A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells

Akao, Yukihiro; Seki, Norio; Nakagawa, Yoshihito; Yi, Hong; Matsumoto, Kenji; Ito, Yukie; Ito, Kuniyasu; Funaoka, Masamitsu; Maruyama, Wakako; Naoi, Makoto; Nozawa, Yoshinori

doi:10.1016/j.bmc.2004.07.022

Cited by 62 publications

(39 citation statements)

References 27 publications

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“…The yield of lignopyrogallol was much lower than others. This is based on better solubility in ether and aqueous solution, contributing to more phenolic hydroxyl groups (Akao et al 2004). Therefore, the color of ether was darkest from the process of refining lignopyrogallol.…”

Section: Yield Of Lignophenolsmentioning

confidence: 99%

Preparation and Characterization of Polyhydroxybutyrate-Bamboo Lignophenol Biocomposite Films

Qian

Dai

et al. 2015

BioResources

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Four kinds of lignophenols (Lps) were derived from native bamboo (Sinocalamus affinis) lignin through phase separation system by using four kinds of phenols (p-cresol, catechol, resorcinol and pyrogallol) as derivatives and 72% concentrated sulfuric acid as catalyst. The resulting lignophenols were characterized by 1 H-NMR, FT-IR, and GPC analysis. Then they were blended with polyhydroxybutyrate (PHB) to cast thin biocomposite films. The mechanical properties, water-absorbing qualities, and thermal properties of films were tested and discussed. The results indicated that phase separation treatment can effectively improve phenolic hydroxyl contents of lignins. The lignin macromolecule was significantly reduced to small size and well-soluble polymers. The best amounts of added Lps in composite films depended upon the kind of phenols. In present study, the mechanical properties, water-absorbing qualities, and thermal properties of biocomposite films showed good results at less than 10% Lps' addition. This provides a possibility that a new kind of biodegradable films can be made up of engineering plastics and lignin. INTRODUCTIONThe development of commercially viable "green products" based on natural resources for both matrices and reinforcements for a wide range of applications is on the rise (Satyanarayana et al. 2009). Lignin, as the second most abundant renewable biopolymer in nature and an inexpensive and currently underutilized waste product from papermaking and biorefinery industries, has been a candidate for renewable materials; however, it is often difficult to blend with other biopolymer due to its complex and irregular structure. So it is necessary to modify lignin.Phenol chemical modification is one kind of method to modify lignin. Recently a class of lignin-based functional polymers, the lignophenols, has originally been designed and their synthesis process from native lignin has been developed. This process includes the phase separation reaction system composed of phenol derivatives and concentrated acid. In the process, native lignin is modified by selectively grafting phenol derivatives to benzyl position. The separated lignin derivatives have several structural characteristics, for example being highly phenolic, very light colored (pinkish white) and highly stable, which is in contrast to conventional lignin (Funaoka et al. 1989). PEER-REVIEWED ARTICLEbioresources.com Qian et al. (2015). "PHB-lignophenol films," BioResources 10(2), 3169-3180. 3170Polyhydroxybutyrate (PHB) is accumulated by a wide variety of micro-organisms as an intracellular storage source of organic carbon and chemical energy. PHB has mechanical strength, elastic modulus, thermal moldability, and biocompatibility. It has attracted much attention as a biocompatible and biodegradable thermoplastic polymer, but its application has often been limited by its brittleness. In recent years, fillers from renewable source have been increasingly used in the preparation of PHB-based biocomposites.Bamboo encompasses 1,250 species within 75 ge...

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Section: Yield Of Lignophenolsmentioning

confidence: 99%

Preparation and Characterization of Polyhydroxybutyrate-Bamboo Lignophenol Biocomposite Films

Qian

Dai

et al. 2015

BioResources

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“…Our previous study indicated that lig-8 is a potent inhibitor of the apoptosis induced by oxidative stress (3). The neuroprotective effect was due to an inhibition of caspase activation, to a prevention of the dissipation of the mitochondrial membrane permeability transition, and to a scavenging of reactive oxygen species (ROS) or reactive nitrogen species (RNS) (3).…”

Section: Introductionmentioning

confidence: 99%

“…The neuroprotective effect was due to an inhibition of caspase activation, to a prevention of the dissipation of the mitochondrial membrane permeability transition, and to a scavenging of reactive oxygen species (ROS) or reactive nitrogen species (RNS) (3). However, it is unknown whether in vitro or in vivo, lig-8 has effects against neuronal damages other than that induced by oxidative stress.…”

Section: Introductionmentioning

confidence: 99%

Lig-8, a Bioactive Lignophenol Derivative From Bamboo Lignin, Protects Against Neuronal Damage In Vitro and In Vivo

Ito

Shimazawa

Akao³

et al. 2006

J Pharmacol Sci

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Abstract. Lig-8, a lignophenol derivative from bamboo lignin, potently suppresses oxidative stress-induced apoptosis. Here, we first examined in vitro whether lig-8 protects against neuronal damage induced by oxygen-glucose deprivation (OGD) followed by reoxygenation, tunicamycin [endoplasmic reticulum (ER)-stress inducer], or PSI (proteasome inhibitor). In pheochromocytoma (PC12) cell cultures, lig-8 (1 to 30 µM) concentration-dependently inhibited OGD-and tunicamycin (2 µg/ ml)-induced cell deaths (significant at ≥3 µM and ≥1 µM, respectively). In human neuroblastoma (SH-SY5Y) cell culture, the PSI-induced apoptotic cell death and fusion protein accumulation (revealing reduced proteasome activity) was inhibited by lig-8 (30 µM). On the other hand, lig-8 at 30 µM alone did not affect any proteasome activity under resting conditions. In vivo, lig-8 (0.1 nmol / eye) reduced intravitreal N-methyl-D-aspartate (NMDA, 20 nmol)-induced retinal damage (decreases in retinal ganglion cells and inner plexiform layer thickness). Hence, lig-8 protects, partly by inhibiting excessive ER-stress, against neuronal damage in vitro and in vivo.

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“…Makino (Gramineae) is a well-known perennial plant growing in Asia, and has been used for burns, hemoptysis, and uremia in traditional medicine [1]. The phytochemical components of Sasa species including triterpenoids, flavonoids, and flavonolignans are of significant interest due to their pharmacological effectiveness to retard spontaneous mammary tumorigenesis and to suppress apoptosis induced by oxidative stress [2] [3]. During our screening to find novel P-gp inhibitory agents, two phenolic constituents, (À)-syringaresinol (1) and tricin (2) isolated from S. borealis, showed potent activity in the present study.…”

mentioning

confidence: 99%

“…The compounds 1 and 2 were evaluated for their inhibitory effects on the P-gp in adriamycin-resistant human breast cancer cells, MCF-7/ADR. Results from cytotoxicity, accumulation, and efflux studies are summarized in the Table and The effect of (À)-syringeresinol (1) on the decrease of the IC 50 value of DNM was a bit stronger than that of tricin (2). But, tricin (2) showed greater activity in increasing DNM accumulation and decreasing DNM efflux.…”

mentioning

confidence: 99%

P‐Glycoprotein Inhibitory Activity of Two Phenolic Compounds, (−)‐Syringaresinol and Tricin from Sasa borealis

Jeong¹,

Chung²,

Han³

et al. 2007

Chemistry & Biodiversity

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A highly bioactive lignophenol derivative from bamboo lignin exhibits a potent activity to suppress apoptosis induced by oxidative stress in human neuroblastoma SH-SY5Y cells

Cited by 62 publications

References 27 publications

Preparation and Characterization of Polyhydroxybutyrate-Bamboo Lignophenol Biocomposite Films

Preparation and Characterization of Polyhydroxybutyrate-Bamboo Lignophenol Biocomposite Films

Lig-8, a Bioactive Lignophenol Derivative From Bamboo Lignin, Protects Against Neuronal Damage In Vitro and In Vivo

P‐Glycoprotein Inhibitory Activity of Two Phenolic Compounds, (−)‐Syringaresinol and Tricin from Sasa borealis

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