A histologic comparison of effects of electrosurgical resection using different electrodes

Noble, Warden H.; McClatchey, Kenneth D.; Douglass, Gordon D.

doi:10.1016/0022-3913(76)90054-8

Cited by 27 publications

(15 citation statements)

References 7 publications

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“…These observations are in contrast to other findings, i.e. that electrosurgical incision is noninjurious at the cellular level [7,8]. …”

Section: Introductioncontrasting

confidence: 56%

“…While extensive areas of carbonization and epithelial distortion at the margins of excision have occasionally been found (<50 microns) in specimens obtained by the electrosurgical excision, the changes have not affected the evaluation of the epithelium and stroma both histologically and cytologically [29]. Other authors consider that electrosurgical incision is noninjurious at cellular level whereas no such damage has been noted in SC incision [7,8]. …”

Section: Discussionmentioning

confidence: 99%

“…The thermal changes are considered to include an average necrosis of 0.12- to 0.26-mm width causing coagulation necrosis of both epithelium and connective tissue [7,8]. These changes at the tissue margin can very well be expected to affect the results of TIC.…”

Section: Discussionmentioning

confidence: 99%

“…Its use is increasingly showing promising results [22,23,24,25,26,27,28], with recent use in oral carcinomas being found to be an effective intraoperative technique [2]. However, the effect of confounding factors like mode of excision [7,8,9,29] and method of staining [16,17,18] on the results of TIC still need to be examined.…”

Section: Introductionmentioning

confidence: 99%

“…Excellent hemostatic control, a clean surgical field, increased surgeon efficiency, reduced postoperative swelling and only a mild inflammatory response [3,7] are well-known advantages of electrocautery (EC) over scalpel (SC) for excision. However, the deleterious thermal changes of EC cannot be overlooked [5,6] and opinion remains divided regarding its effect at the histological and cellular level [3,5,6,7,8]. Some consider that EC may cause extensive thermal damage to the specimen with resultant artifacts severely limiting the assessment of the margins of excision [9].…”

Section: Introductionmentioning

confidence: 99%

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Confounding Factors and Diagnostic Accuracy of Imprint Cytology

Yadav¹,

Donoghue²,

Tauro

et al. 2013

Acta Cytologica

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Background: Eradication of malignant tumors at the primary site with oncological safe margin is a critical requirement for obtaining better survival rate and less recurrence. Touch imprint cytology (TIC) has proven itself as a quick, simple, inexpensive, highly accurate and reliable intraoperative technique to assess surgical margins in squamous cell carcinomas of the oral cavity. However, it is still unclear how the mode of excision, i.e. by scalpel (SC) and electrocautery (EC), or the method of staining, i.e. Papanicolaou (PAP) and cytohaem, affect the diagnostic accuracy of TIC. Objective: To study the influence of confounding factors like mode of excision (EC/SC) and staining (PAP/cytohaem) on the diagnostic accuracy of intraoperative TIC technique for assessing surgical margins in oral squamous cell carcinoma in comparison to paraffin-embedded HE-stained sections. Materials and Methods: Thirty patients underwent surgical treatment for primary oral squamous cell carcinoma. Three hundred and forty-eight touch imprint slides were prepared from 174 margins of 30 resected tumor specimens. Two adjacent tissues from the margin to be evaluated were imprinted to observe differences between surfaces excised by EC and SC. The set of imprint from each margin tissue was stained with PAP and cytohaem. The TIC results of 180 EC-excised margins and 168 SC-excised margins were compared. Results of 174 imprints stained with RAPID-PAP were compared to their counterpart comprising of 174 cytohaem-stained imprints. The slides were diagnosed as positive, negative or suspicious for tumor. Finally, TIC results were checked against their respective histopathological sections. Results: No statistically significant difference was found between the results of imprints from EC/SC-excised margins (Z = 0.44, p = 0.70) or the imprints stained with PAP/cytohaem (Z = 0.44, p = 0.70). Conclusion: Confounding factors like mode of excision and staining procedure do not significantly influence the results of imprint cytology.

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“…These observations are in contrast to other findings, i.e. that electrosurgical incision is noninjurious at the cellular level [7,8]. …”

Section: Introductioncontrasting

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Confounding Factors and Diagnostic Accuracy of Imprint Cytology

Yadav¹,

Donoghue²,

Tauro

et al. 2013

Acta Cytologica

View full text Add to dashboard Cite

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Preclinical evaluation of porcine colon resection using hollow core negative curvature fibre delivered ultrafast laser pulses

Mohanan

Beck

West

et al. 2019

Journal of Biophotonics

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Ultrashort pulse lasers offer great promise for tissue resection with exceptional precision and minimal thermal damage. Surgery in the bowel requires high precision and minimal necrotic tissue to avoid severe complications such as perforation. The deployment of ultrashort lasers in minimally invasive or endoscopic procedures has been hindered by the lack of suitable optical fibres for high peak powers. However, recent developments of hollow core microstructured fibres provide potential for delivery of such pulses throughout the body. In this study, analysis of laser ablation via a scanning galvanometer on a porcine colon tissue model is presented. A thermally damaged region (<85 μm) and fine depth control of ablation using the pulse energies 46 and 33 μJ are demonstrated. It is further demonstrated that such pulses suitable for precision porcine colon resection can be flexibly delivered via a hollow core negative curvature fibre (HC-NCF) and again ablation depth can be controlled with a thermally damaged region <85 μm. Ablation volumes are comparable to that of early stage lesions in the inner lining of the colon. This study concludes that the combination of ultrashort pulses and flexible fibre delivery via HC-NCF present a viable route to new minimally invasive surgical procedures. K E Y W O R D S negative curvature fibre, plasma-mediated ablation, porcine colon, thermal necrosis, ultrafast laser surgery

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