2019
DOI: 10.1039/c8lc01262h
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A high-throughput microfluidic microphysiological system (PREDICT-96) to recapitulate hepatocyte function in dynamic, re-circulating flow conditions

Abstract: Microphysiological systems (MPSs) are dynamic cell culture platforms that incorporate mechanical and chemical cues to recapitulate organ‐specific functions and architecture. Recent advances in microfabrication technologies and processes have enabled the development of enhanced in vitro models that capture human physiology more accurately while increasing throughput and reducing material‐based technical artifacts. A common candidate for MPS development is liver due to its crucial role in drug metabolism, inflam… Show more

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Cited by 67 publications
(67 citation statements)
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“…The PREDICT96 organ-on-chip platform consists of a microfluidic culture plate with 96 individual devices and a perfusion system driven by 192 microfluidic pumps integrated into the plate lid [25,26]. Here the platform is adapted to support culture of barrier tissues, such as airway tissues, by establishment and maintenance of an ALI.…”
Section: Microfluidic Platformmentioning
confidence: 99%
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“…The PREDICT96 organ-on-chip platform consists of a microfluidic culture plate with 96 individual devices and a perfusion system driven by 192 microfluidic pumps integrated into the plate lid [25,26]. Here the platform is adapted to support culture of barrier tissues, such as airway tissues, by establishment and maintenance of an ALI.…”
Section: Microfluidic Platformmentioning
confidence: 99%
“…The microfluidic stack is attached to a modified 384well COP plate (Aurora Microplates, Whitefish, MT, USA) using a 0.135 mm thick pressure sensitive adhesive consisting of a 25.4 µm polyester carrier film with MA-69 acrylic medical grade adhesive ARcare® 90106 (Adhesives Research, Inc., Glen Rock, PA, USA), which had been previously laser-cut in the pattern of the well plate grid and laminated with a hydraulic press at 1.0 MPa for 2 min. Further details on the fabrication process are found elsewhere [25,26].…”
Section: Microfluidic Platformmentioning
confidence: 99%
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