A Histopathological Study of Endometrium in Infertility

Murmu, Silbina; Baitha, Budhan; Singh, Dr.U.S.

doi:10.9790/0853-1601115660

Cited by 3 publications

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“…In the present study, a luteal phase defect was noted in 3 of the 75 cases (4%) studied. This is similar to that noted by Murmuet al 6 who reported luteal phase defect in 8.2 % of the 79 cases studied. This is the present study accounted for 1 of the 58 (3.5 %) cases with primary infertility and 2 of the 17 (5.8%) cases with secondary infertility.…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, endometrial hyperplasia accounted for 4% of the 75 cases. This is similar to the observations of Murmu et al 6 (2.74%), Sabharwal et al 12 (2.66%), Shastrabudhe et al 13 (4.4%), and Sharma et al 14 (6.0%). Ahmed et al 10 from Bangladesh who found a slightly higher incidence of 10.7%, analyzed data from various countries and found this feature to be lower in India compared to Pakistan and Nigeria where incidence was as high as 14% and 20% respectively.…”

Section: Discussionsupporting

confidence: 91%

“…In a rural hospital setup, where immunological and hormonal assay procedures are not easily available or affordable, endometrial biopsy is an important investigation for infertility. 6 In our study, primary infertility was more common than secondary infertility i.e. 58 cases out of 75 cases (77.3%) studied.…”

Section: Discussionmentioning

confidence: 51%

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A study on glycogen content of endometrial glands in infertile women

Shetageri

2021

J Pathol Nep

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Background: Infertility is a public health problem worldwide. One of the important factors involved in infertility is the poor quality of endometrium which leads to death of the ovum before and after implantation. Glycogen is known to be a direct source of nutrients for the early conceptus and its depletion may result in inadequate preparation of endometrium around the time of implantation and leading to infertility. Materials and methods: This is a prospective study conducted at a tertiary care hospital for 2 years. The study included 75 cases of infertility (primary and secondary). Relevant data were collected from all the 75 biopsied infertile cases during the study period. Periodic acid Schiff stain was performed on all cases to detect the amount of glycogen in the endometrium. The findings were compiled, analyzed, and compared with other studies. Results: Primary infertility accounted for 77.3%and Secondary infertility 22.7% of the 75 cases. On histology, anovulatory cycles accounted for 52% of cases. In the remaining cases, 38.7% showed secretory phase, 4%cases each showed luteal phase defect and hyperplasia, and 1.3% tubercular endometritis. Glycogen content of the endometrium was (1+) in 54.6%, (2+) in 9.3%, (3+) in 9.3% and (4+) in 26.8% in the infertility patients.Glycopenia was seen in 12% of the 75 cases studied. Conclusions: Endometrial factors are important causes of infertility and depletion of glycogen, that can be corrected by hormonal therapy to improve the fertility potential needs to be evaluated in all cases of infertility.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

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A study on glycogen content of endometrial glands in infertile women

Shetageri

2021

J Pathol Nep

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“…Most common age group of infertility was from 21 years to 30 years which correlated with the studies done by 10,11,13,14,16,17 Secretory phase endometrium means that the women is ovulating and there are good chances of conception in subsequent cycles. However, inspite of ovulatory endometrium defect may be present somewhere else, it can be due to luteal phase defect and depletion of glycogen that results in inadequate preparation of endometrium at the time of implantation and henceforth leading to infertility.…”

Section: Age Distributionsupporting

confidence: 54%

Glycopenic endometrium in infertility

2022

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Background: Infertility is a global health problem affecting 8-10% couples worldwide. Endometrium is considered to be sensitive indicator of ovarian, pituitary and hypothalamic function. The endometrium, which fails to produce adequate amount of glycogen is termed as ‘glycopenic uteri’. Glycopenic endometrium is said to be unfavourable for early blastocyst implantation leading to infertility in spite of ovulation. Endometrial aspiration/biopsy can be histologically dated based on the Dallenbach-Hellweg criteria which forms an essential part of histopathological examination of endometrium for infertility work-up. The aim of the study was to study the correlation of glycogen content with endometrial histomorphology in infertility.Methods: Cross-sectional observational study in which one hundred twenty-two endometrial specimens sent as curetting/ biopsy were studied. The Glycogen content of endometrium was graded from + to ++++ as given by Arzac and Blanchet. Statistical analysis was done on SPSS version 26.0. The categorical variables were represented by count (percentage) and the continuous variables were represented by mean±SD. The Chi-square test was used to find the association of glycogen content with infertility, the various phases of the endometrium and age.Results: Glycopenic endometrium was seen in 36.9% cases of infertility. Out of which, glycopenic endometrium was much more prevalent in patients with secondary infertility (47%) as compared to patients with primary infertility (35.1%). Conclusions: Glycogen depletion in secretory phase results in inadequate preparation of endometrium at the time of implantation. Assessment of glycogen is considered to be an essential part of histopathological examination.

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Histomorphological Study of Endometrium in Primary Infertility in Rural Setup

Agrawal,

Hiwale,

Bhake

2021

Journal of Datta Meghe Institute of Medical Sciences University

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Background: In our society, females are blamed for infertility. Females especially in rural places face many problems socially and emotionally. Infertility is an obstacle in the development of couple when it does not take place normally. Infertility is a curse for women, the cause of which should be diagnosed accurately and early. Taking the abovemaintained silent plight of infertile females, this study was conducted based on uterine infertility as a step to increase understanding of pathological causes of primary infertility and serve community on the whole. Aim: This study aims to study histomorphological features of endometrium in primary infertility to know the etiological factors in a rural setup. Objectives: (1) To find various histomorphological patterns of endometrium in primary infertility. (2) To categorize the various etiologic causes under the following heads: (i) Hormonal cause. (ii) Infectious cause. (3) To find the principle cause for primary infertility in the ruler setup. (4) To know the importance of endometrial biopsy/dilatation and curettage (D and C) in primary infertility. Materials and Methods: A total of 99 endometrial sample of primary infertility were received from Department of Obstetrics and Gynecology of confirmed case of primary infertility. The endometrial biopsy or D and C were send in 10% formalin to department of pathology. The samples were processed, stained with hematoxylin and eosin and were studied and categorized into normal proliferative phase, inadequate proliferative phase, anovulatory phase, normal secretory phase, inadequate secretory phase/luteal phase defect (LPD), glandulostromal disparity (GSD), acute endometritis, chronic nonspecific endometritis, and tubercular endometritis. Observation and Results: It was observed that 42.42% patients had normal secretory phase or normal proliferative phase, i.e., it correlates with day of menses. The most common etiological cause for primary infertility was anovulation which was 28.28%. The second most common was LPD/inadequate secretory phase which was 15.15%. Inadequate proliferative phase was 8.08%. GSD was 3.03%. Endometrial hyperplasia was 4.04% among which 3.03% patients had simple hyperplasia without atypia and 1.01% patient had atypical complex hyperplasia. In infections, tubercular endometritis was 2.02% and chronic nonspecific endometritis was 1.01%. In the present study, anovulation was the principle cause of female primary infertility. There were 51.51% patients of primary infertility with hormonal cause and 3.03% patient with infective cause. Conclusion: Anovulation was the principle cause of female primary infertility and LPD was the second common cause of female primary infertility. In infections, tubercular endometritis was common whereas chronic nonspecific endometritis was less. Endometrial biopsy/D and C is a standard tool to know causes of primary infertility, which gives information at cellular level and detects hormonal causes, infective causes for infertility. Thus, by endometrial biopsy/D and C, we come to know the probable cause of female primary infertility, and accordingly, the treatment can be given to patient.

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A Histopathological Study of Endometrium in Infertility

Abstract: Abstract:Infertility is defined as inability of couple to achieve conception after one year of unprotected coitus.

Cited by 3 publications

References 1 publication

A study on glycogen content of endometrial glands in infertile women

A study on glycogen content of endometrial glands in infertile women

Glycopenic endometrium in infertility

Histomorphological Study of Endometrium in Primary Infertility in Rural Setup

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