A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model

Liu, Zheying; Li, Shih-Kuan; Huang, Chih-Kang; Huang, Ching-Feng

doi:10.3390/nu13113684

Cited by 7 publications

(4 citation statements)

References 34 publications

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“…These effects were dependent on NFAT5 and SGK1. 65 Consistently, an HSD augmented Th2 responses in food allergy mice, 136 while the high-salt formulation of Al(OH) 3 enhanced the ovalbumin (OVA)induced Th2 response in mice. 109 In addition, high NaCl can significantly increase the polarization of human Tfh cells.…”

Section: Other T Helper Cellsmentioning

confidence: 90%

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The modulatory effect of high salt on immune cells and related diseases

Alu

Wei

et al. 2022

Cell Proliferation

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Background: The adverse effect of excessive salt intake has been recognized in decades. Researchers have mainly focused on the association between salt intake and hypertension. However, studies in recent years have proposed the existence of extra-renal sodium storage and provided insight into the immunomodulatory function of sodium.Objectives: In this review, we discuss the modulatory effects of high salt on various innate and adaptive immune cells and immune-regulated diseases. Methods: We identified papers through electronic searches of PubMed database from inception to March 2022. Results: An increasing body of evidence has demonstrated that high salt can modulate the differentiation, activation and function of multiple immune cells. Furthermore, a high-salt diet can increase tissue sodium concentrations and influence the immune responses in microenvironments, thereby affecting the development of immune-regulated diseases, including hypertension, multiple sclerosis, cancer and infections. These findings provide a novel mechanism for the pathology of certain diseases and indicate that salt might serve as a target or potential therapeutic agent in different disease contexts. Conclusion: High salt has a profound impact on the differentiation, activation and function of multiple immune cells. Additionally, an HSD can modulate the development of various immune-regulated diseases. | INTRODUCTIONSalt (NaCl), common in our daily life, can be found naturally in various foods and is used in food manufacturing, the chemical industry, clinical therapy and so forth. For instance, salty condiments contain plenty of NaCl, whereas saline is the most frequently administered intravenous fluid. 1 Although salt is necessary for the human body, excessive salt intake can be detrimental and increase the risk of diseases such as hypertension, heart failure and renal disease. 2 In addition, the immunomodulatory function of salt has been reported. Early studies found that high salt increased the cytokine production in peripheral blood mononuclear cells (PBMCs). 3,4 In the past decades, growing evidence has indicated that high salt can influence various immune cells. Moreover, a high-salt diet (HSD) has a pronounced effect on immuneregulated diseases, and salt is potentially applied in immune therapy. This review will summarize some of the recent advances in the

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Section: Other T Helper Cellsmentioning

confidence: 90%

“…These responses were associated with Th17 cell activation in the kidney. 163,164 Moreover, an HSD might exacerbate food allergy in mice, 136 while sodium may participate in the progression of atopic dermatitis by regulating Th2 responses. 65…”

Section: Othersmentioning

confidence: 99%

The modulatory effect of high salt on immune cells and related diseases

Alu

Wei

et al. 2022

Cell Proliferation

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“…Studies found that inhibiting the entry of Ca 2+ through calcium channels can stabilize mast cells, to play a protective role against ovalbumin (OVA)-sensitized food allergies . In the mouse model of food allergies, excessive intake of Na + can promote Th2 response . Selenium-enriched foods have gained popularity in recent years, and selenium has also been shown to be involved in multiple processes of food allergies, including maintenance of immune homeostasis, prevention of free radical damage, and modulation of the gut microbiota, all of which may help prevent and treat food allergies .…”

Section: Direct Intervention and Modulation Of Food Allergies By Matr...mentioning

confidence: 99%

“…30 In the mouse model of food allergies, excessive intake of Na + can promote Th2 response. 31 Selenium-enriched foods have gained popularity in recent years, and selenium has also been shown to be involved in multiple processes of food allergies, including maintenance of immune homeostasis, prevention of free radical damage, and modulation of the gut microbiota, all of which may help prevent and treat food allergies. 32 It is not hard to see from these studies that the effects of the large family of minerals that are members of food allergies cannot be overstated.…”

Section: As Antigens or Immunomodulatorymentioning

confidence: 99%

New Perspectives on Food Matrix Modulation of Food Allergies: Immunomodulation and Component Interactions

Wu,

Chen,

et al. 2023

J. Agric. Food Chem.

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Oleuropein Prevents OVA‐Induced Food Allergy in Mice by Enhancing the Intestinal Epithelial Barrier and Remodeling the Intestinal Flora

Guo

et al. 2022

Molecular Nutrition Food Res

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Scope This study assesses whether oleuropein prevents ovalbumin (OVA)‐induced food allergy (FA) and investigates the underlying mechanisms. Methods and results A Balb/c FA mouse model is established and maintained for 7 weeks. The subjects are administered OVA by oral gavage to induce FA and supplemented with different oleuropein doses (1.00–20.00 mg kg−1 per day) to evaluate its preventative efficacy. The results indicate that oleuropein effectively alleviates OVA‐induced allergy symptoms and promotes temperature elevation in sensitized mice. The secretion of serology‐specific OVA‐immunoglobulin (Ig)E, OVA‐IgG, and histamine is inhibited in the sensitized mice. Oleuropein dramatically upregulates the expression of intestinal tight junction (TJ) proteins, regenerating gene (Reg) IIIγ, and interleukin (IL)‐22, enhancing the physical and biochemical barrier function of the intestinal epithelium. Additionally, oleuropein improves the immune homeostasis of the intestinal epithelium by affecting the function of mucosal mast cells and regulatory T (Treg) cells. The disordered intestinal flora of the sensitized mice also improves after oleuropein administration. Conclusions These findings suggest that oleuropein prevents FA by enhancing intestinal epithelial barrier function and improving immune homeostasis and intestinal flora in sensitized mice. Therefore, diets rich in oleuropein should be recommended for people with FA.

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A High-Sodium Diet Modulates the Immune Response of Food Allergy in a Murine Model

Cited by 7 publications

References 34 publications

The modulatory effect of high salt on immune cells and related diseases

The modulatory effect of high salt on immune cells and related diseases

New Perspectives on Food Matrix Modulation of Food Allergies: Immunomodulation and Component Interactions

Oleuropein Prevents OVA‐Induced Food Allergy in Mice by Enhancing the Intestinal Epithelial Barrier and Remodeling the Intestinal Flora

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