A Hill type model of rat medial gastrocnemius muscle that accounts for shortening history effects

Meijer, K.; Grootenboer, H.J.; Koopman, Bart; Linden, B.J.J.J. van der; Huijing, P.A.J.B.M.

doi:10.1016/s0021-9290(98)00048-7

Cited by 60 publications

(52 citation statements)

References 22 publications

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“…This implies that the inhibition of cross-bridges in the newly formed overlap zone alone cannot explain all of the observed force depression. All skinned fibres showed force depression, which increased with increasing shortening magnitudes, thereby confirming results in human muscle (De Ruiter et al, 1998;Lee and Herzog, 2003;Rousanoglou et al, 2007), whole isolated muscle (Abbott and Aubert, 1952;Herzog and Leonard, 1997;Marechal and Plaghki, 1979;Meijer et al, 1998;Morgan et al, 2000) and single fibre preparations (Granzier and Pollack, 1989;Sugi and Tsuchiya, 1988). As skinned fibres are formed of myofibrils arranged in parallel and in series, we suggest that mechanisms occurring within myofibrils and in particular within sarcomeres likely contribute to force depression.…”

Section: Discussionsupporting

confidence: 85%

New insights into force depression in skeletal muscle

Joumaa

MacIntosh

Herzog

2012

Journal of Experimental Biology

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SUMMARYForce depression observed following active shortening is not well understood. Previous research suggested that force depression might be associated with a stress-induced inhibition of cross-bridges in the newly formed overlap zone following shortening. Our aim was to investigate this theory in skinned fibres and determine whether there was an inhibition of the attachment of cross-bridges or a decrease in the force produced per cross-bridge. The stress-induced inhibition of cross-bridge theory gives testable predictions, including: (1) skinned fibres should show proportional force and stiffness depression, (2) force after shortening should not be lower than force before shortening, (3) stiffness following shortening should not be lower than stiffness before shortening and (4) force depression should decrease when the stress during shortening is decreased. In agreement with these predictions, force and stiffness depression were approximately proportional, and force depression decreased with decreasing stress during shortening. However, in contrast to the predictions of the stress-induced inhibition of cross-bridge theory, force after shortening from sarcomere lengths of 2.8 and 3.0m to a sarcomere length of 2.4m was smaller than force before shortening, and this was not accompanied by a corresponding decrease in stiffness. We conclude that the stress-induced inhibition of cross-bridge theory, as proposed previously, cannot be the only mechanism for force depression, but that there is an additional, stress-induced inhibition of cross-bridges in the old overlap zone. Furthermore, both mechanisms, inhibition of cross-bridge attachment and reduction of force produced per cross-bridge, contribute to force depression. Inhibition and/or reduction of force depend(s) on the amount of stress imposed on actin during the shortening phase.

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Section: Discussionsupporting

confidence: 85%

New insights into force depression in skeletal muscle

Joumaa

MacIntosh

Herzog

2012

Journal of Experimental Biology

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“…This force depression (FD) has been observed in all muscle preparations, ranging from whole muscles (Abbott and Aubert, 1952;Herzog and Leonard, 1997;Maréchal and Plaghki, 1979;Meijer et al, 1998;Morgan et al, 2000) to human skeletal muscles (De Ruiter et al, 1998;Lee and Herzog, 2003;Power et al, 2014), single fibres (Edman et al, 1993;Granzier and Pollack, 1989;Joumaa et al, 2012;Julian and Morgan, 1979;Minozzo and Rassier, 2013;Sugi and Tsuchiya, 1988) and myofibrils (Joumaa and Herzog, 2010). Force depression increases with increasing shortening magnitudes (Abbott and Aubert, 1952;Herzog and Leonard, 1997;Maréchal and Plaghki, 1979), and decreases with increasing shortening speeds (Abbott and Aubert, 1952;Herzog and Leonard, 1997;Leonard and Herzog, 2005;Maréchal and Plaghki, 1979;Morgan et al, 2000).…”

Section: Introductionmentioning

confidence: 94%

Energy cost of isometric force production after active shortening in skinned muscle fibres

Joumaa

Fitzowich

2017

Journal of Experimental Biology

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The steady-state isometric force after active shortening of a skeletal muscle is lower than the purely isometric force at the corresponding length. This property of skeletal muscle is known as force depression. The purpose of this study was to investigate whether the energy cost of force production at the steady state after active shortening was reduced compared with the energy cost of force production for a purely isometric contraction performed at the corresponding length (same length, same activation). Experiments were performed in skinned fibres isolated from rabbit psoas muscle. Skinned fibres were actively shortened from an average sarcomere length of 3.0 µm to an average sarcomere length of 2.4 µm. Purely isometric reference contractions were performed at an average sarcomere length of 2.4 µm. Simultaneously with the force measurements, the ATP cost was measured during the last 30 s of isometric contractions using an enzyme-coupled assay. Stiffness was calculated during a quick stretch-release cycle of 0.2% fibre length performed once the steady state had been reached after active shortening and during the purely isometric reference contractions. Force and stiffness following active shortening were decreased by 10.0±1.8% and 11.0±2.2%, respectively, compared with the isometric reference contractions. Similarly, ATPase activity per second (not normalized to the force) showed a decrease of 15.6±3.0% in the force-depressed state compared with the purely isometric reference state. However, ATPase activity per second per unit of force was similar for the isometric contractions following active shortening (28.7± 2.4 mmol l −1 mN -1 s mm 3 ) and the corresponding purely isometric reference contraction (30.9±2.8 mmol l −1 mN −1 s mm 3 ). Furthermore, the reduction in absolute ATPase activity per second was significantly correlated with force depression and stiffness depression. These results are in accordance with the idea that force depression following active shortening is primarily caused by a decrease in the proportion of attached cross-bridges. Furthermore, these findings, along with previously reported results showing a decrease in ATP consumption per unit of force after active muscle stretching, suggest that the mechanisms involved in the steady-state force after active muscle shortening and active muscle lengthening are of distinctly different origin.

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“…However, these muscle properties have been assessed predominantly using dissected muscles (e.g. Burke et al, 1976;Close, 1964;De Haan et al, 1989;Ettema et al, 1990;Meijer et al, 1998;Rack and Westbury, 1969), assuming implicitly that all muscle force is transmitted via its tendons to bone. In such a case, force at the proximal tendon should be equal to force at the distal tendon of that muscle.…”

Section: Introductionmentioning

confidence: 99%

Muscle force is determined also by muscle relative position: isolated effects

Maas

Baan

Huijing

2004

Journal of Biomechanics

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Effects on force of changes of the position of extensor digitorum longus muscle (EDL) relative to surrounding tissues were investigated in rat. Connective tissue at the muscle bellies of tibialis anterior (TA), extensor hallucis longus (EHL) and EDL was left intact, to allow myofascial force transmission. The position of EDL muscle was altered, without changing EDL muscle-tendon complex length, and force exerted at proximal and distal tendons of EDL as well as summed force exerted at the distal tendons of TA and EHL muscles (TA+EHL) were measured. Proximal and distal EDL forces as well as distal TA+EHL force changed significantly on repositioning EDL muscle.These muscle position-force characteristics were assessed at two EDL lengths and two TA+EHL lengths. It was shown that changes of muscle force with length changes of a muscle is the result of the length changes per se, as well as of changes of relative position of parts of the muscle. It is concluded that in addition to length, muscle position relative to its surroundings co-determines isometric muscle force. r

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A Hill type model of rat medial gastrocnemius muscle that accounts for shortening history effects

Cited by 60 publications

References 22 publications

New insights into force depression in skeletal muscle

New insights into force depression in skeletal muscle

Energy cost of isometric force production after active shortening in skinned muscle fibres

Muscle force is determined also by muscle relative position: isolated effects

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