A high-sugar diet affects cellular and humoral immune responses in Drosophila

Yu, Shichao; Zhang, Gaoqun; Jin, Li

doi:10.1016/j.yexcr.2018.04.032

Cited by 32 publications

(23 citation statements)

References 44 publications

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“…It is known that larvae fed on a high-sucrose diet develop as smaller adults ( 21 ). High sugar stress also corresponds with a reduction in immune cell numbers ( 44 ). The sugar stress–induced growth defect is a consequence of reduction in fat body insulin signaling ( 39 , 45 ).…”

Section: Resultsmentioning

confidence: 99%

Immune Control of Animal Growth in Homeostasis and Nutritional Stress in Drosophila

et al. 2020

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A large body of research implicates the brain and fat body (liver equivalent) as central players in coordinating growth and nutritional homeostasis in multicellular animals. In this regard, an underlying connection between immune cells and growth is also evident, although mechanistic understanding of this cross-talk is scarce. Here, we explore the importance of innate immune cells in animal growth during homeostasis and in conditions of nutrient stress. We report that Drosophila larvae lacking blood cells eclose as small adults and show signs of insulin insensitivity. Moreover, when exposed to dietary stress of a high-sucrose diet (HSD), these animals are further growth retarded than normally seen in regular animals raised on HSD. In contrast, larvae carrying increased number of activated macrophage-like plasmatocytes show no defects in adult growth when raised on HSD and grow to sizes almost comparable with that seen with regular diet. These observations imply a central role for immune cell activity in growth control. Mechanistically, our findings reveal a surprising influence of immune cells on balancing fat body inflammation and insulin signaling under conditions of homeostasis and nutrient overload as a means to coordinate systemic metabolism and adult growth. This work integrates both the cellular and humoral arm of the innate immune system in organismal growth homeostasis, the implications of which may be broadly conserved across mammalian systems as well.

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Section: Resultsmentioning

confidence: 99%

Immune Control of Animal Growth in Homeostasis and Nutritional Stress in Drosophila

et al. 2020

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“…The larvae respond to a lack of nutrients by activating the Toll pathway within hemocytes in circulation and in the lymph gland, in a manner reminiscent of the stress response induced when a larva is challenged with wasp parasitization (Shim et al 2012; Louradour et al 2017). A high-sugar diet in larvae induces lamellocytes via JNK, and also decreases phagocytosis of large particles such as fungal spores and latex beads (Yu et al 2018). In adult flies, a high-fat diet causes global activation of the JAK/STAT pathway and the adult circulating cells secrete Upd3, which triggers a systemic immune response (Woodcock et al 2015).…”

Section: Nutritional and Sensory Control Of Hematopoiesismentioning

confidence: 99%

Drosophilaas a Genetic Model for Hematopoiesis

et al. 2019

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In this FlyBook chapter, we present a survey of the current literature on the development of the hematopoietic system in Drosophila. The Drosophila blood system consists entirely of cells that function in innate immunity, tissue integrity, wound healing, and various forms of stress response, and are therefore functionally similar to myeloid cells in mammals. The primary cell types are specialized for phagocytic, melanization, and encapsulation functions. As in mammalian systems, multiple sites of hematopoiesis are evident in Drosophila and the mechanisms involved in this process employ many of the same molecular strategies that exemplify blood development in humans. Drosophila blood progenitors respond to internal and external stress by coopting developmental pathways that involve both local and systemic signals. An important goal of these Drosophila studies is to develop the tools and mechanisms critical to further our understanding of human hematopoiesis during homeostasis and dysfunction.

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“…Sugar limitation is a vital part of an immune-boosting diet, as a high-sugar diet (HSD) induces type 2 diabetes (T2D) and obesity, also HSD induced the aberrant activation of the innate immune system, including inflammation, so patients should strive to limit the sugar intake to less than 5% of the daily calories [126]. Patients must stay hydrated as dehydration can lead to complications that can elevate susceptibility to the illness.…”

Section: Resultsmentioning

confidence: 99%

The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients

Megahed

Zhou

Sun

et al. 2021

Egypt Liver Journal

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Background Non-alcoholic fatty liver disease (NAFLD) is the most epidemic liver disorder worldwide as a result of rapid lifestyle transformation over the past few decades and is expected to elevate in the next few years as well as it is ranging from plain hepatic steatosis via non-alcoholic steatohepatitis (NASH) to liver cirrhosis and hepatocellular carcinoma (HCC). Main text NAFLD can also stimulate the diseases progression as diabetes and cardiovascular. Therefore, understanding the NAFLD pathogenesis is of vital clinical interest additionally is a crucial for disease treatment and prevention. After analyzing NAFLD and liver diseases prevalence, it has been a belief regarding the interaction between NAFLD and chronic hepatitis B (CHB). Conclusion The liver is an essential innate immune organ with large numbers of innate immune cells that contribute in NAFLD pathogenesis, additionally play the influential role that control NAFLD progression in the hepatitis B patients. Here, we summarized the recent advances in understanding and managing the NAFLD patients with chronic hepatitis B infection and interplay with innate immunity.

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A high-sugar diet affects cellular and humoral immune responses in Drosophila

Cited by 32 publications

References 44 publications

Immune Control of Animal Growth in Homeostasis and Nutritional Stress in Drosophila

Immune Control of Animal Growth in Homeostasis and Nutritional Stress in Drosophila

Drosophilaas a Genetic Model for Hematopoiesis

The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients

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