A High-throughput Microfluidic Rare Cell Enrichment System Based on Dielectrophoresis and Filtering

Özkayar, Gürhan; Yalçın, Yağmur Demircan; Özgür, Ebru; Gündüz, Ufuk; Külah, Haluk

doi:10.1016/j.protcy.2017.04.076

Cited by 2 publications

(1 citation statement)

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“…The proof-of-concept of the presented technique and implemented device was shown by conducting experiments using both beads with different sizes (1 µm and 10 µm) and K562 leukemia cells. In a later study, Özkayar integrated DEP and size-based filtration techniques into a single MEMS-enabled microfluidic chip to realize the enrichment of CTCs from blood with high throughput [225]. Hydrodynamic and pDEP forces were used to control the motion of cells over the planar electrodes used to create non-uniform electric field.…”

Section: Separation Of Cellsmentioning

confidence: 99%

A Prominent Cell Manipulation Technique in BioMEMS: Dielectrophoresis

2020

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BioMEMS, the biological and biomedical applications of micro-electro-mechanical systems (MEMS), has attracted considerable attention in recent years and has found widespread applications in disease detection, advanced diagnosis, therapy, drug delivery, implantable devices, and tissue engineering. One of the most essential and leading goals of the BioMEMS and biosensor technologies is to develop point-of-care (POC) testing systems to perform rapid prognostic or diagnostic tests at a patient site with high accuracy. Manipulation of particles in the analyte of interest is a vital task for POC and biosensor platforms. Dielectrophoresis (DEP), the induced movement of particles in a non-uniform electrical field due to polarization effects, is an accurate, fast, low-cost, and marker-free manipulation technique. It has been indicated as a promising method to characterize, isolate, transport, and trap various particles. The aim of this review is to provide fundamental theory and principles of DEP technique, to explain its importance for the BioMEMS and biosensor fields with detailed references to readers, and to identify and exemplify the application areas in biosensors and POC devices. Finally, the challenges faced in DEP-based systems and the future prospects are discussed.

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Section: Separation Of Cellsmentioning

confidence: 99%