A highly sensitive acidic pH fluorescent probe and its application to E. coli cells

Chao, Jianbin; Wang, Huijuan; Song, Kailun; Li, Zhiqing; Zhang, Yongbin; Yin, Caixia; Huo, Fangjun; Wang, Juanjuan; Zhang, Ting

doi:10.1016/j.tet.2016.11.013

Cited by 20 publications

(7 citation statements)

References 49 publications

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“…They are also inert to nonhalogen OP compounds and common solvents and are therefore less susceptible to false positives from these latter analytes. However, it should be noted that fluorophores with N‐containing moieties including arylamine, pyridine, and benzothiazole, are also excellent protonation‐induced fluorescence “turn on” pH sensors. This means that the N‐containing materials designed for the detection of nerve agents and simulants are intrinsically sensitive to acids.…”

Section: Potential For False Positive Responses From Acidsmentioning

confidence: 99%

Challenges in Fluorescence Detection of Chemical Warfare Agent Vapors Using Solid‐State Films

et al. 2019

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Organophosphorus (OP)‐based nerve agents are extremely toxic and potent acetylcholinesterase inhibitors and recent attacks involving nerve agents highlight the need for fast detection and intervention. Fluorescence‐based detection, where the sensing material undergoes a chemical reaction with the agent causing a measurable change in the luminescence, is one method for sensing and identifying nerve agents. Most studies use the simulants diethylchlorophosphate and di‐iso‐propylfluorophosphate to evaluate the performance of sensors due to their reduced toxicity relative to OP nerve agents. While detection of nerve agent simulants in solution is relatively widely reported, there are fewer reports on vapor detection using solid‐state sensors. Herein, progress in organic semiconductor sensing materials developed for solid‐state detection of OP‐based nerve agent vapors is reviewed. The effect of acid impurities arising from the hydrolysis of simulants and nerve agents on the efficacy and selectivity of the reported sensing materials is also discussed. Indeed, in some cases it is unclear whether it is the simulant that is detected or the acid hydrolysis products. Finally, it is highlighted that while analyte diffusion into the sensing film is critical in the design of fast, responsive sensing systems, it is an area that is currently not well studied.

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Section: Potential For False Positive Responses From Acidsmentioning

confidence: 99%

Challenges in Fluorescence Detection of Chemical Warfare Agent Vapors Using Solid‐State Films

et al. 2019

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“…Before the addition of acid, DMSO solution of TBPP exhibited an intense emission band around 490 nm with a large Stokes shi of 149 nm. 29,30,34,35 The large Stokes shi should help to reduce the excitation interference. Upon increasing the amount of H + , the uorescence intensity reduced gradually until quenched completely.…”

Section: Ph Titrations Of Probe Tbppmentioning

confidence: 99%

An acidic pH fluorescent probe based on Tröger's base

Yuan

Zhang

et al. 2017

RSC Adv.

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“…As one kind of important probes, pyridine derivatives are used widely as a lot of sensors including pH probes. [28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] The nitrogen atom within the pyridine ring has been widely used because of the combinable nature between the lone pair electron of nitrogen and proton. In addition, some groups reported a lot of compounds that bridged pyridine and aryl groups through acrylonitrile and respectively studied their properties such as kinetics, spectroscopy, pH sensing, lightemitting diodes, etc.…”

Section: Introductionmentioning

confidence: 99%

“…As one kind of important probes, pyridine derivatives are used widely as a lot of sensors including pH probes [28–45] . The nitrogen atom within the pyridine ring has been widely used because of the combinable nature between the lone pair electron of nitrogen and proton.…”

Section: Introductionmentioning

confidence: 99%

Two Pyridine‐Based Fluorescent Probes for Sensing pH

Sun

Wei

2020

ChemistrySelect

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Two pyridine‐based isomeric fluorescent probes, 3‐(4‐dimethylamino‐phenyl)‐2‐pyridin‐3‐yl‐acrylonitrile (1) and 3‐(4‐dimethylamino‐phenyl)‐2‐pyridin‐4‐yl‐acrylonitrile (2), were successfully designed, synthesized and characterized with NMR, LC‐MS and HRMS methods. Both probes are pH‐reversible, showing an excellent selectivity toward H+ than other coexisting metal ions. They display good linear response within the extreme‐acidity range of 1.85–2.75 with the pKa of 2.28 for 1, and that of 2.65–4.17 with the pKa of 3.15 for 2, respectively. The probe 2 has the ratiometric fluorescence emission (I513nm/I570nm) characteristics and could be used as a sensor of acidity. The color of 2 is changed from yellow to pink, allowing colorimetric detection of pH by the naked eyes. In addition, both 1 and 2 could be used for monitoring pH in Escherichia coli (E. coli) cells under the extremely acidic conditions.

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A highly sensitive acidic pH fluorescent probe and its application to E. coli cells

Cited by 20 publications

References 49 publications

Challenges in Fluorescence Detection of Chemical Warfare Agent Vapors Using Solid‐State Films

Challenges in Fluorescence Detection of Chemical Warfare Agent Vapors Using Solid‐State Films

An acidic pH fluorescent probe based on Tröger's base

Two Pyridine‐Based Fluorescent Probes for Sensing pH

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