A histone deacetylase, GhHDT4D, is positively involved in cotton response to drought stress

Zhang, Jingbo; He, Shao-Ping; Luo, Jingwen; Wang, Xinpeng; Li, Deng-Di; Li, Xuebao

doi:10.1007/s11103-020-01024-9

Cited by 18 publications

(12 citation statements)

References 47 publications

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“…The overexpression of the Brachypodium histone deacetylase BdHD1 results in hypersensitivity to ABA and enhanced drought resistance [46]. The overexpression of the cotton histone deacetylase GhHDT4D in Arabidopsis increases plant tolerance to drought [47]. In this study, we analyzed the expression changes of all TaHATs and TaHDACs under drought stress in different drought-resistant wheat varieties.…”

Section: Expression Level Of Tahats and Tahdacs Under Drought Stressmentioning

confidence: 99%

Comparative Genome-Wide Analysis and Expression Profiling of Histone Acetyltransferases and Histone Deacetylases Involved in the Response to Drought in Wheat

Liu

Pei

et al. 2021

J Plant Growth Regul

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Background: Histone acetyltransferases (HATs) and histone deacetylases (HDACs) contribute to plant growth, development, and stress responses. A number of HAT and HDAC genes have been identi ed in several plants. However, wheat HATs and HDACs have not been comprehensively characterized. In this study, we identi ed TaHATs and TaHDACs in the wheat genome using bioinformatics tools.Result: In total, 30 TaHAT genes and 53 TaHDAC genes were detected in the wheat genome. As described in other plants, TaHATs were classi ed into four subfamilies (i.e., GNAT, p300/CBP, MYST, and TAFII250) and TaHDACs were divided into three subfamilies (i.e., RPD3/HDA1, HD2, and SIR2). Phylogenetic and conserved domain analyses showed that TaHATs and TaHDACs are highly similar to those in Arabidopsis and rice; however, divergence and expansion from Arabidopsis and rice were also observed. We detected many stress-related cis-regulatory elements in the promoter regions of these genes (i.e., ABRE, STRE, MYB et al.). Further, based on a comparative expression analyses of three varieties with different degrees of drought resistance under drought stress, we found that TaHAG2, TaHAG3, TaHAC2, TaHDA18, TaHDT1, and TaHDT2 are likely regulate drought stress in wheat.Conclusions: In this study, TaHATs and TaHDACs from the wheat genome were identi ed. Three TaHATs and three TaHDACs were very likely to regulate drought stress based on a promoter analysis and gene expression analysis. These results provide a foundation for further research on the regulation of acetylation in wheat and its role in the response to drought stress.

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Section: Expression Level Of Tahats and Tahdacs Under Drought Stressmentioning

confidence: 99%

Comparative Genome-Wide Analysis and Expression Profiling of Histone Acetyltransferases and Histone Deacetylases Involved in the Response to Drought in Wheat

Liu

Pei

et al. 2021

J Plant Growth Regul

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“…In addition, some studies revealed a direct correlation between stress‐induced differences in gene transcript expression and the level of H3K9ac histone modifications through integrative analysis, identifying epigenetic targets affecting drought stress response, developmental and metabolic pathways in maize (Forestan et al 2018). Zhang also found that GhHDT4D , a member of the HD2 subfamily of HDAC, might enhance drought tolerance by repressing GhWRKY33 expression, thereby activating downstream drought‐responsive genes and thus enhancing drought resistance in cotton (Zhang et al 2020a). The present study also identified H3K9ac‐related differential genes and predicted their functions in sea buckthorn, which will lay an important foundation for the in‐depth analysis of the regulatory mechanism of histone acetylation in drought resistance.…”

Section: Discussionmentioning

confidence: 99%

Histone H3K9 acetylation modulates gene expression of key enzymes in the flavonoid and abscisic acid pathways and enhances drought resistance of sea buckthorn

Li,

Wei,

Song

et al. 2023

Physiologia Plantarum

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The effect of histone H3K9 acetylation modification on gene expression and drought resistance in drought‐resistant tree species is not clear. Using the chromatin immunoprecipitation (ChIP) method, this study obtained nine H3K9 acetylated protein‐interacting DNAs from sea buckthorn seedlings, and the ChIP sequencing result predicted about 56,591, 2217 and 5119 enriched region peaks in the control, drought and rehydration comparative groups, respectively. Gene functional analysis of differential peaks from three comparison groups revealed that 105 pathways were involved in the drought resistance process, and 474 genes were enriched in the plant hormone signaling transduction pathways. Combined ChIP‐seq and transcriptome analysis revealed that six genes related to abscisic acid synthesis and signaling pathways, 17 genes involved in flavonoid biosynthesis, and 15 genes involved in carotenoid biosynthesis were positively regulated by H3K9 acetylation modification under drought stress. Under drought stress conditions, the content of abscisic acid and the expression of related genes were significantly up‐regulated, while the content of flavonoids and the expression of key enzymes involved in their synthesis were largely down‐regulated. Meanwhile, after exposure to histone deacetylase inhibitors (trichostatin A), the change of abscisic acid and flavonoids content and their related gene expression were slowed down under drought stress. This study will provide an important theoretical basis for understanding the regulatory mechanisms of histone acetylation modifications in sea buckthorn drought resistance.

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“…Histone acetylation is dynamically modulated by HATs and HDACs and plays a key role in maintaining the structural stability of chromatin and gene expression in response to developmental and environmental stimuli (Kumar et al, 2021). HDACs have been reported to play crucial roles in modulating gene expression in abiotic stress responses (Song and Galbraith, 2006; Zheng et al, 2016; Liu et al, 2020; Zhang et al, 2020). AtHDA19, AtHDA6, and AtSRT2 (SIRTUIN 2) can deacetylate H3K9, H4K12, H3K14, and H4K8 (Benhamed et al, 2006; Earley et al, 2006; Tang et al, 2022); HDA710 can deacetylate H4K5, H4K16, and H4K8; and HDA703 can deacetylate H4K12 and H4K8 (Ullah et al, 2020; Wang et al, 2020a).…”

Section: Discussionmentioning

confidence: 99%

OsWR2 recruits HDA704 to regulate the deacetylation of H4K8ac in the promoter of OsABI5 in response to drought stress

Guo

Tan

et al. 2023

JIPB

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Drought stress is a major environmental factor that limits the growth, development, and yield of rice (Oryza sativa L.). Histone deacetylases (HDACs) are involved in the regulation of drought stress responses. HDA704 is an RPD3/HDA1 class HDAC that mediates the deacetylation of H4K8 (lysine 8 of histone H4) for drought tolerance in rice. In this study, we show that plants overexpressing HDA704 (HDA704-OE) are resistant to drought stress and sensitive to abscisic acid (ABA), whereas HDA704 knockout mutant (hda704) plants displayed decreased drought tolerance and ABA sensitivity. Transcriptome analysis revealed that HDA704 regulates the expression of ABA-related genes in response to drought stress. Moreover, HDA704 was recruited by a drought-resistant transcription factor, WAX SYNTHESIS REGULATORY 2 (OsWR2), and co-regulated the expression of the ABA biosynthesis genes NINE-CIS-EPOXYCAROTENOID DIOX-YGENASE 3 (NCED3), NCED4, and NCED5 under drought stress. HDA704 also repressed the expression of ABA-INSENSITIVE 5 (OsABI5) and DWARF AND SMALL SEED 1 (OsDSS1) by regulating H4K8ac levels in the promoter regions in response to polyethylene glycol 6000 treatment. In agreement, the loss of OsABI5 function increased resistance to dehydration stress in rice. Our results demonstrate that HDA704 is a positive regulator of the drought stress response and offers avenues for improving drought resistance in rice.

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A histone deacetylase, GhHDT4D, is positively involved in cotton response to drought stress

Cited by 18 publications

References 47 publications

Comparative Genome-Wide Analysis and Expression Profiling of Histone Acetyltransferases and Histone Deacetylases Involved in the Response to Drought in Wheat

Comparative Genome-Wide Analysis and Expression Profiling of Histone Acetyltransferases and Histone Deacetylases Involved in the Response to Drought in Wheat

Histone H3K9 acetylation modulates gene expression of key enzymes in the flavonoid and abscisic acid pathways and enhances drought resistance of sea buckthorn

OsWR2 recruits HDA704 to regulate the deacetylation of H4K8ac in the promoter of OsABI5 in response to drought stress

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