A high throughput method for screening deep-seeding tolerance in sorghum

Zou, Guihua; Zhou, Lengbo; Zhai, Guowei; Ding, Yanqing; Lü, Ping; Liu, Heqin; Zhen, Xueqiang; Liu, Xiuhui; Zhang, Liyi; Xin, Zhanguo; Chen, Heyun

doi:10.1007/s10722-019-00835-0

Cited by 1 publication

(2 citation statements)

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“…Natarajan Arul Murugan [17] developed a method to directly screen enzyme reaction products from cells without needing purification or modification, greatly shortening screening times and yielding improved enzymatic catalysts.…”

Section: Directed Evolution Screening Technologymentioning

confidence: 99%

“…Niklas M [19] proposed using non-precise quantum computation methods to obtain molecular structures, followed by data augmentation to improve predictivity, providing possibilities for practical applications. Additionally, the cell deformation-based screening chip developed by Ali Raza [20] offered a new approach for rapid discrimination of cell states. With technological advances, highthroughput screening platforms are progressing towards more accurate and information-rich directions.…”

Section: Fluorescence Technology Applicationsmentioning

confidence: 99%

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High-throughput screening technologies for drug discovery

Wang

2023

TNS

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The development of high-throughput screening technologies has revolutionized the field of drug discovery by significantly improving the efficiency of compound library screening. Traditional screening methods, such as manual screening and biochemical assays, were time-consuming and limited in their ability to identify lead compounds. However, the advent of high-throughput screening technologies has overcome these limitations and provided researchers with a more efficient and effective approach. This review begins by examining the background, characteristics, and limitations of conventional screening methods. These methods often required large amounts of time, resources, and labor, making them impractical for large-scale compound screening. In recent years, some new technologies have emerged, including virtual screening, image analysis, prediction methods, and microarray-based screening. Each of these approaches has its own strengths and limitations, but collectively they have greatly enhanced the efficiency and accuracy of compound identification. These viewpoints highlight the successful application of these technologies in identifying lead compounds for various therapeutic targets. Finally, the review envisions the future development of high-throughput screening technologies. It emphasizes the need for continuous optimization and innovation to further improve the efficiency and effectiveness of compound identification. The ultimate goal is to shorten drug development timelines and provide high-quality lead compounds for the benefit of patients. In conclusion, the emergence of high-throughput screening technologies has significantly improved the efficiency of compound library screening and provided better lead compounds for drug discovery. Ongoing advancements in these technologies hold great promise for the future of pharmaceutical research and development.

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Section: Directed Evolution Screening Technologymentioning

confidence: 99%

Section: Fluorescence Technology Applicationsmentioning

confidence: 99%