A Highly Sensitive and Selective Turn‐On Fluorogenic and Chromogenic Sensor Based on BODIPY‐Functionalized Magnetic Nanoparticles for Detecting Lead in Living Cells

Abstract

A new fluoro-chromogenic chemosensor based on BODIPY-functionalized Fe(3)O(4)@SiO(2) core/shell nanoparticles 1 has been prepared. Chemosensor 1 exhibits a high affinity and selectivity for Pb(2+) over competing metal ions tested. Moreover, confocal microscopy, and flow cytometry experiments established that 1 can be used for detecting Pb(2+) levels within living cell.

Synthesis and characterization of Bodipy functionalized magnetic iron oxide nanoparticles for potential bioimaging applications

“…Due to their unique photophysical properties, Bodipy dyes are of considerable interest for potential applications such as bioimaging, sensor applications [19]. Jung and co-workers [20] Fe 3 O 4 nanocrystals within silica shells via microemulsion method. Then, Bodipy fluorophore having triethoxysilane functional groups was covalently attached on the surface of Fe 3 O 4 @SiO 2 nanoparticles by sol-gel method.…”

A Mesoporous, Silica‐Immobilized‐Nanoparticle Colorimetric Chemosensor for the Detection of Nerve Agents

“…Silica‐based nanoparticles are of great interest for biomedical‐ and environmental‐research applications such as bioseparation, drug targeting, cell isolation, enzyme immobilization, and protein purification because of their biocompatibility and stability against degradation 6–10. It is clear that receptor‐immobilized nanoparticles have some important advantages as solid chemosensors.…”

Membrane-based detection of lead ions in seawater, urine and drinking straws through laser desorption/ionization

“…Notably, this large sample volume improved the detection sensitivity by up to 50-fold as a result of the concentration of Pb 2+ ions onto the MCEM from a very dilute aqueous solution. Although this LOD is not comparable with that obtainable using ICP-MS, it is at least one order of magnitude lower than those provided by optical and electrochemical sensors for Pb 2+ ions [49][50][51][52][53][54][55][56][57][58][59][60]. In addition, the detection of Pb 2+ by MCEM/LDI-MS is relatively simple, rapid and high-throughput when compared to ICP-MS.…”

“…Therefore, our MCEM/LDI-MS sensing system is a practical tool for the determination of Pb 2+ ions in complicated biological samples. Notably, most probes based on organic chemosensors or NPs are rarely applied for the determination of Pb 2+ ions in such complex biological samples [49][50][51][52][53][54][55][56][57][58][59][60].…”