A histochemical and immunohistological study of a testicular malignant teratoma containing embryonic and extraembryonic elements in various stages of development

The presence of human chorionic gonadotrophin (HCG) in colorectal adenocarcinoma was studied histologically in 45 tumors using immunoperoxidase technique. Ten neoplasms (22.2 percent) contained HCG-positive tumor cells. These cells were present mostly at the periphery of the tumors. Many formed parts of glands, while some were arranged in syncytial clumps or columns, or singularly. Thus, these tumor cells resembled trophoblastic tissue not only in being HCG-positive but also in their peripheral distribution and occasionally in morphologic appearance. HCG-positive tumors were seen more commonly in the rectosigmoid region (90 percent) and were more aggressive than HCG-negative tumors. In this study, lymph node or liver metastases were present in 70 percent of HCG-positive tumors compared with 29 percent of negative tumors--a difference which is statistically significant.

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Human chorionic gonadotrophin expression in colorectal adenocarcinoma

Shousha

Chappell

Matthews

et al. 1986

Diseases of the Colon &Amp; Rectum

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Differential Labeling by Monoclonal Antibodies Adnab-9 and Anti-?-Defensin 5 Based on the Distribution and Adenomatous Tissue Content of Colonic Polyps

et al. 2005

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We sought a correlation between site and morphology of colonic polyps by labeling with neoplastic and general Paneth cell markers, monoclonal antibodies Adnab-9 and anti-alpha-defensin 5, respectively. Proportions labeled by Adnab-9 and anti-alpha-defensin 5 were, respectively, 42 and 85% for adenomas, 39 and 63% for early tubular adenomas, 41 and 44% for serrated, 34 and 20% for mixed, and 11 versus 2.7% for hyperplastic polyps. Compared with hyperplastic polyps, the proportion of other polyps labeled by Adnab-9 or anti-alpha-defensin 5 was higher but this difference was more significant for distal (P = 0.008 for Adnab-9 and P = 0.0001 for anti-alpha-defensin 5) than proximal (P = 0.645 and P = 0.154, respectively) polyps. While increased labeling of all proximal polyps compared to distal ones mirrored the colonic distribution of Paneth cells, distal adenomas tended to have a higher proportion labeled by Adnab-9, suggesting that Adnab-9 labels Paneth cells associated with increased neoplastic potential.

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Rupture of a benign mediastinal teratoma into the right pleural cavity

Hiraiwa

Hayashi

Kaneda

et al. 1991

The Annals of Thoracic Surgery

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A histochemical and immunohistological study of a testicular malignant teratoma containing embryonic and extraembryonic elements in various stages of development

Cited by 4 publications

References 22 publications

Human chorionic gonadotrophin expression in colorectal adenocarcinoma

Human chorionic gonadotrophin expression in colorectal adenocarcinoma

Differential Labeling by Monoclonal Antibodies Adnab-9 and Anti-?-Defensin 5 Based on the Distribution and Adenomatous Tissue Content of Colonic Polyps

Rupture of a benign mediastinal teratoma into the right pleural cavity

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