A highly efficient microwave-assisted synthesis of an LED-curable methacrylated gelatin for bio applications

Baghban, Sahar Abdollahi; Ebrahimi, Morteza; Bagheri‐Khoulenjani, Shadab; Khorasani, Manouchehr

doi:10.1039/d1ra01269j

Cited by 31 publications

(15 citation statements)

References 61 publications

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“…In Figure S1b, the GelMA spectrum displayed that the peak of CC stretching absorption was concealed by the strong CO stretching peak at 1631 cm –1 . However, C–H bending and CC–H 2 wagging vibrations centered at 556 cm –1 were evidence of successful methacryloyl functionalization of GelMA . Additionally, the absence of a high molecular weight shoulder at shorter retention times in the GPC elution diagrams (Figure S2) suggested that no or minimal premature inter-chain cross-linking or aggregation conducted by the aza-Michael reaction had occurred during the syntheses of CMCSMA and GelMA.…”

Section: Results and Discussionmentioning

confidence: 99%

“…The methyl peak at 1.83 ppm and acrylate peaks at 5.58 and 5.34 ppm confirmed the methacrylation reaction of gelatin. 53 The lysine methylene peaks at 2.85−2.97 ppm and phenylalanine peaks at 7.10−7.31 ppm of gelatin and GelMA spectra were used to calculate the degree of DM of GelMA according to the previous literature. 54 The result showed that the DM of GelMA was about 52.2%.…”

Section: Syntheses and Characterization Of Cmcsma Andmentioning

confidence: 99%

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Lyophilized Platelet-Rich Fibrin Exudate-Loaded Carboxymethyl Chitosan/GelMA Hydrogel for Efficient Bone Defect Repair

Gan

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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Platelet-rich fibrin (PRF) is an autologous growth factor carrier that promotes bone tissue regeneration, but its effectiveness is restrained by poor storage capabilities, uncontrollable concentration of growth factors, unstable shape, etc. Herein, we developed a photocrosslinkable composite hydrogel by incorporating lyophilized PRF exudate (LPRFe) into the carboxymethyl chitosan methacryloyl (CMCSMA)/gelatin methacryloyl (GelMA) hydrogel to effectively solve the dilemma of PRF. The hydrogel possessed suitable physical properties and sustainable release ability of growth factors in LPRFe. The LPRFe-loaded hydrogel could improve the adhesion, proliferation, migration, and osteogenic differentiation of rat bone mesenchymal stem cells (BMSCs). Furthermore, the animal experiments demonstrated that the hydrogel possessed excellent biocompatibility and biodegradability, and the introduction of LPRFe in the hydrogel can effectively accelerate the bone healing process. Conclusively, the combination of LPRFe with CMCSMA/GelMA hydrogel may be a promising therapeutic approach for bone defects.

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Section: Results and Discussionmentioning

confidence: 99%

Section: Syntheses and Characterization Of Cmcsma Andmentioning

confidence: 99%

Lyophilized Platelet-Rich Fibrin Exudate-Loaded Carboxymethyl Chitosan/GelMA Hydrogel for Efficient Bone Defect Repair

Gan

Zhang

et al. 2023

ACS Appl. Mater. Interfaces

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“…As a result, a relatively large amount of DCPD was observed in ASP conditions at 110 s, 5 c and 110 s, 15 c (Figure S3c,d), while DCPD was not observed in ASP conditions at 10, 5 c and 10 s, 15 c (Figure S3a,b). Therefore, DCPD was generated as a byproduct after ASP for a longer immersion time such as 110 s. Raman spectra (Figure S4) also showed that the deposits contained phosphate because peaks were detected that were derived from the P–O stretching vibration, P–O transformation vibration, and P–O unpaired vibration at 960, 400, 600, and 1000 cm –1 …”

Section: Discussionmentioning

confidence: 99%

Microfabrication of Gelatin Methacrylate/Hydroxyapatite Composites by Utilizing Alternate Soaking Process

Miyajima,

Kojima,

Touji

et al. 2023

ACS Biomater. Sci. Eng.

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To construct a complex three-dimensional (3D) structure mimicking bone microstructure, hydrogel models of polymerized gelatin methacrylate (pGelMA) were fabricated by using stereolithography and modified with hydroxyapatite (HAp) via an alternate soaking process (ASP) using a solution of calcium and phosphate ions. Fabricated pGelMA line models whose widths were designed as 100, 300, and 600 μm were modified with HAp by ASP by changing the immersion time and number of cycles.After ASP, all of the line models with widths of 100, 300, and 600 μm were successfully modified with HAp, and large amounts of HAp were covered with the fabricated models by increasing both the immersion time and the number of cycles in ASP. HAp was observed near the surface of the line model with a width of 600 μm after ASP at an immersion time of 10 s, while the entire model was modified with HAp using ASPs for longer immersion times. The adhesion and spread of mesenchymal stem cells (MSCs) on the pGelMA-HAp discs depended on the ASP conditions. Moreover, the HAp modification of 3D pyramid models without alteration of the microstructure was also conducted. This two-step fabrication method of first fabricating frameworks of hydrogel models by stereolithography and subsequently modifying the fabricated models with HAp will lead to the development of 3D cell culture systems to support bone grafts or to create biological niches, such as artificial bone marrow.

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“…The amide III peak arises due to the C−N stretching. 55 Shifting of some peaks is observed toward higher wavenumber. These shifts in the peaks confirm strong interactions between the polymer matrix and the nanofillers.…”

Section: Raman Spectroscopy Analysismentioning

confidence: 96%

Fish Gelatin Reinforced with Carbon Nanotubes and ZnO Nanorods for Wearable Smart Technologies

Mustakim,

Kalam,

Mieno

et al. 2024

ACS Appl. Nano Mater.

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This study presents a comprehensive analysis of a ternary nanocomposite of carbon nanotube (CNT) and ZnOnanorod (ZNR)-reinforced fish gelatin (FG), assessing its potential applications for wearable smart technology. The nanocomposite is prepared by the solution casting method by varying concentrations of nanofillers (0.00, 0.20, 0.25, and 0.30%), where individual nanofillers are taken in the same concentration and analyzed by different characterization techniques to comprehend their interaction. Regarding nanofillers, nearly perfect graphitized CNTs of minimum defects and ZNRs with a high degree of crystallinity with an interlayer spacing of 0.233 nm are used and encapsulation of the nanofillers by the FG matrix is observed. The crystallinity is increased with the initial incorporation of nanofillers but interestingly decreases with higher concentrations. Amide bands are identified with peak shifting, suggesting enhanced interactions between nanofillers and the FG matrix. With the increase in nanofiller concentration, the effects on thermal stability of the nanocomposites and shifting in glass transition and melting temperatures are also investigated. The incorporation of nanofillers significantly improved the mechanical and electrical properties. This study would help to understand the influence of nanofillers in tailoring the properties of nanocomposite, offering opportunities to tune their properties and explore applications in wearable smart technology.

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A highly efficient microwave-assisted synthesis of an LED-curable methacrylated gelatin for bio applications

Abstract: Highly crosslinked gelatin-based hydrogels were prepared via a green technique including a microwave-assisted methacrylation using glycidyl methacrylate or methacrylic anhydride and an LED-curing with a time, energy, and reagent-saving approach.

Cited by 31 publications

References 61 publications

Lyophilized Platelet-Rich Fibrin Exudate-Loaded Carboxymethyl Chitosan/GelMA Hydrogel for Efficient Bone Defect Repair

Lyophilized Platelet-Rich Fibrin Exudate-Loaded Carboxymethyl Chitosan/GelMA Hydrogel for Efficient Bone Defect Repair

Microfabrication of Gelatin Methacrylate/Hydroxyapatite Composites by Utilizing Alternate Soaking Process

Fish Gelatin Reinforced with Carbon Nanotubes and ZnO Nanorods for Wearable Smart Technologies

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