A Hippocampal Lesion Detected by High-Field 3 Tesla Magnetic Resonance Imaging in a Patient with Temporal Lobe Epilepsy

Sawaishi, Yukio; Sasaki, Makoto; Yano, Tamami; Hirayama, Aya; Akabane, Jinzo; Takada, Goro

doi:10.1620/tjem.205.287

Cited by 20 publications

(14 citation statements)

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“…Of the 22 studies (15 %) that did provide some sensitivity and specificity information, 7 calculated accuracy on a per patient basis [17,[26][27][28][29][30][31], 9 calculated accuracy on a per lesion basis [32][33][34][35][36][37][38][39][40], 4 calculated both [16,[41][42][43] and in two studies, sensitivity and specificity were irrelevant [44,45], precluding a formal meta-analysis. We provide, instead, summaries of lesion detection, clinical relevance, and true and false positives and negatives (Table 3).…”

Section: Diagnostic Accuracymentioning

confidence: 99%

A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research

et al. 2012

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• Higher field strength MRI may improve image quality and diagnostic accuracy. • There are few direct comparisons of 1.5 and 3 T MRI. • Theoretical doubling of the signal-to-noise ratio in practice was only 25 %. • Objective evidence of improved routine clinical diagnosis is lacking. • Other aspects of technology improved images more than field strength.

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Section: Diagnostic Accuracymentioning

confidence: 99%

A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research

et al. 2012

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“…Although it comprises separate but interconnected cellular zones that differ in their susceptibility to pathologic processes ( 3 ), of particular recent interest is its approximately 100-m m-thick dentate granule cell layer (DGCL) that generates neuronal progenitor cells and is implicated in memory formation (4)(5)(6). Hippocampal damage has been linked to epilepsy ( 7,8 ), Alzheimer disease ( 9 ), mood disorders (10)(11)(12), and schizophrenia (13)(14)(15). Together these diseases affect more than 28 million people in the United States across the entire human life span from childhood to old age ( 16-19 ).…”

Section: Mr Imagingmentioning

confidence: 99%

Human Hippocampal Subfields in Young Adults at 7.0 T: Feasibility of Imaging

Prudent¹,

Kumar²,

Liu³

et al. 2010

Radiology

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Purpose:To establish an imaging approach to visualize the 100-m mthick hippocampal neuron-generating dentate granule cell layer (DGCL) consistently within a clinically feasible magnetic resonance (MR) imaging duration and to assess its sensitivity by quantifying the likelihood that it will be detected in healthy young adults. Materials and Methods:The study was HIPAA compliant and institutional review board approved. All subjects provided written informed consent. Ten healthy volunteers (fi ve male subjects, fi ve female subjects; mean age , 26 years 6 6 [standard deviation]) were imaged at 7.0 T by using a 24-element head coil array with three-dimensional T1-weighted MR imaging for anatomic reference, followed by T2*-weighted gradient-echo (echo time, 25 msec; repetition time, 944 msec) imaging at 232-m m in-plane resolution (0.05-mm 3 pixels) in coronal and sagittal slabs (17 sections at 1 mm thick) over the hippocampus in 14 minutes. The entire study took 45 minutes. Results:The DGCL was consistently visible in all 10 enrolled subjects. All larger subfi elds were visible in excellent detail and contrast in every subject. Conclusion:The spatial resolution and tissue contrast at high fi eld strength (7.0 T) MR imaging can be used to consistently reveal hippocampal morphology down to 100-m m subfi elds within a clinically acceptable imaging duration. This imaging technique might be used to detect cellular disarray and degenerative changes in this sensitive circuit earlier than at 1.5 T or even 3.0 T.q RSNA, 2010 1

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“…Due to its high resolution, 3-Tesla MRI (3T-MRI), as compared with conventional 1.5 Tesla-MRI (1.5T-MRI), may reveal precise findings in patients with neurodegenerative disease (13) and epilepsy (14)(15)(16). Recently, 3T-MRI with higher spatial resolution indicated partial loss of the internal structure in the abnormal hippocampus in MTLE patients (17).…”

Section: Introductionmentioning

confidence: 99%

Internal Structural Changes in the Hippocampus Observed on 3-Tesla MRI in Patients with Mesial Temporal Lobe Epilepsy

et al. 2013

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Objective Hippocampal sclerosis (HS) is observed in many intractable, mesial temporal lobe epilepsy (MTLE) patients. We aimed to delineate the internal structural changes (ISC) shown as loss of internal architecture in the hippocampus on 3-Tesla magnetic resonance imaging (3T-MRI) due to its higher spatial resolution. Methods We studied 12 MTLE patients who exhibited unilateral HS on conventional 1.5 Tesla-MRI. Using 3T-MRI, high resolution T2-weighted coronal images of the hippocampus were investigated by visual inspection without the use of detailed clinical information. In addition, tissue samples obtained from four patients who underwent epilepsy surgery were analyzed histopathologically. Results In addition to hippocampal atrophy (HA) in the abnormal side, blurring of the low-intensity streak, i.e., ISC, in the hippocampus was seen in 12 patients and atrophy or high signal intensity was observed in Ammon's horn or the dentate gyrus in nine patients. After four patients underwent epilepsy surgery, tissue samples showed astrogliosis and a loss of pyramidal neurons in the hippocampal body, concordant with ISC or HA on MRI examination. Conclusion High-resolution MRI suggests that minute internal structural changes in the hippocampus reflect neuronal cell loss or gliosis, possibly in the early stage, and also show laterality of changes more sensitively. Different internal structural changes could further subclassify HS and may predict the surgical outcomes of seizure control based on the clinicopathological correlation.

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A Hippocampal Lesion Detected by High-Field 3 Tesla Magnetic Resonance Imaging in a Patient with Temporal Lobe Epilepsy

Cited by 20 publications

References 13 publications

A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research

A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research

Human Hippocampal Subfields in Young Adults at 7.0 T: Feasibility of Imaging

Internal Structural Changes in the Hippocampus Observed on 3-Tesla MRI in Patients with Mesial Temporal Lobe Epilepsy

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