A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant

Waldron, Charles A.; El‐Mofty, Samir K.

doi:10.1016/0030-4220(87)90257-x

Cited by 185 publications

(162 citation statements)

References 13 publications

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“…Similarly to desmoplastic ameloblastomas, the hybrid lesions are rare, making up between 1.1% 10 and 4.5% of all the ameloblastomas 13 . Cases have been seen in men and women between 25 and 82 years 10,13,17,23,24 .…”

Section: Hybrid Lesionmentioning

confidence: 99%

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Ameloblastomas sólidos: estudo retrospectivo clínico e histopatológico em 54 casos

Fulco¹,

Nonaka²,

Souza³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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Recent ly, the World Health Organization (WHO) excluded the desmoplastic pattern from the histopathological spectrum of solid ameloblastomas and classified it as a distinct variant, named desmoplastic ameloblastoma. Aim: To perform a retrospective analysis of the clinicopathologic aspects in a case series of solid ameloblastomas. Study design: Crosssectional cohort study. Materials and methods: Data regarding age, gender, location and clinical characteristics were retrieved from patient records. Histological sections were evaluated regarding existing histological patterns and the predominant histological pattern. Cases were classified according to the study of Waldron and El-Mofty (1987) and the WHO classification of 2005. Results: A total of 54 cases were identified, with similar gender distribution and a mean age of 38.3 years. Fifty three cases (98.1%) affected the mandible. Forty nine cases (90.8%) were classified as solid ameloblastomas, 3 (5.6%) as desmoplastic ameloblastomas, and 2 (3.7%) as hybrid lesions. The most frequent histological patterns in solid ameloblastomas were follicular (77.6%), acanthomatous (69.4%), and plexiform (65.3%). Focal areas of desmoplastic ameloblastomas were identified in 11 solid ameloblastomas (22.4%). Conclusion: Despite its characterization as a distinct variant, our results revealed that focal areas of desmoplastic ameloblastomas can be observed with some frequency in conventional ameloblastomas.

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Section: Hybrid Lesionmentioning

confidence: 99%

“…Histological sections were evaluated regarding existing histological patterns and the predominant histological pattern. Cases were classified according to the study of Waldron and El-Mofty (1987) and the WHO classification of 2005. Results: A total of 54 cases were identified, with similar gender distribution and a mean age of 38.3 years.…”

mentioning

confidence: 99%

Ameloblastomas sólidos: estudo retrospectivo clínico e histopatológico em 54 casos

Fulco¹,

Nonaka²,

Souza³

et al. 2010

Braz. j. otorhinolaryngol. (Impr.)

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“…This occurs in 1% -5% of cases [15,16]. The cells are large, round, or polyhedral, and densely packed with eosinophilic granules and frequently demonstrate well-defined borders but, in some instances, form a syncytium.…”

Section: Discussionmentioning

confidence: 99%

Granular Cell Ameloblastoma: A Case Report and Literature Review

Kattimani

2015

J Dent Probl Solut

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The purpose of this case report is to compare the clinical and histopathologic features of granular cell ameloblastoma with critical review on literature. Data with respect to the histologic types regarding tumor with higher recurrence rates are also investigated. Numerous cases of ameloblastoma have been reported in the literature. However, only a few articles discuss granular cell ameloblastoma and few closely examine their nature and pathogenesis. In this case report, we analyzed the clinical and histopathologic features of granular cell ameloblastoma. a very coarse, granular eosinophilic appearance. Granular cell variety of ameloblastoma appears to be an aggressive lesion with a marked proclivity for recurrence. In addition, several cases of this type have been reported as metastasizing. The lesion have been shown to recur, particularly following inadequate surgical treatment [10]. Case ReportA female patient aged 34 yrs complains of swelling of left side gingiva in the region of canine and premolar since 1 yr. Which was smaller in size and gradually grown to present size, with difficulty in chewing as the growth is interfering in occlusion. On examination the sessile growth originated from left side of gingiva both lingually and buccally in relation to premolars. Which was approximately of 3×4 cm in size and superiorly above the occlusal plane and inferiorly the buccal vestibule. The lesion extends anteriorly from canine and posteriorly till mesial aspect of first molar. It was non tender and no lymphadenopathy felt. After routine blood investigations the patient posted for excisional biopsy. Under general anesthesia peripheral osteotomy performed and specimen sent for histopathology diagnosis.Histopathological report of excisional biopsy taken from right buccal vestibule in relation to 45 & 46 region revealed islands of ameloblastic epithelium in a fibrous connective tissue stroma. The centre of the island shows granular cells with eosinophilic granular cytoplasm and central nucleus. These features are suggestive of granular cell variant of ameloblastoma. DiscussionThe granular cell ameloblastoma is characterized by the presence of large masses of granular cells located within the follicles ( Figure 1). This occurs in 1% -5% of cases [15,16]. The cells are large, round, or polyhedral, and densely packed with eosinophilic granules and frequently demonstrate well-defined borders but, in some instances, form a syncytium. The nuclei are generally pyknotic and eccentrically displaced (Figures 2 and 3). The cells replace all or part of the stellate reticulum and, quite often the peripheral cells as well [15,17]. The granular cells are periodic acid-Schiff-positive and diastase resistant [18]. In our case much similar histopathologic finding of granular cell variant seen clearly.

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“…(7) When the maxillary sinus and surrounding structures are involved, opacification of the sinus and expansion of its walls with or without bone destruction makes it impossible to distinguish ameloblastoma from other malignant and invasive tumours. (8) A number of modalities have been proposed in the treatment of ameloblastoma, like wide excision, curettage, enucleation, cryotherapy, cautery, laser usage, radiotherapy and chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Huge Ameloblastoma Arising From Maxilla: Diagnosis and Management: A Case Report

Gautam¹,

Singh²,

Kanaujia³

et al. 2015

jemds

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ABSTRACT:Ameloblastoma is an odontogenic tumor of epithelial origin that has received considerable attention due to its frequency, clinical subtypes and high tendency to infiltrate and recur. Their name implies a resemblance to cells of enamel forming origin. This paper reports an unicystic large ameloblastoma arises from left maxillary region involving, nasal cavity and orbit. Microscopically tumour showing mixed plexiform and follicular pattern with superimposed infection. The patient was treated with total maxillectomy with prosthesis reconstruction.

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A histopathologic study of 116 ameloblastomas with special reference to the desmoplastic variant

Cited by 185 publications

References 13 publications

Ameloblastomas sólidos: estudo retrospectivo clínico e histopatológico em 54 casos

Ameloblastomas sólidos: estudo retrospectivo clínico e histopatológico em 54 casos

Granular Cell Ameloblastoma: A Case Report and Literature Review

Huge Ameloblastoma Arising From Maxilla: Diagnosis and Management: A Case Report

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