A histopathological and stereological study of the effects of acetylsalicylic acid on doxorubicin-induced hepatotoxicity in mice

Gökçe, Ayşe Başardı; Eren, Banu; Sağir, Dilek; Yılmaz, Burcu Demirel

doi:10.1080/10520295.2020.1788724

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Doxorubicin is also a TOP Ⅱ inhibitor and studies approved that it induces similar histopathological changes to the liver and kidney in laboratory animals through similar manner. This is by formation of semiquinone-type free radicals, and reacting with molecular oxygen to form reactive oxygen species that cause injury to plasma membranes and intracellular macromolecules (Gökçe et al, 2021;Ibrahim Fouad and Ahmed, 2021;Shivakumar et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Histopathological Studies on the Effect of Taurine Against Etoposide-Induced Acute Liver and Kidney Toxicity in Female Albino Rats

Mohammed

Alhassani

2022

UKH J SCI ENG

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Etoposide (ETP) is a topoisomerase Ⅱ (TOP Ⅱ) inhibitor and one of the leading chemotherapeutic drugs for treating a wide variety of tumors. However, ETP induced hepatotoxicity and nephrotoxicity limits its clinical use. This study aims to investigate the protective potential of taurine (Tau) to mitigated histopathological changes in the liver and kidneys of female albino rats treated with ETP. A total of 18 female rats were divided into three groups; control group, ETP-exposed group received intraperitoneal injection of ETP on the first 3 days of the study for a total cumulative dose of 44 mg/kg to induce hepatotoxicity and nephrotoxicity, ETP + Tau group received ETP as stated previously with 400 mg/kg/day of Tau via oral gavage for 15 days. Sections from the liver and kidney were evaluated under light microscope and ETP-exposed group revealed vascular congestion, chronic inflammatory cell infiltration predominantly lymphocytes, edema, vacuolar degeneration, atypical cells, pyknosis, and necrosis while liver and kidney sections of rats treated with combination of ETP + Tau group exhibited marked alleviation of the histopathological damage. The study concludes that treatment with ETP induced marked structural damages in the liver and kidney and such morphological damages are effectively diminished by administering Tau.

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Section: Discussionmentioning

confidence: 99%

Histopathological Studies on the Effect of Taurine Against Etoposide-Induced Acute Liver and Kidney Toxicity in Female Albino Rats

Mohammed

Alhassani

2022

UKH J SCI ENG

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“…In this regard, Gokçe et al, investigated the prophylactic effects of ASA against DOX in Swiss albino mice and used DOX at a dose of 10 mg/kg (single dose) as single or in combination with ASA at a daily dose of 200 mg/kg (examined after 6, 12, 24 and 48 h and 7,14 and 21 days). Their results demonstrated that, at 6 h, the portal triad areas of the DOX and DOX+ ASA groups were significantly higher than the controls and the ASA group (44). In addition, histological assessments revealed a time-dependent increase in the rate of degeneration and necrosis of liver tissues in mice in the DOX and DOX+ ASA groups.…”

Section: Acetylsalicylic Acidmentioning

confidence: 96%

None Herbal Agents as Preventive and Therapeutic Measures for Doxorubicin Induced Hepatotoxicity: A Comprehensive Review

Mahmoudi¹,

Elyasi²

2022

jpc

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Cancer is one of the most common human diseases and a leading cause of human mortality in rencent years. Doxorubicin (DOX) is an important anti-cancer agent belonging to anthracyclines drug category. This chemotherapeutic agent acts against cancer cells through different mechanisms; however, its use is related with numerous acute and chronic dose-related side effects and toxicities including hepatotoxicity. The aim of this study was to conduct a comprehensive review of in vitro, in vivo and any human studies regarding the protective effects of synthetic compounds against DOX-induced liver injury.The search was conducted in embase, PubMed and Scopus databases using the following keywords: “doxorubicin”, “Adriamycin”, “hepatotoxicity”, “liver injury”, “liver damage” and “hepatoprotective” to find experimental and preclinical studies regarding the effects of various compounds on DOX-induced hepatotoxicity. Twenty-one eligible studies to the end of May 2022 finally were reviewed (19 in vivo and 2 both in vivo and in vitro studies). Our results demonstrated that all of these drugs, except acetylsalicylic acid, had considerable hepatoprotective effects against DOX (deferoxamine had a mild effect). In addition, except glutathione, none of the studied drugs and compounds attenuated the antitumor efficacy of DOX treatment. Moreover, no human study was available in this fieild. Altogether, our results demonstrated that most of compounds with anti-apoptosis, anti-inflammatory and antioxidant properties are efficacious against DOX-induced hepatotoxicity and may have potential for being considered for inclusion in the chemotherapeutic regimes of cancer patients, after fully been assessed in well-desgined large clinical trials.

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Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar rats

Demır¹,

Altınöz²,

Koca³

et al. 2023

Tissue and Cell

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A histopathological and stereological study of the effects of acetylsalicylic acid on doxorubicin-induced hepatotoxicity in mice

Cited by 3 publications

References 21 publications

Histopathological Studies on the Effect of Taurine Against Etoposide-Induced Acute Liver and Kidney Toxicity in Female Albino Rats

Histopathological Studies on the Effect of Taurine Against Etoposide-Induced Acute Liver and Kidney Toxicity in Female Albino Rats

None Herbal Agents as Preventive and Therapeutic Measures for Doxorubicin Induced Hepatotoxicity: A Comprehensive Review

Antioxidant and anti-inflammatory potential of crocin on the doxorubicin mediated hepatotoxicity in Wistar rats

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