vessel disease stroke and causes cognitive impairment by cerebral small vessel disease [57]. Higher FGF23 levels are associated with a higher risk of dementia [58].…”
Section: Calcium and Phosphorus Metabolism Disorder And Secondary Hyp...mentioning
confidence: 99%