A Highly Rare Cause of Lumbar Spondylodiscitis with Epidural Abscess:<i>Actinomyces israelii</i>

Kapmaz, Mahir; Gülşen, İsmail; Kış, Naciye; Başaran, Seniha; Öksüz, Lütfiye; Gürler, Nezahat

doi:10.1155/2014/469075

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…Vertebral involvement of A. israelii is very rare, especially in the lumbar spine. Only a few cases have been reported for lumbosacral A. israelii infection [8–12]. Although in one case the patient had poor oral hygiene and metastatic prostate cancer [8], in the other cases no obvious risk factor was reported [9–12].…”

Section: Discussionmentioning

confidence: 99%

Lumbar vertebral osteomyelitis and psoas abscess caused by Actinomyces israelii after an operation under general anesthesia in a patient with end-stage renal disease: a case report

Yamada¹,

Kinoshita²,

Nakagawa³

2019

J Med Case Reports

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BackgroundActinomycosis is a chronic, slowly progressive infection caused by the Actinomyces species. Lumbar vertebral involvement of Actinomyces israelii is extremely rare; this is the first case report of lumbar vertebral osteomyelitis and psoas abscess caused by Actinomyces israelii after an operation under general anesthesia.Case presentationA 66-year-old Japanese man with end-stage renal disease was admitted to our hospital for an operation for cervical canal stenosis. After the operation under general anesthesia, during which tracheal intubation and nasogastric tube insertion were performed, he developed low back pain. During a second hospitalization, computed tomography revealed osteolysis of the lumbar endplates of L2 and L3, swelling of the intervertebral disk of L2/L3, and swelling of the left psoas major muscle. Percutaneous drainage of the intervertebral disc was performed, and the culture of the aspirate grew Actinomyces israelii. Based on the susceptibility, ampicillin was administered but his condition did not improve. We changed the antibiotics to ampicillin-sulbactam for coverage of unidentified oral commensals, and his symptoms and signs finally improved.ConclusionOur patient’s long-term end-stage renal disease had made the oral and gastrointestinal mucosal barriers very fragile. Under these conditions, even mildly invasive procedures such as tracheal intubation and nasogastric tube insertion could be the cause of infectious complication by oral commensals, including Actinomyces.

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Section: Discussionmentioning

confidence: 99%

Lumbar vertebral osteomyelitis and psoas abscess caused by Actinomyces israelii after an operation under general anesthesia in a patient with end-stage renal disease: a case report

Yamada¹,

Kinoshita²,

Nakagawa³

2019

J Med Case Reports

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“…This pathogen is also commonly responsible for spinal osteomyelitis/vertebral osteomyelitis. The wound will aggravate as glycemic control deteriorates, causing the immune system to fail to react (36,37).…”

Section: Discitis (Diskitis)mentioning

confidence: 99%

Association of human gut microbiota with rare diseases: A close peep through

Roy

Nag

Saini

et al. 2022

IRDR

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disorders, human gut microbiome, personalized therapeutics, rare diseasesThe human body harbors approximately 10 14 cells belonging to a diverse group of microorganisms. Bacteria outnumbers protozoa, fungi and viruses inhabiting our gastrointestinal tract (GIT), commonly referred to as the "human gut microbiome". Dysbiosis occurs when the balanced relationship between the host and the gut microbiota is disrupted, altering the usual microbial population there. This increases the susceptibility of the host to pathogens, and chances of its morbidity. It is due to the fact that the gut microbiome plays an important role in human health; it influences the progression of conditions varying from colorectal cancer to GIT disorders linked with the nervous system, autoimmunity, metabolism and inheritance. A rare disease is a lethal and persistent condition affecting 2-3 people per 5,000 populaces. This review article intends to discuss such rare neurological, autoimmune, cardio-metabolic and genetic disorders of man, focusing on the fundamental mechanism that links them with their gut microbiome. Ten rare diseases, including Pediatric Crohn's disease (PCD), Lichen planus (LP), Hypophosphatasia (HPP), Discitis, Cogan's syndrome, Chancroid disease, Sennetsu fever, Acute cholecystitis (AC), Grave's disease (GD) and Tropical sprue (TS) stands to highlight as key examples, along with personalized therapeutics meant for them. This medicinal approach addresses the individual's genetic and genomic pathography, and tackles the illness with specific and effective treatments.

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A Highly Rare Cause of Lumbar Spondylodiscitis with Epidural Abscess:Actinomyces israelii

Cited by 2 publications

References 15 publications

Lumbar vertebral osteomyelitis and psoas abscess caused by Actinomyces israelii after an operation under general anesthesia in a patient with end-stage renal disease: a case report

Lumbar vertebral osteomyelitis and psoas abscess caused by Actinomyces israelii after an operation under general anesthesia in a patient with end-stage renal disease: a case report

Association of human gut microbiota with rare diseases: A close peep through

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