A highly specific far-red fluorescent probe for imaging endogenous peroxynitrite in the mitochondria of living cells

Zhu, Baocun; Zhang, Meng; Liu, Wu; Zhao, Ziyang; Liu, Caiyun; Wang, Zuokai; Duan, Qingxia; Wang, Yawei; Jia, Pan

doi:10.1016/j.snb.2017.10.170

Cited by 97 publications

(35 citation statements)

References 50 publications

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“…ONOO – has high reactivity and excellent membrane permeability, which makes it an ideal intracellular regulator toward diverse biomacromolecules 45,46,78. It has been reported that ONOO – is involved in the development of numerous major diseases, such as cardiovascular disease, neurodegenerative disease, acute inflammation and cancer 44,47,79. Therefore, fluorescent probes for tracing the subcellular ONOO – levels during different processes are of significant importance.…”

Section: Mitochondrion-targeted Probesmentioning

confidence: 99%

Fluorescent probes for organelle-targeted bioactive species imaging

et al. 2019

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The dynamic fluctuations of bioactive species in living cells are associated with numerous physiological and pathological phenomena. The emergence of organelle-targeted fluorescent probes has significantly facilitated our understanding on the biological functions of these species. This review describes the design, applications, challenges and potential directions of organelle-targeted bioactive species probes.

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Section: Mitochondrion-targeted Probesmentioning

confidence: 99%

Fluorescent probes for organelle-targeted bioactive species imaging

et al. 2019

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“…Specifically, the colorimetric fluorescence probes stand out from numerous detection methods because they allow the target analytes to be detected using the naked‐eye, therefore needing no help from other sophisticated instruments . Also, they have the advantages of simple synthesis, high selectivity and sensitivity . Due to the long‐wavelength the fluorescent probe possesses several merits, such as more obvious color change, better tissue penetration, and minimum interference from background auto‐fluorescence by biomolecules, therefore it has attracted intense interest of researchers.…”

Section: Introductionmentioning

confidence: 99%

A highly selective colorimetric and long‐wavelength fluorescent probe for the detection of Hg²⁺

Wang

Liu

et al. 2018

Luminescence

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Currently, the fluorescent probe is an important method for detecting heavy metal ions, especially mercury ion (Hg ), which is harmful to the health of humans and the environment due to its toxicity and extensive use. In this paper, we designed and synthesized a colorimetric and long-wavelength fluorescent probe Hg-P with high sensitivity and excellent selectivity, which could detect Hg by the changes of visual color, fluorescence and absorption spectroscopy. With the addition of Hg to probe Hg-P solution, its color changed from yellow to pink, and showed a 171 nm red-shifted absorption spectrum. Probe Hg-P was used in real water and soil solution samples to detect Hg , and the result is satisfactory. Therefore, this new probe shows great value and application in detecting Hg in the environment.

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“…Recently, a number of fluorescent probes for ONOO – imaging in living cells have been developed. − Compared with one-photon fluorescent probes for ONOO – detection, two-photon fluorescent probes exhibit higher temporal spatial resolution, deeper imaging depth, and less background fluorescence and photobleaching. − Furthermore, ratiometric fluorescent probes with two emission signals were known to effectively mitigate the substantial interferences, including instrumental parameters, probe microenvironment and concentration, photobleaching, and so on. − Among them, Cheng et al developed an excellent fluorescence resonance energy transfer (FRET)-based probe for ONOO – imaging which possesses both two-photon and ratiometric properties . In general, the distance of FRET-based probes between energy donors and acceptors needs to be accurately regulated or the FRET efficiency would be seriously affected.…”

mentioning

confidence: 99%

Visualization of Lung Inflammation to Pulmonary Fibrosis via Peroxynitrite Fluctuation

Zhan¹,

Liu²,

Chai

et al. 2019

Anal. Chem.

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Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disease with short survival time. However, owing to the unknown etiology and the lack of sensitive and noninvasive methods, the diagnosis of IPF in the early stage is still full of challenges. Since the levels of oxidative stress in mitochondria are relevant to pulmonary fibrosis, we herein present a simultaneous near-infrared (NIR)-Ia window and ratiometic fluorescent probe, rTPONOO-1, with two-photon and mitochondria-targeting abilities to explore the potential biological roles of peroxynitrite (ONOO − ) in different states of lung slices from healthy to lung inflammation and pulmonary fibrosis, and there is a good linear relationship between ratiometric fluorescence changes and the rate of pulmonary fibrosis from hematoxylin and eosin (H&E) and Masson staining. In addition, the therapeutic efficacy of aminoguanidine hemisulfate salt (AG) was also investigated. Thus, rTPONOO-1 has great potential in quickly predicting the progression of pulmonary fibrosis in the early stage and improving effective treatment.

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A highly specific far-red fluorescent probe for imaging endogenous peroxynitrite in the mitochondria of living cells

Cited by 97 publications

References 50 publications

Fluorescent probes for organelle-targeted bioactive species imaging

Fluorescent probes for organelle-targeted bioactive species imaging

A highly selective colorimetric and long‐wavelength fluorescent probe for the detection of Hg²⁺

Visualization of Lung Inflammation to Pulmonary Fibrosis via Peroxynitrite Fluctuation

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A highly specific far-red fluorescent probe for imaging endogenous peroxynitrite in the mitochondria of living cells

Cited by 97 publications

References 50 publications

Fluorescent probes for organelle-targeted bioactive species imaging

Fluorescent probes for organelle-targeted bioactive species imaging

A highly selective colorimetric and long‐wavelength fluorescent probe for the detection of Hg2+

Visualization of Lung Inflammation to Pulmonary Fibrosis via Peroxynitrite Fluctuation

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A highly selective colorimetric and long‐wavelength fluorescent probe for the detection of Hg²⁺