A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation

Nakamura, Yuki; Urakami, Takeo; Ishimaru, Kayoko; Vuong Tran, Nguyen Quoc; Shimizu, Takafumi; Sinko, William; Takahashi, Taisuke; Marappan, Sivapriya; Narayanan, Kishore; Poddutoori, Ramulu; Terada, Yoh; Nakao, Atsuhito

doi:10.1016/j.jacig.2024.100249

Journal of Allergy and Clinical Immunology: Global

2024

DOI: 10.1016/j.jacig.2024.100249

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A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation

Yuki Nakamura,

Takeo Urakami,

Kayoko Ishimaru

et al.

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Cited by 2 publications

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ModBind, a Rapid Simulation-Based Predictor of Ligand Binding and Off-Rates

Sinko,

Mertz,

Shimizu

et al. 2024

J. Chem. Inf. Model.

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ModBind, a Rapid Simulation-Based Predictor of Ligand Binding and Off-Rates

Sinko,

Mertz,

Shimizu

et al. 2024

J. Chem. Inf. Model.

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TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa

Roers

2025

Journal of Clinical Investigation

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Similarly to acute intestinal helminth infection, several conditions of chronic eosinophilic type 2 inflammation of mucosal surfaces, including asthma and eosinophilic esophagitis, feature robust expansions of intraepithelial mast cells (MCs). Also the hyperplastic mucosa of nasal polyposis in the context of chronic rhinosinusitis, with or without COX1 inhibitor intolerance, contains impressive numbers of intraepithelial MCs. In this issue of the JCI , Derakhshan et al. elucidate the heterogeneity of MCs in nasal polyposis and identify a transcriptional signature of TGF-β target genes expressed by the intraepithelial MC population. These MCs displayed effector functions that implicate them as pathogenetic contributors. TGF-β directed differentiation of similar MC populations also in vitro. These findings extend the emerging concept of TGF-β as a driver of type 2 inflammation at barrier surfaces.

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A highly selective KIT inhibitor MOD000001 suppresses IgE-mediated mast cell activation

Cited by 2 publications

References 21 publications

ModBind, a Rapid Simulation-Based Predictor of Ligand Binding and Off-Rates

ModBind, a Rapid Simulation-Based Predictor of Ligand Binding and Off-Rates

TGF-β drives differentiation of intraepithelial mast cells in inflamed airway mucosa

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