A highly selective amperometric biosensor array for the simultaneous determination of glutamate, glucose, choline, acetylcholine, lactate and pyruvate

Kucherenko, D. Yu.; Кучеренко, І. С.; Солдаткін, О. О.; Topolnikova, Ya. V.; Dzyadevych, S. V.

doi:10.1016/j.bioelechem.2019.03.010

Cited by 40 publications

(13 citation statements)

References 37 publications

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“…Free GOx enzyme operates under a relatively broad pH range (pH 4–7) and its optimum working pH is 5.5, [ 26 ] yet after enzyme immobilization its optimum pH can change. [ 27 ] According to the results represented in Figure S2, Supporting Information, there was no significant response to glucose at pH 6.2. With the increase of pH, response to glucose also increased reaching its maximum at pH 7.4.…”

Section: Resultsmentioning

confidence: 99%

Transdermal Electrochemical Monitoring of Glucose via High‐Density Silicon Microneedle Array Patch

Dervisevic

Alba

et al. 2021

Adv Funct Materials

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Current technology for blood glucose level monitoring is mainly based on the invasive finger‐prick extraction of a small drop of blood using a lancet and measured via a handheld glucometer, which is not conducive to continuous measurements. Interstitial fluid (ISF) is gaining attention as an alternative biofluid. Its biochemical composition is very similar to that of blood and it can be monitored in a continuous manner via minimally invasive methods that cause no pain and minimize any risk of infection. Herein, a microneedle array (MNA) based transdermal sensing system for the pain free monitoring of ISF glucose is presented. High‐density silicon microneedles (≈9500 microneedles cm−2) are used to prepare a three‐electrode patch for the electrochemical monitoring of glucose. The MNA glucose patch shows very good selectivity when tested in artificial ISF, with a sensitivity of 0.1622 µA mm−1 cm−2 and a detection limit of 0.66 mm. In vivo application of the microneedle array in mice shows that the ISF glucose concentrations obtained with the MNA sensor gave very good correlation with the blood glucose levels determined with a commercial glucometer. This microneedle‐based sensing system hence provides an alternative transdermal diagnostic tool to the invasive existing techniques.

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Section: Resultsmentioning

confidence: 99%

Transdermal Electrochemical Monitoring of Glucose via High‐Density Silicon Microneedle Array Patch

Dervisevic

Alba

et al. 2021

Adv Funct Materials

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“…186 Moreover, Kucherenko et al presented a biosensor array for the simultaneous determination of glutamate, glucose, choline, acetylcholine, lactate and pyruvate, by immobilizing selective enzymes on the surface of amperometric platinum disc electrodes, demonstrating good selectivity and reproducibility capabilities. 187 In health monitoring, Guerrieri et al presented a novel highly selective amperometric biosensor for choline determination in patients with renal diseases based on choline oxidase immobilized by co-crosslinking on a Pt electrode with a novel anti-fouling and anti-interferent membrane, that aim to improve the interference rejection, stability and selectivity of the device. 188 Furthermore, Vargas et al proposed an amperometric biosensor for miRNA-21 detection for diagnosis or prognostic in patients with breast cancer.…”

Section: Electrochemical Nanosensorsmentioning

confidence: 99%

Review—Bio-Nanosensors: Fundamentals and Recent Applications

Perdomo

Marmolejo‐Tejada

Jaramillo-Botero

2021

J. Electrochem. Soc.

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“…The sensor performed well in the concentrations 0-16 mM for glucose and 0.005-6 mM for H 2 O 2 . An amperometric biosensor array comprising of phenylenediamine modified transducers was fabricated for the detection of choline, glutamate, glucose, lactate, acetylcholine and pyruvate in CSF (cerebrospinal fluid) and blood plasma within a minute and exhibiting a linear range prevailing between 0.001-0.01 and 0.2-2.5mM and limit of detection (LOD) of 1-5 µM [96]. Several other combinations of nanointerfaces and electrode materials have been reported for the detection of glucose and H 2 O 2 that are summarized in Table 3.…”

Section: Electrochemical Detection Strategies For Multi-analyte Detecmentioning

confidence: 99%

Metabolic Syndrome—An Emerging Constellation of Risk Factors: Electrochemical Detection Strategies

Madhurantakam

Devi

Babu

et al. 2019

Sensors

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Metabolic syndrome is a condition that results from dysfunction of different metabolic pathways leading to increased risk of disorders such as hyperglycemia, atherosclerosis, cardiovascular diseases, cancer, neurodegenerative disorders etc. As this condition cannot be diagnosed based on a single marker, multiple markers need to be detected and quantified to assess the risk facing an individual of metabolic syndrome. In this context, chemical- and bio-sensors capable of detecting multiple analytes may provide an appropriate diagnostic strategy. Research in this field has resulted in the evolution of sensors from the first generation to a fourth generation of ‘smart’ sensors. A shift in the sensing paradigm involving the sensing element and transduction strategy has also resulted in remarkable advancements in biomedical diagnostics particularly in terms of higher sensitivity and selectivity towards analyte molecule and rapid response time. This review encapsulates the significant advancements reported so far in the field of sensors developed for biomarkers of metabolic syndrome.

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A highly selective amperometric biosensor array for the simultaneous determination of glutamate, glucose, choline, acetylcholine, lactate and pyruvate

Cited by 40 publications

References 37 publications

Transdermal Electrochemical Monitoring of Glucose via High‐Density Silicon Microneedle Array Patch

Transdermal Electrochemical Monitoring of Glucose via High‐Density Silicon Microneedle Array Patch

Review—Bio-Nanosensors: Fundamentals and Recent Applications

Metabolic Syndrome—An Emerging Constellation of Risk Factors: Electrochemical Detection Strategies

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