A Histopathological Study of Carcinoma of the Larynx

Kurita, Shigejiro; Hirano, Minoru; Matsuoka, Hidetaka; Tateishi, Morio; Sato, Kiminori

doi:10.1016/s0385-8146(85)80054-7

Cited by 16 publications

(3 citation statements)

References 5 publications

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“…9 In the histopathologic studies conducted, it has been reported that invasion of more than three quarters of the TA muscle causes fixation and in the case of invasion of three quarters or less there is movement restriction. 10 In the invasion phase leading to the fixation of the TA muscle, there is the possibility that some of the tumors staged as T1 may be of more advanced stages histopathologically. In our own case series, our detection of TA muscle (paraglottic region) invasion in 5 (31.2%) of 16 patients supports this possibility.…”

Section: Discussionmentioning

confidence: 99%

A Hystopathological Study of Thyroarytenoid Muscle Invasion in Early (T1) Glottic Carcinoma

Kocatürk¹,

Han

Yılmazer

et al. 2005

Otolaryngol.--head neck surg.

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Our finding TA muscle invasion at the rate of 31.2% in our 16 case series clinically staged as T1 revealed that deep invasion did not always impair the vocal cord mobility. Observing TA muscle invasion at the rate of 50% in cases involving the one-third anterior part of the vocal cord and the anterior commissure suggested that TA muscle invasion in the anterior part did not significantly impair mobility.

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Section: Discussionmentioning

confidence: 99%

A Hystopathological Study of Thyroarytenoid Muscle Invasion in Early (T1) Glottic Carcinoma

Kocatürk¹,

Han

Yılmazer

et al. 2005

Otolaryngol.--head neck surg.

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“…In the study by Olofsson, other features of subglottic tumors were extensive circumferential growth and cartilage invasion. A high rate of cartilage invasion was also demonstrated by Kurita et al, who conducted a histopathological study of 51 serially sectioned laryngectomy specimens. The incidence of cartilage invasion was highest in subglottic carcinomas; thyroid cartilage invasion was present in 67% and cricoid cartilage invasion was present in 33%.…”

Section: Anatomy Of the Subglottic Larynx And Pathways Of Tumor Spreadmentioning

confidence: 59%

Prognosis of subglottic carcinoma: Is it really worse?

et al. 2018

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It is traditionally accepted that subglottic carcinoma has a worse prognosis than tumors arising in other subsites of the larynx, owing to its tendency to present in advanced stages, with a high incidence of cartilage invasion and extralaryngeal spread. The incidence of subglottic carcinoma varies among series, mainly because there is no uniform definition of the upper boundary of the subglottis. The extent of the tumor may be difficult to define because subglottic carcinoma may spread through the submucosa without visible mucosal changes. There is also a rich lymphatic network in the subglottis draining to the prelaryngeal and paratracheal lymph nodes, which are usually not involved by cancers arising in other laryngeal subsites. Current literature data indicates that early-stage subglottic carcinoma can be treated using radiotherapy or chemoradiotherapy with high locoregional control and survival rates. In advanced stage subglottic carcinoma, combination of surgery followed by radiotherapy or chemoradiotherapy resulted in comparable outcomes, as in advanced carcinomas from the rest of the larynx. Stage for stage, it is likely that the prognosis for subglottic carcinoma and of glottic and supraglottic cancers is similar.

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“…Impaired vocal fold movement and VFF in glottic laryngeal carcinoma were defined as a carcinomatous invasion of less or more than 3-quarters of the thyroarytenoid muscle. 19 Several studies have described the association between tumor response or prognostic role and remobilized vocal fold or persistent VFF after non-surgical treatment completion. 10,[20][21][22] Solares et al 20 reported that remobilization of VFF was observed in 7/12 patients with glottic carcinoma at CRT completion.…”

Section: Discussionmentioning

confidence: 99%

Comparative Treatment Outcome in T3N0 Glottic Cancer With and Without Vocal Fold Fixation Receiving Radiation Therapy and Concurrent Low-Dose Intra-Arterial Cisplatin Infusion

Ono

Tanaka

Chitose

et al. 2021

Ann Otol Rhinol Laryngol

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Objectives: Selective radiotherapy and concomitant intra-arterial cisplatin infusion (m-RADPLAT) with a lower cisplatin dosage have been performed for organ and function preservation in patients with locally advanced squamous cell carcinoma of the larynx (SCC-L), and results showing a lower rate of adverse events have been reported. This study evaluated the treatment outcomes of patients with T3N0 glottic SCC-L with or without vocal fold fixation (VFF) who were treated with m-RADPLAT. Methods: We retrospectively reviewed the data of 33 patients with T3N0 SCC-L who received m-RADPLAT. Results: The vocal fold in patients with VFF 3 months after completing m-RADPLAT resumed normal movement in 15 patients (83%) and persisted fixation in 3 (17%). The 3-year local control, laryngeal cancer-specific survival, and overall survival rates of patients with or without VFF were 88.9% and 86.7%, 94.1% and 93.3%, and 88.9% and 86.7%, respectively. Additionally, the 3-year freedom from laryngectomy, laryngectomy-free survival, and laryngo-esophageal dysfunction-free survival rates of patients with or without VFF were 94.4% and 86.7%, 88.9% and 73.3%, and 83.3% and 73.3%, respectively. Grade 3 or higher toxicities were observed in all patients: leukopenia in 4 patients (12%), neutropenia in 5 (15%), anemia in 2 (6%), thrombocytopenia in 3 (9%), and mucositis in 2 (6%). Conclusions: This study demonstrated that m-RADPLAT yielded VFF improvement and a favorable survival while maintaining laryngeal function not only in patients with T3N0 glottic SCC-L without VFF but also in patients with VFF.

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A Histopathological Study of Carcinoma of the Larynx

Cited by 16 publications

References 5 publications

A Hystopathological Study of Thyroarytenoid Muscle Invasion in Early (T1) Glottic Carcinoma

A Hystopathological Study of Thyroarytenoid Muscle Invasion in Early (T1) Glottic Carcinoma

Prognosis of subglottic carcinoma: Is it really worse?

Comparative Treatment Outcome in T3N0 Glottic Cancer With and Without Vocal Fold Fixation Receiving Radiation Therapy and Concurrent Low-Dose Intra-Arterial Cisplatin Infusion

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