A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

Zhao, Zhennan; Gao, Pan; Ma, Li; Chen, Tianfeng

doi:10.1039/d0sc00862a

Cited by 31 publications

(21 citation statements)

References 37 publications

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“…Most recently, a cyclometallated Ir III compound (Ir5 †) was reported to localise in mitochondria and to produce increased radiosensitisation in cancer cells compared to cisplatin, attributable to increased ROS production upon X-ray irradiation. 81 Synchrotron stereotactic radiotherapy (SSR) is a type of external-beam irradiation, which exploits high-uence monochromatic X-ray beams to treat cancer. The presence of heavy elements can enhance the therapeutic effect if the X-ray beam is tuned to the energy of the K-electrons of the sensitiser.…”

Section: Ionising Radiation Sonodynamic and Thermal Activationmentioning

confidence: 99%

Metallodrugs are unique: opportunities and challenges of discovery and development

et al. 2020

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Section: Ionising Radiation Sonodynamic and Thermal Activationmentioning

confidence: 99%

Metallodrugs are unique: opportunities and challenges of discovery and development

et al. 2020

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“…The results of our group and numerous other studies show that ROS could be used as a target or biosignature for the treatment of various diseases (Huang et al, 2017(Huang et al, , 2020Mei et al, 2018;Lai et al, 2019;He et al, 2020;Yang et al, 2020a,c;Zhao et al, 2020). Reactive oxygen species-responsive materials refers to materials capable of responding to those elevated ROS, such as H 2 O 2 , O 2•− , 1 O 2 , and so on.…”

Section: Ros-responsive Nanocarriers and Their Applicationsmentioning

confidence: 80%

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Liu

Chen

et al. 2020

Front. Chem.

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Numerous pathological conditions, including cancer, inflammatory diseases, and neurodegenerative diseases, are accompanied by overproduction of reactive oxygen species (ROS). This makes ROS vital flagging molecules in disease pathology. ROS-responsive drug delivery platforms have been developed. Nanotechnology has been broadly applied in the field of biomedicine leading to the progress of ROS-responsive nanoparticles. In this review, we focused on the production and physiological/pathophysiological impact of ROS. Particular emphasis is put on the mechanisms and effects of abnormal ROS levels on oxidative stress diseases, including cancer, inflammatory disease, and neurodegenerative diseases. Finally, we summarized the potential biomedical applications of ROS-responsive nanocarriers in these oxidative stress diseases. We provide insights that will help in the designing of new ROS-responsive nanocarriers for various applications.

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“…In addition, the isobologram method previously described was introduced to analyze the synergy effect between Te nanomaterials and X-ray. 57 If the data point is lower than the straight line, then this remarks the synergism.…”

Section: Methodsmentioning

confidence: 98%

“…After incubation for another 24 h, the viabilities of combined treatment of Te nanomaterials and X-ray were measured by MTT assay. In addition, the isobologram method previously described was introduced to analyze the synergy effect between Te nanomaterials and X-ray . If the data point is lower than the straight line, then this remarks the synergism.…”

Section: Methodsmentioning

confidence: 99%

Shape-Controllable Tellurium-Driven Heterostructures with Activated Robust Immunomodulatory Potential for Highly Efficient Radiophotothermal Therapy of Colon Cancer

Huang

Zhang

et al. 2021

ACS Nano

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Tellurium (Te)-based semiconductor easily leads to the recombination of photogenerated electron–hole pairs (h+–e–) that severely limits the efficiency of reactive oxygen species (ROS) generation and further hinders its clinical application in biomedicine. With regard to these problems, herein we designed and synthesized a Te heterostructure (BTe-Pd-Au) by incorporating palladium (Pd) and gold (Au) elements to promote its radiosensitivity and photothermal performance, thus realizing highly efficient radiophotothermal tumor elimination by activating robust immunomodulatory potential. This shape-controllable heterostructure that coated by Pd on the surface of Te nanorods and Au in the center of Te nanorods was simply synthesized by using in situ synthesis method, which could promote the generation and separation of h+–e– pairs, thereby exhibiting superior ROS producing ability and photothermal conversion efficiency. Using a mouse model of colon cancer, we proved that BTe-Pd-Au-R-combined radiophotothermal therapy not only eradicated tumor but also elicited to a series of antitumor immune responses by enhancing the cytotoxic T lymphocytes, triggering dendritic cells maturation, and decreasing the percentage of M2 tumor-associated macrophages. In summary, our study highlights a facile strategy to design Te-driven heterostructure with versatile performance in radiosensitization, photothermal therapy, and immunomodulation and offers great promise for clinical translational treatment of colon cancer.

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A highly X-ray sensitive iridium prodrug for visualized tumor radiochemotherapy

Abstract: A highly X-ray sensitive molecular prodrug, Ir-NB, was reported for visualized tumor radiochemotherapy. To our knowledge, the sensitivity enhancement ratio of the prodrug is the highest among the reported radiotherapy metal complexes drugs.

Cited by 31 publications

References 37 publications

Metallodrugs are unique: opportunities and challenges of discovery and development

Metallodrugs are unique: opportunities and challenges of discovery and development

Biomedical Application of Reactive Oxygen Species–Responsive Nanocarriers in Cancer, Inflammation, and Neurodegenerative Diseases

Shape-Controllable Tellurium-Driven Heterostructures with Activated Robust Immunomodulatory Potential for Highly Efficient Radiophotothermal Therapy of Colon Cancer

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