A Histochemical and Immunohistochemical Study of Certain Defense Mechanisms in the Human Lacrimal Sac Epithelium.

Perra, Maria Teresa; Serra, A.; Sirigu, P.; Turno, F.

doi:10.1679/aohc.58.517

Cited by 26 publications

(18 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The flow of tears carries foreign materials and antigens into the lacrimal drainage system where the lacrimal sac mucosa has a variety of anti-infection strategies to prevent colonization by microorganisms 1–7. The first line of defense against invading pathogens is the lacrimal sac epithelium 2,8. The epithelial cells covering the inner surface are tightly bound together by junctional complexes and protect the underlying tissues from viral or bacterial invasion.…”

Section: Introductionmentioning

confidence: 99%

“…The epithelial cells covering the inner surface are tightly bound together by junctional complexes and protect the underlying tissues from viral or bacterial invasion. The epithelial cells secrete IgA,2 anti-infection peptides,6 and mucins 7. Many pathological conditions can cause structural changes in the mucosa, including hyperplasia of the goblet cells 8.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Structural changes in the lacrimal sac epithelium and associated lymphoid tissue during experimental dacryocystitis

Ishikawa¹,

Kubo

Maeda

et al. 2011

OPTH

View full text Add to dashboard Cite

PurposeTo examine structural changes in the lacrimal sac epithelium and associated lymphoid tissue of rabbits with experimentally induced dacryocystitis.MethodsExperimental dacryocystitis was induced by an inoculation of Staphylococcus aureus into the lacrimal sac. The histological changes of the inflamed lacrimal sac epithelium and associated lymphoid tissue were studied by light and electron microscopy.ResultsAfter 1 month, numerous inflammatory cells (CD20-positive B lymphocytes, CD3-positive T lymphocytes, IgA-positive plasma cells, and polymorphonuclear leukocytes) infiltrated the lamina propria and the epithelium overlying the diffuse lymphoid tissue. Three months later, the density of the infiltrated leukocytes was markedly decreased. The epithelial lining overlying the diffuse lymphoid tissue became thicker with numerous secretory granules in the supranuclear regions.ConclusionThe lacrimal sac epithelium and associated lymphoid tissue play a major role in the defense mechanism during inflammation. Overproduction of secretory granules after bacterial inoculation could enhance the antimicrobial defense.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural changes in the lacrimal sac epithelium and associated lymphoid tissue during experimental dacryocystitis

Ishikawa¹,

Kubo

Maeda

et al. 2011

OPTH

View full text Add to dashboard Cite

show abstract

“…Tear flow through the lacrimal sac and nasolacrimal duct is highly dependent on interactions between mucosal mucins, microvilli, and tear fluid. (13)(14)(15) The lacrimal sac and nasolacrimal duct have a different pattern of mucin gene expression compared to the ocular surface. Immunohistochemistry shows that the epithelium of the lacrimal sac and nasolacrimal duct produces MUC5B and -7 and, to a lesser degree, MUC5AC and -2.…”

Section: Discussionmentioning

confidence: 99%

“…The nasolacrimal duct was found to produce MUC5B. (13)(14)(15) The diversity of mucins in the lacrimal sac and nasolacrimal duct may be related to improved tear transportation and antimicrobial effects. The reduced levels of mRNA for secretory mucins found in functional dacryostenosis supports the hypothesis that mucins facilitate tear flow through the nasolacrimal duct.…”

Section: Discussionmentioning

confidence: 99%

“…The reduced levels of mRNA for secretory mucins found in functional dacryostenosis supports the hypothesis that mucins facilitate tear flow through the nasolacrimal duct. (13)(14)(15) The Na+/I-symporter (NIS) is a glycoprotein that promotes iodide uptake by the thyroid gland and several other tissues. Nasolacrimal duct obstruction has been reported as complication of radioiodine (I-131) therapy in the treatment of thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lacrimal duct obstruction after radioiodine therapy: case report and treatment

Lorena¹,

Silva²

2014

Revista Brasileira De Oftalmologia

View full text Add to dashboard Cite

CASE REPORTRev Bras Oftalmol. 2014; 73 (3): 185-7 RESUMOIodoterapia representa a terapia com iodo radioativo. A radiação beta emitida pelo iodo radioativo são partículas que irão se armazenar no tecido da tireóide destruindo as células cancerígenas que ainda restaram após a cirurgia (tireoidectomia). É importante enfatizar este possível efeito deletério da terapêutica, a qual afeta a mucosa da via lacrimal, sendo o resultado do processo de inflamação e cicatrização vascular, produzindo transtornos hipovasculares, hipocelulares e hipóxicos.Descritores: Obstrução dos ductos lacrimais/etiologia; Dacriocistite; Radioisótopos do iodo/efeitos adversos; Relatos de casos ABSTRACT Iodotherapy represents the radioactive iodine therapy. The beta radiation emitted by radioactive iodine are particles that will be stored in the thyroid tissue destroying cancer cells that were left after surgery (thyroidectomy). It is important to emphasize a possible deleterious effect of therapy which affects the mucosa of the lacrimal system which results in a process of vascular inflammation and scarring producing disorders hypovascular, hypocellular and hypoxic.

show abstract