A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content

Hariri, Niloofar; Gougeon, Réjeanne; Thibault, Louise

doi:10.1016/j.nutres.2010.09.003

Cited by 86 publications

(59 citation statements)

References 60 publications

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“…The consistent rise in obesity rates have been attributed to the overconsumption of foods rich in fats, namely saturated fats and cholesterol (Piers et al 2003;Hariri et al 2010). Similarly, the prevalence of NAFLD and non-alcoholic steatohepatitis (NASH) are on the rise, and such a trend has been linked to dietary fat induced hepatotoxicity and adiposity (Gaemers et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Regular consumption of saturated fats and cholesterol promote weight gain and exacerbate the development of obesity; an antecedent condition from which other metabolic disorders including Type 2 diabetes mellitus, metabolic syndrome, and non-alcoholic fatty liver disease (NAFLD) arise (Golay and Bobbioni 1997;Hariri et al 2010;Gaemers et al 2011). Oxidative stress is a common feature in those chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

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Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase

SarnaLindsei

WuNan

WangPengqi

et al. 2012

Can. J. Physiol. Pharmacol.

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Diets high in saturated fat and cholesterol facilitate weight gain, a predisposing factor that contributes to the onset of obesity and metabolic disorders. Hepatic oxidative stress is commonly reported in various animal models of obesity and has been associated with enhanced expression of NADPH oxidase. We have previously reported several antioxidant mechanisms through which folic acid confers protection during hyperhomocysteinemia-induced oxidative stress. The objective of the present study was to investigate whether folic acid supplementation ameliorates high-fat diet induced oxidative stress in the liver, and to identify the underlying mechanisms. Male C57BL/6J mice were fed a control diet, a high-fat diet, or a high-fat diet supplemented with folic acid for 12 weeks. A high-fat diet led to increased body mass, hepatic lipid peroxidation, and liver injury. There was a significant increase in hepatic NADPH oxidase activity, which was associated with enhanced expression of several NADPH-oxidase subunits. Folic acid supplementation had a protective effect against high-fat diet induced hepatic oxidative stress and liver injury. Further analysis revealed that the antioxidant effect of folic acid was attributed, in part, to transcriptional regulation of NADPH oxidase. These results suggested that folic acid supplementation may be hepatoprotective from liver injury associated with a high-fat diet.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase

SarnaLindsei

WuNan

WangPengqi

et al. 2012

Can. J. Physiol. Pharmacol.

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“…1d). The excess energy content, mainly as SFA, led to the buildup of adiposity and body weight [20]. In this line, there is much evidence that demonstrate a high-fat accumulation when more energy comes from dietary fat than from carbohydrate or protein.…”

Section: Discussionmentioning

confidence: 99%

High-fat diet based on dried bovine brain: an effective animal model of dyslipidemia and insulin resistance

et al. 2011

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Currently, there are no reports in the literature demonstrating any animal model that ingests one of the fattiest animal food source, the bovine brain. We hypothesized that a high-fat diet (HFD), based on dried bovine brain, could be used to develop an animal model possessing a spectrum of insulin resistance-related features. The HFD was formulated with 40% dried bovine brain plus 16.4% butter fat, prepared in-house. Furthermore, the diet contained 52% calories as fat and 73% of total fatty acids were saturated. Swiss mice weighing about 40 g were assigned to two dietary groups (n=6/group), one group received a standard chow diet and the other was given HFD for 3 months. The body weight and biochemical parameters of the animals were measured initially and at monthly intervals until the end of the experiment. Animals fed on a HFD showed a significant increase in the body and adipose tissue weight, serum total cholesterol and triglyceride levels, when compared with mice fed on the control diet. Additionally, the HFD group showed higher circulating levels of liver transaminases, such as alanine aminotransferase and aspartate aminotransferase, compared with the control group. Finally, to illustrate the usefulness of this model, we report that the HFD induced mild hyperglycemia, fasting hyperinsulinemia, and increased the homeostasis model of assessment (HOMA-IR), in comparison with the control group. In conclusion, our results show that HFD, based on dried bovine brain, causes insulin resistance-related metabolic disturbances. Thus, this may be a suitable model to study disturbances in energy metabolism and their consequences.

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“…Excessive fat intake can promote an imbalance between energy intake and energy expenditure, which could increase the risk of obesity [8]. Moreover, the association between weight gain inherent to menopause [1] and the one due to a diet with a high fat intake [8], is bad for menopausal women and can lead to an increased risk of cardiovascular disease, breast cancer and even of neurodegenerative diseases [9]. In Morocco, argane and olive oils play an important role in the national economy.…”

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confidence: 99%

Impact of Consumption of Olive and Argane Oils on Anthropometric Profile of Postmenopausal Women in Morocco

Labraimi¹,

Mzibri²,

Derouiche³

et al. 2015

JAST-B

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Abstract:Worldwide, large studies have shown that the menopause is mainly associated with substantial changes in body composition that result in an increase in waist circumference, fat accumulation and specially weight gain. This overweight could be exacerbated by fat intake. Thus, this study was planned to evaluate the impact of the consumption of olive and argane oils on anthropometric profile and body composition of postmenopausal women. The nutritional intervention was conducted over a period of eight weeks, involving daily consumption of 25 mL of argane oil or olive oil in 151 postmenopausal women (55.49 ± 6.18 years old). The anthropometric profile (weight, height and body mass index (BMI)) and body composition (fat mass (FM) and lean mass (LM)) were determined at 0 week (baseline), and after the 4th and 8th weeks of nutritional intervention. Results clearly demonstrated that argane oil or olive oil consumption did not affect the anthropometric parameters and the body composition of postmenopausal women. Thus, argane and/or olive oils' regular diet does not lead to weight gain, and postmenopausal women could benefit from their impact on health for a better quality of life and to overcome all menopause associated problems. A longer period of nutritional intervention is required to confirm the trend down that was recorded.

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A highly saturated fat-rich diet is more obesogenic than diets with lower saturated fat content

Cited by 86 publications

References 60 publications

Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase

Folic acid supplementation attenuates high fat diet induced hepatic oxidative stress via regulation of NADPH oxidase

High-fat diet based on dried bovine brain: an effective animal model of dyslipidemia and insulin resistance

Impact of Consumption of Olive and Argane Oils on Anthropometric Profile of Postmenopausal Women in Morocco

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