Mediterranean regions are prone to heavy rainfall, flash floods, and erosion issues. Drop size distribution (DSD) is a key element for studying these phenomena through the hydrological variables which can be derived from it (rainfall rates and totals, kinetic energy fluxes). This paper proposes a five-year (2012-2016) DSD climatology, summarized by scaling parameters for concentration, size, and shape. The DSD network is composed of two longitudinal transects of three OTT Parsivel optical disdrometers each, across the Mediterranean Cevennes-Vivarais region. The influence of several factors are analysed: location (distance from the sea, orographic environment), season, daily synoptic weather situation (derived from geopotential heights, at 700 and 1000 hPa), rainfall type (analysed from 5 min radar data), as well as some combinations of these factors. It was found and/or confirmed that the orographic environment, season, weather patterns associated with the exposure to low level atmospheric flows, and rainfall types influenced the microphysical processes, leading to rainfall, measured at the ground. Consequently, the DSD characteristics, as well as the relationships between the rainfall rate and reflectivity factor, are influenced by these factors.