A Histological Study of Lymphoid Neoplasms in Cattle Infected with Bovine Leukosis Virus

Hagiwara, Akiyo; Saito, Morihiro; Ishikawa, Yoshiharu; Kadota, Koichi

doi:10.12935/jvma.67.199

Cited by 6 publications

(14 citation statements)

References 11 publications

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“…Large and pleomorphic cells including cells with prominent nucleoli are observed in the pleomorphic variant of human mantle cell lymphoma (Swerdlow et al 2008). In contrast, the current cases showed histological transition from neoplastic mantle cells to larger and more pleomorphic cells, and the latter morphologically corresponded to pleomorphic B cell lymphoma cells (Murayama et al 2011, Iwama et al 2013, Hagiwara et al 2014. Lymph nodes composed chiefly of neoplastic pleomorphic cells showed a tendency toward severe enlargement in case 1, and thus were considered to be in the later stages of tumor development.…”

Section: Discussionmentioning

confidence: 54%

“…Some cases are macroscopically characterized by abdominal tumor masses and considered to be derived from B-1 cells in the abdominal cavity (Abe et al 2007, Hagiwara et al 2014. The current study reports two cases of CD5-and cyclin D1-positive nodal mantle cell lymphoma where histological progression to pleomorphic B cell lymphoma was observed.…”

Section: Introductionmentioning

confidence: 60%

“…A case of B-immunoblastic lymphoma evolving from a mantle cell lymphoma has been reported in humans, but the transition of mantle cell lymphoma to centroblastic lymphoma (diffuse cell) has not (Feller & Diebold 2004). The presence of cIg may be observed in follicular or follicle center cell lymphomas and more mature cells in cattle and swine (Kadota & Niibori 1985, Kadota et al 1986, Kadota & Nakajima 1988, Kameyama et al 2003, Honda et al 2009, Murayama et al 2011, Nishijo et al 2013, Hagiwara et al 2014. The absence of cIg in human and bovine mantle cell lymphomas can be explained by the fact that mantle cells correspond to naive pre-germinal center B cells (Feller & Diebold 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Most BLV-associated lymphomas are classified as pleomorphic B cell lymphomas (Iwama et al 2013, Hagiwara et al 2014. On the basis of cytological atypia and pleomorphism in some areas, the current cases were judged to be associated with the virus (Iwama et al 2013).…”

Section: Discussionmentioning

confidence: 99%

“…In cattle, most lymphomas associated with bovine leukemia virus (BLV) are characterized by cytological pleomorphism and atypia, and are designated pleomorphic B cell lymphomas (Kagawa et al 2009, Murayama et al 2011, Iwama et al 2013, Hagiwara et al 2014. Some cases are macroscopically characterized by abdominal tumor masses and considered to be derived from B-1 cells in the abdominal cavity (Abe et al 2007, Hagiwara et al 2014.…”

Section: Introductionmentioning

confidence: 99%

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Mantle Cell Lymphoma with Histological Progression to Pleomorphic Lymphoma in Two Cattle

Hagiwara

Saito

Ishikawa

et al. 2018

JARQ

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An abattoir survey for bovine enzootic leukosis revealed that severe splenomegaly and hepatomegaly were observed in a heifer (case 1) and a steer (case 2), respectively, in addition to great enlargement of certain lymph nodes. Both cases tested positive for bovine leukemia virus (BLV) by polymerase chain reaction. Histologically, the neoplastic tissues in case 1 were characterized by a mantle zone growth pattern of medium-sized cells showing a transition to highly pleomorphic and atypical cells. Similar histological characteristics were also observed in case 2, but neoplastic mantle cells forming focal lesions were more pleomorphic than in case 1. B cell markers CD20 and CD79a were expressed in cases 1 and 2, as well as CD5 and cyclin D1, which are important markers for human mantle cell lymphoma. Cases of pleomorphic B cell lymphoma with large abdominal tumor masses are thought to be derived from body cavity B-1 cells, whereas this study suggests that nodal pleomorphic B cell lymphoma is of mantle cell origin.

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Section: Discussionmentioning

confidence: 54%

Section: Introductionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Mantle Cell Lymphoma with Histological Progression to Pleomorphic Lymphoma in Two Cattle

Hagiwara

Saito

Ishikawa

et al. 2018

JARQ

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Disseminated thymic B-cell lymphoma in a Holstein heifer

et al. 2019

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A 19-mo-old Holstein heifer was inactive and dyspneic. Physical examination revealed wheezing, exophthalmos, a cervical mass, and lymphadenopathy. Cytology of the cervical mass and lymph nodes showed predominantly large atypical lymphocytes. Lactate dehydrogenase and thymidine kinase activities were elevated. Although nested PCR for bovine leukemia virus (BLV) using blood was positive, quantitative PCR showed a low number of provirus copies. Autopsy revealed enlargement of most lymph nodes examined, as well as white masses of various sizes in muscles of the left hindlimb and thoracic and abdominal organs. Histopathology revealed severe infiltration with neoplastic lymphocytes in these organs. The cervical mass was immune-positive for B-cell markers. The final diagnosis was thymic B-cell lymphoma with BLV infection.

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Immature T cell neoplasms in three young cattle

R¹,

Sato²,

Wada

et al. 2015

The Journal of Veterinary Medical Science

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Immature T cell neoplasms in three young Holstein cattle with neoplastic involvement of the thymus are described. Case 1, with a precursor T lymphoblastic leukemia (calf form of leukosis), was an 86-day-old female calf. The leukemia was characterized by replacement of the bone marrow and spleen by leukemia cells, but preservation of epithelial frameworks throughout the thymus. The other two neoplasms were thymic γδ T cell lymphomas, which were observed in a 246-day-old steer (case 2) and a 16-month-old heifer (case 3). Histological examination revealed obliteration of the normal thymic architecture and stromal fibrosis, with the spleen and liver far less severely affected than in case 1. There were cytological differences bewteen the tumors in case 1 and cases 2 and 3. Additionally, WC1 and CD8 were expressed only in the latter. Thus, the leukemia and these lymphomas should be regarded as independent disease entities on the basis of histological and immunohistochemical characteristics.

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A Histological Study of Lymphoid Neoplasms in Cattle Infected with Bovine Leukosis Virus

Cited by 6 publications

References 11 publications

Mantle Cell Lymphoma with Histological Progression to Pleomorphic Lymphoma in Two Cattle

Mantle Cell Lymphoma with Histological Progression to Pleomorphic Lymphoma in Two Cattle

Disseminated thymic B-cell lymphoma in a Holstein heifer

Immature T cell neoplasms in three young cattle

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