A histopathological analysis of spontaneous neoplastic and non-neoplastic          lesions in aged male RccHan:WIST rats

Hojo, Motoki; Sakamoto, Yoshimitsu; Maeno, Ai; Tayama, Kuniaki; Tada, Yasunori; Yuzawa, Katsuhiro; Ando, Hiroshi; Kubo, Yoshikazu; Nagasawa, Akemichi; Tanaka, Kazuyoshi; Yano, Norio; Kaihoko, Fujifumi; Hasegawa, Yūko; Suzuki, Tomohiko; Inomata, Akiko; Moriyasu, Takako; Miyajima, Katsuhiro; Nakae, Dai

doi:10.1293/tox.2019-0064

Cited by 6 publications

(4 citation statements)

References 19 publications

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“…However, we believe that there are more fundamental factors to be considered as carcinogenic risks when looking at the steady global increase in the fraction of cancer as a major cause of human mortality where major infective diseases have been overcome. Furthermore, laboratory mice and rats suffer from a high incidence of cancer in old age [ 19 , 20 , 21 ] even if they are usually not exposed to apparent carcinogens or cancer-risk factors. Based on these facts, we started to consider the significance of the origin and evolution of life in carcinogenesis.…”

Section: What Is the Major Cause Of Carcinogenesis In Humans?mentioning

confidence: 99%

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering

Toyokuni

Kong

Cheng

et al. 2020

Cancers

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Evolution from the first life on earth to humans took ~3.8 billion years. During the time there have been countless struggles among the species. Mycobacterium tuberculosis was the last major uncontrollable species against the human public health worldwide. After the victory with antibiotics, cancer has become the leading cause of death since 1981 in Japan. Considering that life inevitably depends on ceaseless electron transfers through iron and oxygen, we believe that carcinogenesis is intrinsically unavoidable side effects of using iron and oxygen. Many animal models unequivocally revealed that excess iron is a risk for carcinogenesis. This is supported by a variety of human epidemiological data on cancer risk and prognosis. Cancer is basically a disease of the genome with persistently activated oncogenes and inactivated tumor suppressor genes through which iron addiction with ferroptosis-resistance is maintained. Engineering has made a great advance in the past 50 years. In particular, nanotechnology is distinct in that the size of the engineered molecules is similar to that of our biomolecules. While some nano-molecules are found carcinogenic, there are principles to avoid such carcinogenicity with a smart possibility to use nano-molecules to specifically kill cancer cells. Non-thermal plasma is another modality to fight against cancer.

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Section: What Is the Major Cause Of Carcinogenesis In Humans?mentioning

confidence: 99%

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering

Toyokuni

Kong

Cheng

et al. 2020

Cancers

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“…Proliferative lesions derived from the endocrine cells of the pituitary gland, especially those in the pars distalis, are commonly encountered as spontaneous background findings in carcinogenicity studies using various rat strains including Sprague-Dawley (SD), Fischer 344 (F344), and Wistar 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 . It is known that tumors of the pars distalis are a common cause of death in aged rats, especially females 2 , 6 .…”

Section: Introductionmentioning

confidence: 99%

Histopathological and immunohistochemical features of proliferative lesions in the pituitary pars distalis of rats

Doi¹,

Kanno²,

Sato³

2021

J Toxicol Pathol

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Pituitary proliferative lesions derived from the endocrine cells of the pars distalis are frequently encountered and adenomas/carcinomas are a common cause of death in standard 2-year carcinogenicity studies using various rat strains, especially Sprague-Dawley. This report describes the immunohistochemical characteristics of pituitary tumors derived from the pars distalis in rats. Prolactin (PRL)-containing tumors are the most common, with PRL/growth hormone (GH) dual positive tumor masses (PRL/GH co-positive tumor masses) being more prevalent than only PRL-positive tumor masses (PRL single-positive tumor masses). GH-containing tumors are relatively numerous and many of these are also PRL/GH co-positive tumor masses. TSH-containing tumors are common in females. PRL-containing tumors have been shown to increase the incidence of hyperlactation in males and mammary adenomas/adenocarcinomas in females, suggesting that these masses are functional tumors.

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“…6 Elmore et al and Hojo et al reported that thymic epithelial cells in the LyR thymomas of WH rats are positive for CK18. 7,8 Additionally, Terayama et al reported that medullary thymic epithelial cells in the normal thymus of a Royal College of Surgeons rat are positive for CK14. 9 Brelińska et al reported that CK16 positive for thymic epithelial cells in the outer region of medulla of thymus in Wistar rats.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Characteristics of Thymomas and Hyperplastic Lesions in Wistar Hannover Rats

Tomonari¹,

Sato²,

Yamada³

et al. 2020

Toxicol Pathol

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Previously, we investigated the higher incidence of hyperplastic lesions and thymomas and histopathological resemblance of cortex–medullary structures between thymomas and normal thymuses in Wistar Hannover (WH) rats. Thymomas had pale-staining cell foci (PA) similar to medulla but without lymphocytes. Here, we focused on the differences in cytokeratin (CK) expression in the thymic epithelia of the cortex and medulla and compared the structures of thymomas and normal thymuses. Thymomas, hyperplastic lesions, and normal thymuses obtained from background studies of WH rats were stained with antibodies against CK14, CK18, and CD20. In normal thymuses, the epithelial cells were positive for CK14 in the medulla and subcapsular area and for CK18 in the cortex, B-cells were positive for CD20 in the medulla. In thymomas, the epithelial cells were positive for CK14 in the medullary differentiation (MD) areas and for CK18 in the cortex-like lymphocyte rich and PA, and B-cells were positive for CD20 in the MD areas.

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A histopathological analysis of spontaneous neoplastic and non-neoplastic lesions in aged male RccHan:WIST rats

Cited by 6 publications

References 19 publications

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering

Histopathological and immunohistochemical features of proliferative lesions in the pituitary pars distalis of rats

Immunohistochemical Characteristics of Thymomas and Hyperplastic Lesions in Wistar Hannover Rats

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